Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"HL-1 cells"”.
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Calcium Influx via the T-Type Calcium Channel Plays a Permissive Role in Proliferation of Mouse Embryonic Hl-1 Cells
… cell types. An atrial myocyte cell line (HL-1) that selectively expresses T-type calcium current was employed to show that inhibiting calcium influx through the T-type calcium channel inhibits cellular proliferation. Drug dosage studies demonstrate that the T-type calcium channel …
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Myocardial ischemia and reperfusion injury, clinical and experimental studies
… chain reaction. Mouse cardiomyocytes (HL-1 cells) were analysed after exposition to hypoxia. The HL-1 cells were further investigated with aspects of FKBP12 and FKBP12.6 release in hypoxia, energy depletion, acidosis, ROS activation and re-establishing of physiologic conditions, …
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Silicium Nanodrähte für die extrazelluläre Ableitung elektrischer Aktivität
… nanowires are promising candidates for highly sensitive biosensors. We designed and fabricated nanowire transistors suitable for the extracellular detection of electrical activity. These sensors were characterized thoroughly and tested with HL-1 and HEK cells. The tests with HL-1 cells …
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Organization of energy transfer and feedback regulation in oxidative muscle cells
… has been hypothesized that in oxidative muscle cells the mitochondria and ATPases form tight complexes, termed as the intracellular energetic units (ICEUs). At present the structure and molecular basis of the ICEUs are unclear and therefore an object of active research. Aims of the study: 1) To …
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Communicating with electrogenic cells
… and reliable communication with electrogenic cells is comprised of several techniques from dierent elds of research. Cellular signals need to be sensed and recorded utilizing extracellular recording devices with a temporal resolution that is higher than the duration of a single action …
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ROLE OF ENDOTHELIN-1 IN THE REGULATION OF THE SWELLING-ACTIVATED Cl- CURRENT IN ATRIAL MYOCYTES
… Cl- current that was fully blocked by the highly selective ICl,swell inhibitor DCPIB and by osmotic shrinkage. Selective ETA blockade (BQ123), but not ETB blockade (BQ788), fully suppressed the ET-1-induced current. ET-1-induced ICl,swell was abolished by blockade of EGFR kinase (AG1478) and …
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The process of autophagy in an in vitro model of myocardial ischemia-reperfusion injury
… of ischemia (hypoxia) involving exposure of HL-1 murine atrial cardiomyocytes to two concentrations of oxygen (0.5% and 2.0%) and 2-deoxyglucose. </p> <p>Hypoxia, irrespective of the oxygen concentration, caused a dramatic drop in cellular ATP and an increase in the phosphorylation of AMPK …
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Nesfatin-1 Regulation of Cardiovascular Functions in Zebrafish and HL-1 Cardiomyocytes
… was detected in the cytoplasm of mouse HL-1 cardiomyocytes. High glucose increased NUCB2 mRNA expression in HL-1 cells. Genes involved in apoptosis, including Akt1, Caspases 1, 2, 3, and TNF were upregulated in the presence of 10 nM nesfatin-1. We also observed that NUCB2 mRNA expression …
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The interplay between pro-death and pro-survival signaling pathways converging at mitochondria in myocardial Ischemia/Reperfusion : Apoptosis meets Autophagy
… the single cell. Simulated I/R (sI/R) of cardiac HL-1 cells was employed as an in vitro model of I/R injury to the heart. To assess macroautophagy autophagosome generation and degradation (autophagic flux) was quantified, as determined by steady-state levels of autophagosomes in relation to …