Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"HMC"”.
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Co-generation with GANs using AIS based HMC
Inferring the most likely configuration for a subset of variables of a joint distribution given the remaining ones – which we refer to as co-generation – is an important challenge that is computationally demanding for all but the simplest settings. This task has received a considerable amount of …
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Regulation Mechanisms of TIM-3 expression in Jurkat T cells and HMC-1 cells
… 사용한 결과 Jurkat T 세포와 인간 CD4+ T 세포에서는 MEK 경로, HMC-1 세포에서는 MEK 경로와 SMAD 의존적 경로가 TIM-3 발현에 중요하게 작용함을 밝혔다. 또한 T 세포에서 TIM-3 발현 조절에 중요하게 작용하는 promoter 부분을 찾기 위해 다양한 길이의 TIM-3 promoter를 포함하는 luciferase reporter vector를 제작하여 luciferase 활성도를 측정하였다. 그 결과 TIM-3 promoter -892/-870과 -144/-121 부분이 자극에 의한 …
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Effects of IL-33 on the interaction between HMC-1 cells and human airway smooth muscle cells
… on the above processes were also investigated. HMC-1 cells were analysed for the presence of several adhesion molecules, using a primary and secondary antibody, which were quantified using a fluorescently activated cell sorting machine (FACS). Once the presence of the adhesion molecules were …
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Functional analysis of 5-hydroxymethylcytosine
… modified cytosine, 5-hydroxymhetylcytosine (5-hmC), was identified and found at significant levels in mouse brain and both mouse and human embryonic stem (ES) cells. The conversion of 5-mC to 5-hmC is catalyzed by the ten-eleven translocation (TET) proteins of the 2-oxoglutarate (2OG)-and …
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General and Efficient Bayesian Computation through Hamiltonian Monte Carlo Extensions
<p>Hamiltonian Monte Carlo (HMC) is a state-of-the-art sampling algorithm for Bayesian computation. Popular probabilistic programming languages Stan and PyMC rely on HMC’s generality and efficiency to provide automatic Bayesian inference platforms for practitioners. Despite its wide-spread use and …
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The HLA Complex Group 9 Gene Modification Study in Major Psychosis
… (5-mC) and 5-hydroxymethylcytosine (5-hmC) in neural and non-neural tissue from mice and humans. 5-hmC has been recently found to be abundant in brain but its function is poorly understood. We assayed 5-hmC by using glucosylation coupled with restriction enzyme digestion and microarray …
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Advanced Sampling Methods for Solving Large-Scale Inverse Problems
… is based on a Hybrid/Hamiltonian Monte Carlo (HMC) approach that can handle non-normal probability distributions. The first algorithm proposed in this work is the "HMC sampling filter", an ensemble-based data assimilation algorithm for solving the sequential filtering problem. Unlike …
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Epigenetic regulation by 5-hydroxymethylcytosine in atopic dermatitis and psoriasis and its implications for epidermal stem cell behavior
… pathway, 5- hydroxymethylcytosine (5-hmC) is an epigenetic marker that significantly influences gene expression, with major consequences for embryonic development, stem cell identity, and ultimately organ homeostasis. Keratinocyte stem cells (KSC) maintain a healthy skin barrier by …
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Alterations in Genomic 5-Hydroxymethylcytosine Level in Hepatocellular Cancer
… to initiate HCC. 5-hydroxymethylcytosine (5-hmC), recently identified sixth base of the genome, can cause demethylation by its conversion to cytosine through reactions catalyzed by the TET enzymes. Research on the role of this novel modification in the liver and HCC is needed before it can be …
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Regulation of TIM-3 Expression in Mast cells and Monocytes
… TIM-3 and galectin-9 in a human mast cell line, HMC-1 cells. TIM-3 transcription in HMC-1 cell was upregulated only by TGF-b but not by IFN-a, IFN-l, TNF-a, IL-10, LPS or FcεR cross-linking. Whereas transcription of TIM-3 ligand, galectin-9 was not affected by treatment with TGF-b. To reveal …
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Integral geometry, Hamiltonian dynamics, and Markov Chain Monte Carlo
… introducing a bias. Hamiltonian Monte Carlo (HMC) algorithms are some the most widely-used MCMC algorithms. We use the symplectic properties of Hamiltonians to prove global Cheeger-type lower bounds for the mixing times of HMC algorithms, including Riemannian Manifold HMC as well as No-U-Turn …
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Epigenetic and Ubiquitin-Proteasome Mechanisms of Obesity Development
… phenotype. Further, DNA 5-hydroxymethylation (5-hmC) is one type of DNA methylation that is 10 times more abundant in the brain than peripheral tissues. However, to date, no study has been conducted examining whether DNA 5-hmC becomes altered in the brain following weight gain and/or contributes …
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Purification of uridine diphosphate glucuronyltransferase
… (PNP) and 7-hydroxy-4-methylcoumarin (HMC). For this last substrate, HMC, a new continuous fluorometric assay was developed. The purification fold and activity recovery, respectively, towards each substrate was as follows: bilirubin, 31 and 80%; PNP, 31 and 80%; and HMC, 24 and 60%. The …
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A Comparison of Bayesian Estimation Techniques in a Multidimensional Two-Parameter Partial Credit Item Response Model
… and Hamiltonian Monte Carlo-No-U-Turn-Sampler (HMC-NUTS) for M2PPC models' parameter estimation. It compared the estimation accuracy and computing speed in different combinations of situations, including prior choices, test lengths, and the relationships between dimensions.</p> <p>The datasets …
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A Study in Hybrid Monte Carlo Methods in Computing Derivative Prices
Hybrid Monte Carlo (HMC) method is defined in this thesis as Monte Carlo method that utilizes conditional expectation so that the regular Monte Carlo method and other computational methods can be combined to price financial derivatives. This thesis introduces several hybrid Monte Carlo methods and …
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Numerical studies of the critical behaviour of non-commutative field theories
… SU(2) geometry by using Hybrid Monte Carlo (HMC) techniques. The first system under study is a matrix regularization of the φ4 theory defined on the sphere. We develop a HMC algorithm together with an SU(2) gauge-fixing procedure in order to study the model. We extract the phase diagram of …
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Covalent DNA Modifications in Phage and Bacterial Dynamics
… to glycosylated hydroxymethylcytosine (glc-HMC), and the two mutant T4 phage contain either hydroxymethylcytosine (HMC) or unmodified cystosines (C). These tests confirmed that glc-HMC and HMC in high concentrations can block CRISPR-Cas9. 3) To explore interactions between bacteria and phage …
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Nucleobase, Nucleoside, And Neighboring Nucleotides: Intrinsic Preferences For Tet Enzyme-Mediated Oxidation Of 5-Methylcytosine
… (mC) sequentially, to 5-hydroxymethylcytosine (hmC), 5-formylcytosine (fC), and 5-carboxycytosine (caC). The biochemical preference of TET enzymes for these substrates, in the canonical cytosine guanine dinucleotides (CpG), mimics the order in which they are generated and is reflected in levels …
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Effetti dell'acido urico sulle cellule glomerulari mesangiali: meccanismi intracellulari di trasduzione del segnale e possibili implicazioni nella progressione del danno renale e nella sindrome infiammatoria in corso di nefropatie croniche
… evaluated the cellular effects of UA on cultured HMC as a potential interstitial target for abnormally elevated levels in acute and chronic renal disease. Intracellular free Ca2+ ([Ca2+]i) was monitored by microfluorometry of fura 2-loaded cells, while oxidation of intracellularly trapped …
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Characterization of Broiler Lines Divergently Selected for Breast Muscle Color
… (L*). After 10 generations of selection, the HMC and LMC lines (selected for high and low L* respectively) as well as a random bred control base population (RBC) were characterized through several studies. Experiment 1 characterized the pH decline of the lines under two different chill …
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