Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"HLA-I"”.
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Tapasin - The star of the show in HLA-I maturation
Human leukocyte antigen class I (HLA-I) molecules are present on the cell surface of all nucleated cells. They bind intracellular peptides and present them to the immune system thus providing a readout to cytotoxic T-cells about the status of a cell. Maturation of the HLA-I molecule includes …
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Selbsttoleranz von NK-Zellen
… NK-Zellen detektiert, welche keinen bekannten HLA-spezifischen inhibitorischen Rezeptor exprimieren. Diese Entdeckungen widersprechen dem bisher gültigen at-least-one -Modell, nach dem die Selbsttoleranz durch mindestens einen inhibitorischen Rezeptor gewährleistet würde. In dieser Dissertation …
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The role of soluble factors affecting the major histocompatibility complex class I molecules In an IN VITRO model of the fetomaternal interface
… on the cell surface as human leukocyte antigen (HLA). HLA-G is one of the members of HLA-Ib and, together with HLA-E and HLA-F, is thought to play a key role in maternal tolerance to the semi-allogenic embryo, one haplotype comes from the mother, and is shared with her, while the other comes from …
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Conserved Non-Pocket Interactions Drive The Diversity of Peptide Presentation By Mhc Class I Molecules
… peptides presented on human leukocyte antigen (HLA) molecules. A thorough understanding of peptide-HLA interactions is needed for improvement of CTL-based immunotherapies. We observed that aspartic acid (D) and glutamic acid (E) at peptide position 4 are highly prevalent in HLA-I peptide …
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Resident angiogenic mesenchymal stem cells from multiorgan donor thoracic aortas
… cells was found. These cells expressed intensely HLA-I antigens both before and after cryopreservation and after 4 days of organ cultures remained viable. Following these preliminary results, we succeeded to isolate mesenchymal cells from multi-organ thoracic aortas using a mechanical and …
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Expression und immunmodulatorische Funktion von HLA-G und seinen verkürzten Isoformen in Tumorzellinien
Das nicht polymorphe HLA-Klasse-I-Antigen HLA-G wird hauptsächlich in der Plazenta exprimiert, wo es vermutlich den semiallogenen Fötus vor Angriff des mütterlichen Immunsystems schützt. Eine Besonderheit von HLA-G ist das Auftreten von mehreren verkürzten Isoformen, die von alternativ gespleißten …