Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"HLA Class I"”.
-
Investigating the role of HLA class I derived peptide in alloreactivity.
… peptide complexed with human leukocyte antigen (HLA) can be said to have a significant role in the generation of alloresponses, both in terms of cellular and humoral alloresponses. Previous researchers have identified minor histocompatibility antigen (mHAG) derived peptides such as HA-1, and …
-
Characterising the immunopeptidome in hepatitis B
… HBV-derived peptides on major histocompatibility class I (MHC-class I, human leukocyte antigen (HLA) class I in humans) molecules on the cell surface is crucial to mount antiviral immune cell mediated responses. Immunogenic peptides are generated and selected via the HLA class I antigen …
-
Human macrophage model for selective evaluation of CD8⁺ and γδ⁺ cytotoxic T cell function in tuberculosis
… and present mycobacterial antigens to human HLA class I-matched cytotoxic T lymphocytes (CTLs). Differentiation of U937 cells usmg IFN-γ, 1,25-(OH)₂ vitamin D₃, or PMA significantly enhanced their ability to phagocytose M. tuberculosis but failed to induce a subsequent respiratory burst …
-
Intrinsic genetic resistance of lymphocytes to influenza virus infection
… suggested that homozygous expression of HLA class I alleles may be associated with protection of lymphocytes against infection by influenza virus. There was absence of viral transcription in the lymphocytes of HLA-A homozygous subjects, although all monocytes were infected.\r\nMy specific …
-
The significance of antibody production in human renal transplantation
Screening for HLA specific antibodies is an important part of laboratory testing for transplantation. The conventional technique for screening is complement dependent lymphocytotoxicity. The development and increasing use of the sensitive flow cytometric crossmatch technique has meant that this …
-
Senescence and the Innate Immune System
… be enhanced removal of senescent cells. The non-classical human leukocyte antigen class I molecules E, F and G (HLA-E, -F and -G), are ligands for NK cells and considered tolerogenic. For example, HLA-E binds with the NK inhibitory receptors, killer cell lectin like receptor D1 (CD94) and c-type …
-
Characterisation of antibody populations in renal dialysis patients : their role in renal transplant outcome
… and transplant outcome include; the antibody class and specificity, the time interval between the positive crossmatch and transplantation and whether the transplant is a first graft or a regraft. In highly sensitized patients the clinical relevance of a positive crossmatch against a particular …
-
Das T-Zell-Rezeptor-Repertoire bei der Polymyositis
… disease cased by CD8+ T lymphocytes that destroy HLA class I-expressing skeletal muscle fibres. Recently we demonstrated that the autoaggressive T lymphocytes in PM muscle are clonally expanded. We employed a new PCR-based method to identify and characterize clonally expanded T cell populations. …
-
The role of the HLA region in Hashimoto’s Thyroiditis
… The aims of this thesis were, i) to investigate HLA class II as a causal factor for Hashimoto’s thyroiditis ii) to investigate the potential role played by HLA class I MICA and MICB in Hashimoto’s thyroiditis. Several predisposing and protective loci within the HLA class II region were determined …
-
Innate Lymphoid Cell Diversity in Pregnancy and Ovarian Cancer
… abundant subset, dNK1, express receptors for HLA class I found on invading extravillous trophoblast (EVT) including Killer-cell Ig-like receptors (KIR), LILRB1 and NKG2A. In contrast to dNK2 and dNK3, dNK1 respond poorly to ‘missing self’ and PMA plus ionomycin treatment. However, upon …
-
Vestigial-Like 1 Is A Shared Targetable Cancer-Placenta Antigen Expressed By Pancreatic and Basal-Like Breast Cancers
… performed tandem mass spectrometry analysis of HLA class I-bound peptides from tumors of PDAC patients. This led to the identification of a shared HLA-A*0101 restricted peptide derived from co-transcriptional activator Vestigial-like 1 (VGLL1), a novel putative TAA demonstrating overexpression …
-
Killer Cell Immunoglobulin-Like Receptors Delineate Distinct Phenotypes and Functions in Human γδ T Cells
Human circulating γδ T cells are broadly classified into three subsets: Vδ1, Vδ2, and Vδ1/2neg populations, with the Vδ2 subset being the most abundant. In this research, I focus on the contribution and interplay of Natural Killer (NK) receptors to the γδ T cell phenotype and function, with …
-
Dissociated expression of granzyme B and IFN-gamma by T lymphocytes in HIV-1 infected individuals and its implications for Tc1 effector diversity
… library included a panel of previously defined HLA class I restricted HIV peptides and an overlapping 20-mer peptide-series that covered the entire gp120 molecule. To characterize the in vivo differentiation state of the T-cells, freshly isolated lymphocytes were tested in assays of 24h …
-
Examination of HIV-1 diversity and evolution by a bioinformatics approach
… of the two proteins, calculated frequencies of HLA alleles targeting CTL epitopes, and compared PS patterns among major subtypes. The results showed that PS pressure was widely dispersed across the entire regions of both HIV-1 Env and Gag proteins, suggesting the conserved regions are under host …
-
Development of a Neoepitope Prioritization Platform to Identify Immunogenic Neoantigens from Oncogenic FGFR3-TACC3 Fusion in Glioblastoma
… spanning the fusion junction were assessed for HLA class I binding using NetMHCpan 4.1, MixMHCpred 3.0, and BigMHC 1.0, alongside an in vitro flow cytometry-based binding assay. Eleven peptides, including 10 fusion-derived neoantigens, were validated as strong binders to HLA-A*01:01. NetMHCpan …
-
Characterizing The Source of Neutrophil Elastase and Proteinase 3 Cross-Presentation In B-Cell Acute Lymphoblastic Leukemia
… PR1 is a nonameric human leukocyte antigen (HLA)-A2 restricted leukemia-associated antigen derived from serine proteases neutrophil elastase (NE) and proteinase 3 (P3). NE and P3 are primarily expressed in cells of myeloid lineage including granulocytes, bone marrow progenitors and myeloid …
-
The Role and Immunogenicity of CBFA2T3-GLIS2 in Pediatric Acute Megakaryoblastic Leukemia
… to recognize polypeptide fragments presented by HLA molecules on the tumor cells. An advantage of this approach is the ability to recognize intracellular tumor specific and tumor associated antigen fragments in addition to extracellular proteins which results in a wider range of targets. To …
Page 1 of 2