Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"HIV-associated neurocognitive disorder"”.
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Clinical interventions for HIV-associated neurocognitive disorder (hand) : a systematic review
… the widespread use of antiretroviral therapy, HIV-associated neurocognitive disorder (HAND) continues to be one of the most common central nervous system (CNS) complications of human immunodeficiency virus (HIV), with the prevalence of the disorder remaining stable at pre-cART levels. HAND …
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Hiv And Antiretrovirals In The Central Nervous System: Molecular Mechanisms Of Cognitive Impairment
HIV-associated neurocognitive disorder (HAND) describes a wide range of cognitive impairments experienced by up to 55% of HIV+ individuals despite viral suppression by combined antiretroviral therapy. Reasons for the persistence of this disease are unknown, but may be related to both the presence …
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MODELING PRO-INFLAMMATORY CROSSTALK BETWEEN MICROGLIA AND ASTROCYTES DURING HIV INFECTION
HIV-Associated neurocognitive disorder (HAND) is a spectrum of cognitive deficits observed in 50% of people living with HIV (PWH). HAND is associated with viral transcription in the central nervous system (CNS) and neuroinflammation, though the mechanisms that drive this pathology remain poorly …
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Unravelling the molecular mechanisms of HIV associated neurocognitive disorders through mass spectrometry-based proteomics
… of human immunodeficiency virus type 1 (HIV)-positive individuals are affected by the cognitive, motor and behavioural dysfunction that characterises HIV associated neurocognitive disorders. While the molecular aetiology of this important HIV complication remains largely uncharacterised, …
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A Transferrin conjugated nanoemulsion system for brain delivery of antiretroviral therapy
HIV- associated neurocognitive disorder (HAND), also known as HIV encephalopathy and AIDS dementia, is one of the critical complications of HIV infection that causes severe morbidity and even shortens survival. This complication is challenging to treat because most of the antiretroviral therapeutic …
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The Role of Specific Integrase Strand Transfer Inhibitors (INSTIs) in the Alteration of Oligodendrocyte Maturation and Myelination in Hand
… infected with human immunodeficiency virus-1 (HIV-1) worldwide. Thankfully, the development of combined antiretroviral therapy (cART) regimens has decreased mortality and significantly improved the overall quality of life for these patients. However, approximately half of all patients …
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An investigation of a neuro-inflammatory profile of HIV-associated neurocognitive disorders
Background HIV-associated neurocognitive disorder (HAND) is the consequence of the effects of HIV-1 within the central nervous system (CNS). HIV-associated neurocognitive impairment differs in severity with milder forms presenting in 50% of people living with HIV (PLWH), regardless of treatment …
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HIV-1 gp120 and Methamphetamine-mediated Induction of Proinflammatory Cytokines/chemokines and Oxidative Stress in Astrocytes: Implications in Neuroinflammation
HIV associated neurocognitive disorder (HAND) remains a major concern for patients infected with HIV. The viral envelope protein, gp120 has been extensively studied and some of its neurotoxic effects are due to the increased expression of various proinflammatory cytokines. Additionally, it has been …
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A Novel Elvitegravir Nanoformulation for Drug Delivery Across the Blood-Brain Barrier to Suppress HIV-1 in Macrophages and Microglia
… (ART) has remarkably decreased the morbidity associated with HIV-1 infection. However, the prevalence of HIV-1-associated neurocognitive disorders (HAND) is still increasing. The appearance and persistence of HAND are partially due to the entry of HIV-1-infected monocytes into the brain. …