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Showing 1 to 2 of 2 for “"HLH transcription factors"”.
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Structural characterization and biochemical analysis of ID2, an inhibitor of DNA binding
The ID proteins, a class of transcription regulators, were named for their role as inhibitors of DNA-binding and differentiation. They contained a helix-loop-helix (HLH) domain without a basic DNA-binding domain and functioned through dimerization with basic-HLH transcription factors to inactivate …
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DNA Recognition by Helix-Loop-Helix Proteins
<p>The Helix-Loop-Helix (HLH) family of eukaryotic transcription factors comprises a large number of proteins which play key roles in homeostasis, the regulation cell proliferation, and differentiation. These proteins share a phylogenetically conserved bipartite b/HLH domain responsible for …