Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"HK2"”.
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Investigating HK2 as a potential therapeutic target in glioblastoma
… for the advancement of treatment. Hexokinase 2 (HK2) has a prominent role in glycolysis, acting as the rate-limiting step in the pathway. HK2 is highly expressed in many cancers and its role as the rate-limiting step of glycolysis may potentially contribute to tumour growth. Overexpression of HK2 …
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The Kallikrein-Related Peptidases hK2 and PSA with Emphasis on Genetic Variation, Secretion, and Sperm Motility
… antigen (PSA) and human glandular kallikrein 2 (hK2) are secreted by the prostate into seminal plasma and through leakage into blood. This leakage increases rapidly in prostate disease, and PSA is used worldwide as a marker of prostate cancer. PSA is activated in vitro by hK2, and cleaves the …
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The development of novel metabolic therapies for the treatment of glioblastoma
… key first rate-limiting enzyme of glycolysis, HK2. HK2 knockdown was further demonstrated to significantly inhibit the glycolytic activity of these cell cultures upon the seahorse XFp. These findings importantly reaffirmed HK2’s role as a key driver of the elevated glycolysis unique to …
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Regulation of hnRNP A1 Cellular Localization by Protein Kinases and its Biological Impact
… I have identified and validated the role of HK2 in hnRNP A1 cellular localization by immunofluorescence microscopy, by analysis of HRV infection and by siRNA-based screening. These studies show that decreased HK2 protein levels lead to decreased cytoplasmic accumulation of hnRNPA1 during …
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DIFFERENTIAL EFFECTS OF GROWTH FACTORS ON GLYCOLYSIS IN OVARIAN CANCER CELLS
… EGF was the robust induction of hexokinase 2 (HK2) that stimulates irreversible entry of glucose to the glycolytic pathway. However, insulin and IGF-1 only weakly induced HK2 expression. Further experimental evidence using HK2 inhibitors indicated that HK2 up-regulation was the critical …
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Study of the differential compartmentation and functions of hexokinase isoforms and implications for cancer metabolism
… glycolytic phenotype is hexokinase 2 isoform (HK2), which is significantly overexpressed in many tumors but not in normal adult tissue. Several small molecule inhibitors targeting HK have exhibited promising anticancer activity. However, these small molecule inhibitors cannot differentiate …
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Role of PBRM1 in regulation of the HIF pathway
… contributes to the hypoxia induced expression of HK2 and PHD2 genes, possibly by interacting with HIF1 at HRE sites in the promoters of these genes.
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Acute and chronic heat stress alters the metabolic profile of skeletal muscle in growing swine
… Rs6 and gene expression of Cox5B, CytB, EEF2, HK2, MURF, ND1, PGC-1α, SDHA, and TFAM during the acute heat stress study. Differences (p<0.05) were observed in protein abundance of 4eBP1, total Akt, and p-Rs6 and gene expression of CytB, MURF, and PGC-1α during the chronic heat stress study. …
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Polyploidy and Mitotic Cell Death are Two Distinct HIV-1 Vpr-Driven Outcomes in Renal Tubule Epithelial Cells
… lentiviral vectors expressing Vpr in the HK2 human tubule epithelial cell line. Using FACS, fluorescence microscopy, and live cell imaging I show that G2 escape immediately precedes a critical junction between two distinct outcomes in Vpr+ RTECs: mitotic cell death and polyploidy. Vpr+ …
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ApoE2-Mediated Neuroprotection Against Alzheimer’s Disease: from Mechanism to Translation
… signaling activity modulated hexokinase 2 (HK2) protein expression but not HK1; HK2 is known to play a crucial role in cell survival, proliferation, and development. In the second chapter we aimed to investigate the ApoE isoform specific regulation on synaptic function in human ApoE knock-in …
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Superoxide via Sp3 Transcription Factor Up-Regulates Renal AT1 Receptor Function and Contributes to Hypertension
… pressure. Results from cell culture studies (HK2 cells) demonstrated that SOD-inhibitor DETC but not hydrogen peroxide significantly increased fluorescence levels of superoxide probe dihydroethidium (DHE). Similarly, H2O2, but not DETC, treatment increased the fluorescence of the …
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Therapeutic Effects and Targeted Delivery of Eupenifeldin in Castration-Resistant Prostate Cancer
… key glycolytic regulators, including GLUT-1, HK2, and PKM2, which are critical for glucose uptake and metabolism. This metabolic stress was accompanied by a substantial increase in reactive oxygen species (ROS) production, further contributing to cellular damage and apoptosis. The addition of …