Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"HL-1 cardiomyocytes"”.
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Nesfatin-1 Regulation of Cardiovascular Functions in Zebrafish and HL-1 Cardiomyocytes
… physiology. We found that zebrafish cardiomyocytes express NUCB2 mRNA and nesfatin-1-like immunoreactivity. While NUCB2 mRNA was lower in unfed fish at 1 hour post-regular feeding time compared to the fish at 0 hour time point, it was observed that chronic food deprivation did not …
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Pathophysiological changes in cardiomyocyte metabolism and bioenergetics during stress-induced cardiomyopathy.
… focused on metabolic and bioenergetic changes in cardiomyocytes during stress exposure. Stress exposure leads to pathophysiological changes in myocardium, which can lead to heart failure. It is important to know exact pathophysiological changes to prevent the development of heart failure. The main …
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Calcium Channel Gamma(6) Subunit: In Search of Its Functions and Mechanisms of Action
… that gamma 6 also inhibits LVA currents in HL-1 cardiomyocytes, confirming its function in native cells. Previous studies from our lab indicated that the first transmembrane domain of gamma6 is responsible for its inhibitory function. Using mutational analysis, we further identified the …
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Mitochondrial Dynamics: Exploring A Novel Target Against Myocardial Ischemia-Reperfusion Injury
… model of hypoxia-reoxygenation (HR) in cultured HL-1 cardiomyocytes, we tested three hypotheses:</p> <p>I. subcellular redistribution of DRP1 is i) triggered by HR, and ii) plays a mechanistic role in HR-induced cytochrome c release and cell apoptosis; </p> <p>II. inhibition of DRP1 translocation …
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Investigation into the mechanism of Nox2 NADPH oxidase-dependent signalling in doxorubicin cardiotoxicity
… signalling mechanisms in DOX-treated cardiomyocytes in vitro. Wild type (WT) and Nox2-/y mice were treated with or without DOX (4mg/kg) and studied after 4 weeks. DOX-induced cardiac contractile dysfunction and cardiomyocyte remodelling was attenuated in Nox2-/y as compared to WT mice. …