Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"HLA-DQB1"”.
-
The genetic background of gestational diabetes mellitus
… Prediction in Skåne) study we typed for HLA-DQB1 alleled, the transcription factor 7-like 2(TCF7L2) rs7903146, rs12255372 and rs7901695 SNPs, the 1858 C>T SNP of the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene and we tested for the presence of islet cell autoantibodies …
-
Exploring the Grey Zone between Type 1 and Type 2 Diabetes
… presence of certain risk genotypes such as HLA-DQB1, INS VNTR, PTPN22 and need of insulin for survival. In adults the same situation is often referred to as Latent Autoimmune Diabetes in Adults (LADA), with age at onset after 35 years and non-insulin requiring at least for 6 month after …
-
Candidate Genes for Late Diabetic Complications
… The association was complex and dependent on the HLA-DQB1 genotypes, with partly different alleles conferring susceptibility in type 1 and type 2 diabetic patients. We cannot exclude that these genes are a part of a large haplotype block that also includes HLA-DQB1 risk genotypes. Although this …
-
Strategien zur HLA-Typisierung mit PyrosequencingTM
… Region im humanen Genom. Die Untersuchung von HLA-Genorten stellt ein wichtiges Instrument in der molekulargenetischen Praxis dar. Die Pyrosequencing-Technik ist gut geeignet, um kurze DNA-Abschnitte mit weitgehend bekannter Sequenz schnell und effizient zu untersuchen. Ziel dieser Arbeit war …
-
Epigenetická regulace genů HLA II. třídy a jejich role u autoimunitních onemocnění.
… genetické riziko T1D je spojováno s geny HLA (lidské leukocytární antigeny) II. třídy. HLA II. třídy hrají klíčovou úlohu při regulaci imunitní odpovědi. Podílejí se na selekci T buněčného repertoáru v thymu a na prezentaci antigenních peptidů CD4+ T lymfocytům. Exprese genů HLA II. třídy …
-
Occurrence, determinants and dynamics of HPV coinfections in a cohort of Montreal university students
… new), though some genes of the immune response (HLA-DQB1*06:02, HLA-G*01:01:03 and HLA-G*01:01:05) were also significant predictors. Women with coinfections, particularly those with 4+ HPV types, also had longer infection durations and greatly increased odds of SIL. Conclusions: Women with …
-
Methods Development in Inflammatory Bowel Disease
… genes of interest. Three of the genes, TNFSF8, HLA-DQB1, and CHRNA4, were shown to increase risk of disease and two of the genes, ADCY7 and LSAMP, were found to be protective. In this study, I have identified novel genes and pathways for further IBD research. These methods have the potential to …
-
Genetic and immunological risk factors of gestational diabetes mellitus
… found to share some genetic features such as HLA DQB1 risk genotypes (odds ratio [OR] 1.36, [95% CI 1.03?1.79], p=0.03) with type 1 diabetes. Furthermore, Arabian women with GDM were more insulin resistant than Scandinavian women with GDM and with the same BMI. We also investigated whether GDM …
-
Study of patients with selective immunoglobulin A deficiency: clinical phenotype and immunological evaluation
… κλινικών δεδομένων και λεπτομερούς ανάλυσης των HLA αντιγόνων. Η μελέτη περιλάμβανε δύο συνιστώσες: (1) αναδρομική κλινική κοορτή παιδιατρικών και ενήλικων ασθενών με SIgAD, με αξιολόγηση του φαινότυπου κατά τη διάγνωση και κατά τη μακροχρόνια παρακολούθηση, και (2) ανοσογενετική ανάλυση τύπου …
-
Searching for Celiac Disease Screening-detected celiac disease in an HLA-genotyped birth cohort
… mediated enteropathy strongly associated with HLA-DQB1*02 (DQ2), *0302 (DQ8), or both and the presence of tissue transglutaminase autoantibodies (tTGA). Prevalence studies have revealed that most affected individuals go undetected because of subclinical signs or being asymptomatic rendering …
-
Biochemical and Immunological Mechanisms Underlying Differential Interaction of Superantigens with Host Immunogenetic Factors in Streptococcal Sepsis
… (Strep SAgs). SAgs interact simultaneously with HLA class II molecules on antigen presenting cells (APC) and with the T cell receptor beta chain variable elements (TCR V) and cause excessive stimulation of both cell types and massive release of inflammatory mediators. </p> <p>The Strep SAgs …
-
Characterizing various aspects of the male genital tract barrier function and immunity
… To describe the prevalence of aSTIs, including Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis and Mycoplasma genitalium at two medical circumcision clinics in the Western Cape, South Africa. 2. To characterize in vivo and ex vivo penile barrier function, represented by …