Global ETD Search
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Showing 1 to 6 of 6 for “"HLHS"”.
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Structural variant calling by assembly in whole human genomes: Applications in hypoplastic left heart syndrome
… discovery in Hypoplastic Left Heart Syndrome (HLHS). This method circumvents many of the limitations of variants called from a reference alignment: unmapped reads will be included in a sample’s assembly, and variants up to thousands of nucleotides can be detected, with the full sample variant …
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Multi-Scale Fluid Flow Analysis of the Cardiovascular System
<p>The hypoplastic left heart syndrome (HLHS) is one of the rarest congenital heart diseases affecting infants. Out of 150 babies born, one baby suffers from congenital heart disease. Furthermore, nine percent out of those suffering from congenital heart disease specifically suffer from hypoplastic …
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CELF1, PTBP1, and RBFOX2-mediated alternative splicing regulation in cardiovascular diseases
… (T1D) and hypoplastic left heart syndrome (HLHS) patient hearts but the mechanisms responsible are unclear. Here, we provide evidence that in these patient’s hearts that dysregulation of the RNA binding proteins (RBPs) CELF1, PTBP1, and RBFOX2 contribute to AS changes. Utilizing genome-wide …
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Effects of GATA4-targeted compounds in hypertrophic models of hypoplastic left heart syndrome cardiomyocytes
… sydänpuoliskon vajaakehittyneisyysoireyhtymä (HLHS) edustaa harvinaista mutta hengenvaarallista alatyyppiä. HLHS:lle on ominaista sydämen vasemmanpuoleisten rakenteiden alkeellinen kehitys, mikä johtaa sydämessä merkittävään verenvirtauksen estoon, heikentäen systeemistä verenkiertoa. Nykyinen …
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Evaluation of Recurrence Risks For Left-Sided Cardiac Lesions
… accepted that hypoplastic left heart syndrome (HLHS), aortic valve stenosis with or without bicuspid aortic valve (AS/BAV) and coarctation of the aorta (CoA) occur in families more commonly with each other than with any other congenital heart defect (CHD). Genetic counseling for CHDs is …
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A Coupled CFD-Lumped Parameter Model of the Human Circulation: Elucidating the Hemodynamics of the Hybrid Norwood Palliative Treatment and Effects of the Reverse Blalock-Taussic Shunt Placement and Diameter
… neonates with Hypoplastic Left Heart Syndrome (HLHS), in which a sustainable univentricular circulation is established in a less invasive manner than with the standard procedure. A computational multiscale model of such HLHS circulation following the HN procedure was used to obtain detailed …