Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"HIV-TB"”.
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The transciptomic landscape of HIV-TB
… 1 of this thesis I provide a broad overview of HIVTB with an emphasis on systems approaches followed by an overview of a systems-level study aiming at addressing hypotheses relating to transcriptional differences in active tuberculosis and HIV-1 infection, measured in blood and the site of …
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Characterising the immunometabolic profile of HIV/TB co-infection
… between the human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) during co-infection of a host is well established. While this synergy is driven by immunological deterioration, the metabolic mechanisms that contribute to the …
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Immunoproteome of anti-TB drug associated DRESS in HIV TB co-infection
… Systemic Symptoms (DRESS) occur among HIV-infected patients. We sought to characterize the immunoproteomic profile of DRESS to first-line TB drugs in HIV infected cases. We hypothesize that differentially regulated proteins would be found interindividually and with disease evolution …
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Characterization of Mycobacterium tuberculosis-specific Th22 cells in HIV-TB co-infection
Tuberculosis (TB) remains the infectious disease causing the greatest global mortality, with an estimated 10 million incident cases of TB and 1.45 million deaths in 2018. Although there is a cure for TB, the success of the treatment is hampered by multidrug resistant TB and HIV infection. There is …
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Investigating defects in monocyte responses to Mycobacterium tuberculosis in HIV-TB co-infection
Includes abstract. Includes bibliographical references.
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Modelling hepatotoxicity in HIV/TB co-infected patients: extensions of the Cox Proportional Hazards Model
… patients who are co-administering Tuberculosis (TB) treatment and the antiretroviral therapy (ART) for the Human Immunodeficiency Viruses (HIV). If severe, hepatotoxicity sometimes necessitates cessation or interruption of treatment. Therefore, understanding, monitoring and managing …
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Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation
Both human immunodeficiency virus (HIV) infection and tuberculosis (TB) are complicated by a painful distal sensory polyneuropathy (DSP) that may be due to virus-related HIV-DSP, antiretroviral toxic neuropathy (ATN) or isoniazid-induced peripheral neuropathy (INH-PN). In co-infection with and …
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Associated factor of mortality rate amongst patients with AIDS and HIV-TB co-infections using zero inflated negative binomial method
… regression model for mortality rate among AIDS/HIV co-infection patients and to compare Zero-Inflated Negative Binomial death rate regression with Negative Binomial death rate, which is the best model when a data existing zeroes values. It follows by to determine overdispersion in the model. …
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The diagnostic accuracy of abdominal ultrasound findings in patients evaluated for peripheral lymphadenopathy in a high HIV TB endemic population
Background: Extrapulmonary tuberculosis (EPTB) is common among people living with HIV (PLWH). The abdominal ultrasound is an accessible investigation frequently employed to support the diagnosis of EPTB but may lead to misdiagnoses of diseases with overlapping clinical features, such as lymphoma. …
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Investigation of HIV-TB co-infection through analysis of the potential impact of host genetic variation on host-pathogen protein interactions
HIV and Mycobacterium tuberculosis (Mtb) co-infection causes treatment and diagnostic difficulties, which places a major burden on health care systems in settings with high prevalence of both infectious diseases, such as South Africa. Human genetic variation adds further complexity, with variants …
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Patterns of HIV, TB, and non-communicable disease multi-morbidity in an informal peri-urban setting in Cape Town, South Africa
… in Cape Town. Adults with at least one of HIV, tuberculosis (TB), diabetes (T2DM), and hypertension (HPT) were identified between Sept 2012-May 2013 on electronic databases. Using unique patient identifiers, drugs prescribed across all facilities in the province were linked to each patient …
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Expectations and Preferences of Parents and Adolescents Regarding Feedback of Individual Genetic Findings in an HIV-TB Genomic Research Project in Botswana
… feedback of individual genetic findings in an HIV-TB genomics research project in Botswana. A qualitative study methodology involving deliberative focus group discussions (dFGDs) and in-depth interviews (IDIs) was used. Participants for this study were adolescents involved in an HIV-TB genomics …
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Clinical presentation and diagnostic work up of suspected pulmonary embolism in a district hospital emergency centre serving a high HIV/TB burden population
… in the South African environment, where HIV and TB are highly prevalent. Both conditions are known to induce a hyper-coagulable state. Methods: This study was a retrospective chart review of patients with suspected PE that had CTPAs performed from October 2013 to October 2015 at …
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Associations between HIV, TB and psychological distress among a sub-sample of a nationally representative study of South African adults: a secondary data analysis
… that it is the epicentre of the global HIV and TB pandemics. Moreover, the burden of mental ill-health is a growing concern due to its prominent association with infectious diseases. While global research evidence hasshed some light on the effects of psychological distress on …
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Risk factors for deep vein thrombosis in a South African public hospital
The evidence suggests an association between HIV, TB and DVT. There are no studies of this link in the Southern African setting, where the incidence of both of these conditions (HIV and TB) is high. We therefore undertook a study to define the incidence of HIV and TB in patients with confirmed DVT …
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Diagnosis, treatment and determinants of mortality in patients hospitalized with HIV-associated tuberculosis
Background: HIV-associated tuberculosis (HIV-TB) comprises 9% of global tuberculosis cases but contributes a disproportionate 17% of tuberculosis deaths. Tuberculosis is the leading cause of death, hospitalization and in-hospital death in HIV-positive patients world-wide with case fatality rates in …
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Strategies for optimising TB-HIV co-treatment in children and adolescents with drug-susceptible tuberculosis on rifampicin-based standard regimens
Children with HIV are highly susceptible to tuberculosis (TB) and often require concurrent antiretroviral treatment (ART) and antituberculosis therapy. However, rifamycins, the key drugs for TB treatment, significantly interact with many ART classes, necessitating adjustments to one or both …
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The spectrum of HIV-related kidney disease in South Africa
The spectrum of HIV-related kidney disease in South Africa Associate Professor Nicola Wearne Background: HIV is associated with a spectrum of kidney diseases, including HIV-associated nephropathy (HIVAN), opportunistic infections, including tuberculosis (TB), and adverse effects of drugs and immune …
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The effect of antiretroviral treatment on HIV associated tuberculosis incidence and outcomes in the Free State Province, South Africa.
Of people co-infected with HIV and tuberculosis (TB) globally, 79% are in Sub-Saharan Africa. While scale-up of antiretroviral treatment (ART) is reducing mortality in the region, there is little direct evidence of the magnitude of its effect on mortality in people coinfected with TB, or on TB …
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