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Showing 1 to 3 of 3 for “"HIV-Nef"”.
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Mechanisms of HIV-Nef Induced Endothelial Cell Stress: Implications of HIV-Nef Protein Persistence in Aviremic HIV Patients
HIV-associated cardio-pulmonary vascular pathologies such as coronary artery disease, pulmonary hypertension and emphysema remain a major issue in the HIVinfected population even in the era of antiretroviral therapy (ART). The continued production of HIV encoded pro-apoptotic protein, such as Nef …
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Etablierung eines infizierbaren Kleintiermodells zur Untersuchung von HIV-Nef
Das virale Nef-Protein ist eine wichtige Determinante für die Infektiosität und die Pathogenese des humanen und simianen Immundefizienzvirus. Die Bedeutung des Nef-Proteins wird durch Studien an nef-transgenen Mäusen, die eine AIDS-ähnliche Krankheit entwickeln, demonstriert. Um Funktionen von Nef …
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The mechanism of HIV-1 Nef-mediated downregulation of CD4
Nef, an accessory protein of HIV-1, is a critical determinant of viral pathogenicity. The pathogenic effects of Nef are in large part dependent on its ability to decrease the amount of CD4 on the surface of infected cells. Early studies suggested that Nef induces downregulation by linking the …