Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"HME"”.
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Hot melt extrusion (HME) processing for the development of lipid oral solid dosage forms
… the use of lipids in hot melt extrusion (HME) for the preparation of sustained release solid lipid matrices. The use of lipids instead of polymers is a novel approach with distinct advantageous. Sustained release solid lipid matrices of diclofenac sodium (Df-Na)/Compritol® 888 ATO (888 …
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Development and Characterization of Sustained-Release Formulations via Novel Hot Melt Extrusion Techniques
Hot melt extrusion (HME) is a leading technology that can be applied to many pharmaceutical preparations as solid dispersions. Part of this research project focus on injecting pressurized carbon dioxide (P-CO2) gas during the HME process. These combined techniques have an additional advantage of …
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The development of PVP-based solid dispersions using hot melt extrusion for the preparation of immediate release formulations
… the use of solid dispersion. Hot melt extrusion (HME) method was introduced in formulating solid dispersion. The use of this production method offers many advantages such as environmental friendly, cost sparing and readily scalable production as compared to conventional methods. On the other hand, …
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Dissolution kinetics of model api in molten polymer excipients during batch processing
… application field, hot-melt extrusion (HME) has been recently introduced to develop new solid dosage forms and products. By dissolving the poorly-soluble active pharmaceutical ingredients (API) into water-soluble polymers, the bioavailability of the Class II (with low solubility and high …
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Untersuchung verschiedener Atemgasklimatisierungssysteme unter Hochfrequenzoszillationsbeatmung
… so genannte Wärme-und Feuchteaustauscher (HME) unter HFOV in einem hierfür entwickelten Lungenmodell.Methode:Die Untersuchungen wurden mit einem in der Pädiatrie eingesetzten HFOV durchgeführt. Das Lungenmodell enthielt einen Wasserbehälter um Evaporation zu simulieren und wurde in einen …
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Influence of hot melt extrusion processing parameters on the properties of a pharmaceutical formulation
Hot melt extrusion (HME) is an old technology that has been recently adapted to be used in the pharmaceutical industry. HME is a continuous process that is widely used to produce a solid dispersion matrix. The aim of this dissertation is to evaluate different factors that will affect the …
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Solubility enhancement, mechanical properties and taste masking of poorly water soluble compounds by optimizing hot melt extrusion processing
… project studies the use of hot melt extrusion (HME), together with hydrophilic polymers, to improve availability of poorly soluble compounds. In recent years HME has become widely accepted as a viable drug delivery system. HME is useful for several different purposes, including solid-state …
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Design of a fast cycle time hot micro-embossing machine
… of these techniques is Hot Micro-Embossing (HME). In this process, a thermoplastic polymer workpiece is heated above its glass transition temperature and a micro-patterned die is forced into it. The polymer conforms to the workpiece and the features are replicated. Much of the research to …
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Solvent Free Technologies for Polymer based Crystal Engineering and Drug Delivery
… has been also explored for the advantages over HME process in terms of residence time, plasticiser free dispersions, effect of process on degradation of drugs during processing. For this purpose, the process and material modifications during operation of these two technologies was important …
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Characterization of different hydrophilic polymers and their applicability in hot melt extrusion technology
… a novel technology such as hot melt extrusion (HME) in combination with hydrophilic polymers to obtain tailored drug release. Over recent years HME technology has found widespread application as a viable drug delivery option in the drug development process. Some of the HME applications include …
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Implementing process analytical technology (PAT) tools for the analysis and control of manufacturing processes during hot-melt extrusion
… reported in this thesis, hot-melt extrusion (HME) was coupled with process analytical technology (PAT) tools in order to investigate drug interactions during processing, identify drug/excipient interactions and monitor the quality of the extruded products. In order to ensure the quality of the …
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Design of a micro-Functional Testing System for process characterization of a hot micro-embossing machine
… set of processes such as hot micro-embossing (HME) have received increased attention as manufacturing processes for high-volume polymer-based micro-fluidic production. An understanding of the equipment, process physics, control strategy, and metrology for part fabrication are required when …
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Hot-melt mixing of partially miscible active pharmaceutical ingredient-polymer mixtures
… oral dosages such as hot-met extrusion (HME) have received increasing attention by industry and academe because they can enhance drugs' solubility and even bioavailability to a great extent by converting drugs from crystalline to amorphous form. HME can be carried out at two process …
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Assessment of a marine polysaccharide for use as excipient in pharmaceutical hot-melt extrusion
Pharmaceutical Hot Melt Extrusion (HME) is currently investigated by both industry and academia as a method for manufacturing solid oral dosages with improved bioavailability of poorly-water soluble active pharmaceutical ingredients (APIs) and control drug release of water-soluble APIs. Although …
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Dispersion and dissolution kinetics of API particles in pharmaceutical hot melt extrusion
Pharmaceutical Hot Melt Extrusion (HME) is essentially a special case of polymer compounding. The elementary steps involved in traditional plastics melt processing are handling of particulates, melting, dispersive and distributive mixing, devolatilization and stripping, and finally pressurization …
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Development of cocrystals of water insoluble active substances with inactive excipients by using hot melt extrusion
… was to develop and optimise hot melt extrusion (HME) as a robust technique for the cocrystallisation of poorly water soluble drugs and their coformers. Two pairs of cocrystals of a poorly water soluble drug, carbamazepine, with saccharin and trans-cinnamic acid, were produced by using single …
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Nuclear Magnetic Resonance for the Characterisation of Hot-Melt Extruded Pharmaceutical Amorphous Solid Dispersions
… of poorly soluble APIs. Hot-melt extrusion (HME) is one method for preparing ASDs that is growing in importance in the pharmaceutical industry. HME involves the combination of an API and a polymer, which are heated and intensively mixed to yield a homogeneous product. Despite the growth in …
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Design and development of drug delivery systems for immediate and sustained release utilizing hot melt extrusion
… profile during formulation development for HME (Hot melt extrusion). Many commercially available, pharmaceutical-grade polymers can be used in HME formulations. The suitable polymer choice facilitates processing in the extruder. When choosing a polymer to use in a formulation, processing …
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Batch foaming of hot melt extruded excipient/disintegrant/API pharmaceutical formulations and the study of the effects of the resulting cellular structures on API dissolution
… part of this research, the Hot Melt Extrusion (HME) process is used to compound the following pharmaceutical formulations: EPO/AcDiSol/INM and EPO/Cros/INM containing different percentages of disintegrant. Comprehensive characterization of this system carried out by Hot-stage Polarized Optical …
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