Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"HIV-Tat"”.
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HIV Tat Protein Activates Endothelial Cells through NFκB and MAP Kinase Pathways.
<p>HIV infection has been shown to predispose patients to accelerated development of heart disease. One mechanism for this pathology may involve endothelial activation either by HIV itself or by its secreted proteins, gp120 (a viral envelope protein) and tat (a protein that upregulates …
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A network analysis based proteomic and transcriptomic investigation into HIV-Tat induced neuronal dysfunction and the neuroprotective effect of lithium
HIV-associated neurocognitive disorders (HAND) affect up to 70% of HIV positive individuals and are the leading cause of dementia in patients under 40 years. Despite this, the molecular mechanisms involved in the onset of HAND are not well understood. Among a number of plausible etiological agents …
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Unravelling the molecular mechanisms of HIV associated neurocognitive disorders through mass spectrometry-based proteomics
… of human immunodeficiency virus type 1 (HIV)-positive individuals are affected by the cognitive, motor and behavioural dysfunction that characterises HIV associated neurocognitive disorders. While the molecular aetiology of this important HIV complication remains largely uncharacterised, …
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In vitro-Selektion am lentiviralen Transaktivator-Protein aus HIV-1
… konnte für das lentivirale Transaktivatorprotein HIV-1-Tat ein ternäres Phagen-Display-System etabliert werden. Die Bindung von phagenpräsentiertem HIV-Tat an HIV-TAR-RNA erfolgt im Phagen-Display nur mit geringer Affinität. Durch die Erweiterung des Tat-TAR-Phagen-Displays mit dem zellulären …
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Gene Expression Changes in Immune Cells During Human Immunodeficiency Virus 1 (HIV-1) Infection
… it is possible to describe not only the current states the cells are in, but also to extrapolate the proximal signals that resulted in the observed patterns. In the studies described herein, we have applied this approach to better understand the alterations in the immune function that occur in HIV …
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Memory of Chirality in 1,4-Benzodiazepin-2-ones
… agents (Clonopin ®), they have shown activity as HIV Tat antagonist, ras farnesyltransferase inhibitors in cancer cells, and antiarrhythmic agents. Because of the utility of this scaffold in the area of medicinal chemistry, it has served as a template in libraries for tens of thousands of …
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REGULATED UPTAKE OF BIOPOLYMERS Role of cell surface proteoglycans Implications for drug and gene delivery
… such as bacterial toxins and viral proteins. The HIV-1 TAT protein was shown to enter cells and to target their nuclei, thus acting as a paracrine transcription factor, a finding that initiated the field of so called cell penetrating peptides (CPPs). Due to their ability to efficiently deliver …
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Mechanistic study of aryl hydrocarbon receptor nuclear translocator (ARNT)-mediated signaling
… transient transfection. We further utilized HIV TAT protein transduction domain to deliver 6His-TAT-Ainpl into three different cancer cell lines (Hep3B, HeLa, MCF-7), and found that 6His-TAT-Ainpl co-localizes with ARNT in the cell nucleus. 6His-TATAinpl can be detected inside the cells after …
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Investigating the functionality of African-specific variants in the TGFB1 regulatory region and their potential role in HIV-associated kidney complications
… disease complications in South Africans, such as HIV-associated nephropathy (HIVAN), may be influenced by functional genetic variations in TGFB1. To address this, the African-specific TGFB1 haplotypes containing singular, or combinations of, -1287 G>A (rs11466314), -1154 C>T (rs35318502), -387 C>T …
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Enzymatic Disassembly of Promoter Bound 7SK snRNP Drives Transcription Elongation of HIV and Cellular Genes
… expression of the human immunodeficiency virus (HIV) and cellular primary responsive genes (PRG’s) is regulated at the step of transcription elongation. Shortly after transcription initiation, RNA Polymerase II (Pol II) pauses and it only enters into productive elongation after inducible …
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Simultaneous Delivery of CRISPR/Cas Complexes and Donor DNA Using Cell-Penetrating Peptide-Adaptors
… to treat many human diseases caused by these mutations. Research using CRISPR/Cas systems in the treatments of many of the genetic diseases has resulted in misfortunes (such as toxicity to the patient or new diseases) because of the method of delivery such as viral delivery. </p> <p>The current …
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Synthese und Cytotoxizität membranpermeabler Phallotoxine
… und (3) die Kopplung an trojanische Peptide, wie HIV-Tat-Peptid oder Arginin8, über Disulfid-haltige Linker. Alle drei Strategien lieferten Phallotoxin-Derivate mit Cytotoxizitäten, die bis zu 1000-mal höher waren als die des natürlichen Phalloidins. Die Cytotoxizität wurde anhand der …
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Novel cell-penetrating peptide-based vectors for siRNA delivery
… peptide sequence (either AntpHD, Penetratin, HIV-Tat or EB1) fused to either the first dsRNA binding motif 1 (DRBM) or the tandem motifs (DRBMx2) from human PKR, which bind dsRNA with high avidity in a sequence independent manner. A panel of constructs were cloned, expressed in a bacterial …
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Strukturelle Untersuchung des Antiterminationskomplexes von EIAV
… der Resonanzen von 13C/15N-markiertem EIAV-Tat. Zum ersten Mal konnten mit Hilfe dieser Zuordnung strukturelle Veränderungen des Proteins bei der Wechselwirkung mit TAR-RNA, Cyclin T1 und dem Inhibitor TF53 auf der Basis einzelner Aminosäuren direkt in einem 15N-1H-HSQC-Spektrum beobachtet …
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REGULATION OF YKL-40 IN STERILE INFLAMMATION AND ITS ROLE IN GLIOBLASTOMA IN VIVO
… Alzheimer disease, viral encephalitis, HIV-associated dementia, brain infarction, and traumatic brain injury. YKL-40 is also expressed by several solid tumors, such as osteosarcoma, ovarian carcinoma and glioblastoma multiforme (GBM). It promotes the migration and invasion of astrocytes …
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Integrin-ligand interactions and cytokine production by monocytic cells
… that have been described for the binding of the HIV Tat protein. The interaction between sCD23 and its integrin receptors is important in the regulation of cytokine production by monocytic cells. Most monocytic cells will express a combination of the different CD23-binding integrins …
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Neuroinflammation and comorbid depression: a role for interleukin-1 beta converting enzyme and indoleamine 2,3-dioxygenase
… Parkinson’s or human immunodeficiency virus (HIV) disease display a higher prevalence of comorbid depression during their life span. Common in these neurodegenerative disorders is inflammation within the central nervous system or neuroinflammation. Neuroinflammation is recognized as an …