Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"HL60"”.
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Opto-Electronic Modulation of Quantum Dots by Cells and Bioactive Molecules
… analysis of optically excited colloidal QDs with HL60, K562, and T98G cell lines are performed. Our results show statistically significant (p < 0.001 and p < 0.0001) quenching of the emission spectra of the colloidal dispersions due to bioactive molecules in common chemotherapeutic drugs and due …
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Zur epigenetischen Inaktivierung der Wnt-Antagonisten SFRP-1, -2, -4 und -5 bei der Akuten Myeloischen Leukämie
… and -5 in the AML cell lines KG1a and HL60 and the Burkitt’s lymphoma cell line Raji by methylation-specific polymerase chain reaction (MSP). Promoter hypermethylation was found for all four SFRP genes in HL60 and Raji and for SFRP-1,-2 and -5 in KG1a. Transcriptional gene silencing as …
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Development of biomimetic microfluidic adhesive substrates for cell separation
… are captured by the receptors were studied using HL60 cells as a model leukocyte cell line and P-selectin as a model receptor. Settling distance of HL60 cells under different shear stresses inside microfluidic channels was identified from the study of convection velocity of cells at different …
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Nanosecond Pulsed Electric Field Effects on Cell Cycle and Apoptosis
… conditions that induce apoptosis in Jurkat and HL60 cells, (2) determine the response of HCT116p53+/+ cells to nsPEFs during DNA synthesis in respect to apoptosis and proliferation at conditions that induce apoptosis in Jurkat and HL60 cells; and (3) determine conditions of nsPEFs that induce …
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Functional Significance of the Upregulation of Adhesion Molecules on Irradiated Endothelial Cells
… and irradiated with a single dose of 10 Gy. HL60 (human promyelocytic leukemia) cells were perfused over the irradiated (IR) endothelial cells in a parallel plate flow chamber at shear stress of 0.5-2.0 dynes/cm 2 . Flow cytometry analysis at 5 hr, 24hr, 48 hr and 72 hr post-irradiation …
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Multi-frequency characterization of single cells through CM factors and dielectrophoresis
… for three different activation levels of HL60 cells treated with Cytochalasin D using the optimal frequency sequence obtained in simulation to determine the differences in discrimination abilities depending on the number of frequencies used. We quantify the discrimination abilities of the …
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AML1/ETO Downregulates the Transcription Factor PU.1 in Acute Myeloid Leukemia
… and inhibits PU.1 induced differentiation in HL60 cells. Overexpression of PU.1 differentiates AML1-ETO carrying Kasumi-1 cells to the monocytic lineage. Thus, PU.1’s function is downregulated in presence of AML1-ETO in acute myeloid leukemia, whereas overexpression of PU.1 can restore normal …
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Investigating the metabolic impact of Metformin and Berberine in combination with Venetoclax for Acute Myeloid Leukaemia treatment
… showed a synergistic cell death response in the HL60 cell line, unlike Berberine and Venetoclax (BBR+Ven). The combination treatments increased lactate production compared to their monotherapy, however Met+Ven increased lactate retention and reduced expression of the lactate efflux protein MCT4, …
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Differenzierungsabhängige Modulation der Zytokin- und Chemokinexpression bei humanen myeloischen Zell-Linien
… anhand von drei myeloischen Zell-Linien (NB4, HL60, K562) untersucht, ob die Zyto- und Chemokinexpression durch eine Differenzierung moduliert wird. Markerzytokine für bestimmte Richtungen der Differenzierung sollten identifiziert und <br>linienspezifische Zytokin- und Chemokinprofile bestimmt …
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Novel Resorcinol Platforms with Pharmaceutical Applications
… viability of two cancer cell lines, MCF-7 and HL60. The results showed a varied profile, ranging from potent antiproliferative activity to compounds with very moderate effects. Additionally the potential antioxidant activity of the compounds was investigated with two in vitro assays and for …
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Funktion und Regulation der Transferrinrezeptorfreisetzung
… Shedding bezeichnete Freisetzungsprozess wird in HL60-Zellen durch eine Metalloprotease vermittelt, die sensitiv gegenüber dem Tumornekrosefaktor ?-Proteaseinhibitor TAPI2 reagiert und sehr wahrscheinlich zur Proteasefamilie der ADAMs zu zählen ist. Der sTfR dient als Marker für Eisenstatus und …
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Generation and therapeutic evaluation of recombinant immunotherapeutics on CD64+ monocytic cell lines and polarized ex vivo differentiated human macrophages
… to IFN-γ stimulated CD64-positive U937 and HL60 monocytic cells but not to antigen-negative cells. The functional (binding) activity of the anti-CD64 fusion proteins demonstrated by flow cytometry confirmed that the H22(scFv) antibody domain of each recombinant protein exhibited a properly …
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The expression of potential molecular candidates for chloride ion channels in primary human granulocytes and granulocytic cell lines
… in granulocytes and eosinophils but not HL60. hBest1 and hBest3 was expressed in all 3 cell types. In granulocytes, flow cytometry demonstrated greater hCLCA1 protein expression intracellularly, compared to hBest1 protein, and greater hBest1 plasma membrane expression compared to hCLCA1 …
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New Types of Morpho-Physiological Changes in Cells Exposed to Nanosecond Pulsed Electric Field
… results show that microvesiculation develops in HL60 and U937 cells in response to Ca<sup>2+</sup> presence during nsPEF exposure. Microvesiculation does not depend on colloid-osmotic swelling (COS). PLBs are produced in U937 cells due to active formation of actin cortex and require the absence …
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Synthetic Studies Towards the Total Synthesis of Apoptosis Inducing Natural Products, Jahanyne and Opaliferin
… the growth of HeLa cells (IC50 1.8 uM) and HL60 cells (IC50 0.63 uM), and was also shown to induce apoptosis in HeLa cells. Jahanyne (18) includes two rare partial structures; a 2-(1-oxo-ethyl)-pyrrolidine (Oep) (blue) unit and a 2,4-dimethyldec-9-ynoic fatty acid moiety (red). A concise and …
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"Ανάλυση έκφρασης μεταγράφων γονιδίων της οικογένειας BCL2 σε ανθρώπινα λευχαιμικά κύτταρα"
… η ανθρώπινη προμυελοκυτταρική σειρά HL60 ως πειραματικό σύστημα. Πραγματοποιήθηκε απομόνωση RNA, σύνθεση cDNA με χρήση oligo-dT εκκινητών, ενίσχυση γονιδιακών στόχων με PCR και ποσοτικός προσδιορισμός προϊόντων με φθορισμομετρία. Τελικό στάδιο αποτέλεσε η επιλογή γονιδίου με διακριτό …
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Avaliação da citotoxicidade e da indução de apoptose de adutos da reação Morita-Baylis-Hillman derivados da isatina em células tumorais
… a seis linhagens tumorais (MCF-7, HEP-2, HepG2, HL60, K562 e NCI H292), nos quais os 8 mais promissores foram testados em células mononucleares do sangue periférico (CMSP). As CI50s determinadas pelo método do MTT após 72h para células tumorais dos adutos mais citotóxicos variaram entre 0,044uM e …
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Prkca: Identification of A Novel Downstream Target of Wt1
… following RPPA analysis of protein expression in HL60 leukemia cell lines with lentiviral delivered shRNA knockdown of <em>WT1</em> and shRNA knockdown of <em>PRKCα</em>.</p>
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Automatic Label-Free system for cell viability on-a-chip [Sistema automatico Label-Free per la determinazione della vitalità cellulare su chip]
… validate su diverse linee cellulari, tra cui HL60 e HeLa in differenti stati di vitalità, e confrontate con il test standard MTT, evidenziando una forte coerenza tra gli indicatori di vitalità metabolici e meccanici. Inoltre, per superare le esigenze computazionali intrinseche …
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THE INFLUENCE OF MELANOMA STEM CELLS ON TUMOR MICROENVIRONMENT REMODELING: EXPERIMENTAL INSIGHTS FROM IN VITRO STUDIES
… Using a neutrophil-like model obtained from HL60 cell line, it was found that melanoma SCs activated these immune cells, as indicated by the up-regulation of the CD66b and CD11b markers and induce their recruitment. Secretome analysis revealed that melanoma SC produce TGF-β, IL-6, and IL-8 …