Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"HIV-2"”.
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STUDIES OF THE DIMERIZATION AND PACKAGING SIGNALS IN HIV-2 RNA
… in the 5' untranslated leader region (5'UTR) of HIV genomic RNA is essential for understanding viral replication because the 5'UTR regulates several essential functions by the alternate presentation and sequestration of signals through conformational changes. Our main focus in this study was to …
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STUDIES OF THE DIMERIZATION AND PACKAGING SIGNALS IN HIV-2 RNA
… in the 5' untranslated leader region (5'UTR) of HIV genomic RNA is essential for understanding viral replication because the 5'UTR regulates several essential functions by the alternate presentation and sequestration of signals through conformational changes. Our main focus in this study was to …
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Charakterisierung einer Hüllprotein-vermittelten Restriktion von HIV-2 in humanen Zellen
Die Erforschung von Restriktionen der HIV-Infektion spielt eine wichtige Rolle für die Aufklärung und das Verständnis von Virus-Wirt-Interaktionen und liefert neue Ansätze für die Entwicklung antiviraler Therapien. In der vorliegenden Arbeit wurde die Restriktion eines HIV-2 Isolates in humanen …
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Characterization of 5 UTR splicing and the CGI in HIV-2 RNA
<p>HIV-2 tightly regulates several steps of its replication cycle via regulatory elements found within the 5 untranslated region of HIV-2 genomic RNA. Two elements of interest are the 5 UTR intron and the proposed long distance base pairing interaction between the C-box and G-box termed the CGI. …
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Characterization of 5 UTR splicing and the CGI in HIV-2 RNA
<p>HIV-2 tightly regulates several steps of its replication cycle via regulatory elements found within the 5 untranslated region of HIV-2 genomic RNA. Two elements of interest are the 5 UTR intron and the proposed long distance base pairing interaction between the C-box and G-box termed the CGI. …
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HIV-1, HIV-2 and other Sexually Transmitted Infections in Guinea-Bissau, West Africa
HIV-1 is dominating the global HIV pandemic, while HIV-2 is mainly confined to West Africa. The highest HIV-2 prevalence figures have been reported from Guinea-Bissau. While HIV-1 infection almost invariably leads to progressive immune dysfunction and AIDS, HIV-2 infection is characterised by a …
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Structure and dynamics of the HIV-2 TAR RNA-argininamide complex by NMR spectroscopy
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1998.
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HIV-1 evolution, disease progression and molecular epidemiology of HIV-1 single and HIV-1 and HIV-2 dual-infected individuals in Guinea-Bissau
… related human lentiviruses known today, HIV-1 (which is pandemic) and HIV-2 (which mainly is confined to West Africa), are the causative agents of AIDS. Progressive immune dysfunction and AIDS develop in most cases of untreated HIV-1 infection, but only in approximately 25-30% of HIV-2 …
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Effect of Human Immunodeficiency Virus Infection on Human Papillomavirus Clearance among Women in Senegal, West Africa
… were tested for Human Immunodeficiency Virus (HIV) upon enrollment, as well as were tested HPV at baseline and during follow up. The 2-year cumulative incidence of clearance of type-specific HPV infection was estimated by Kaplan-Meier methods. Marginal Cox proportional hazards models stratified …
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Studies On The Determinants Of HIV Mutagenesis And Strategies For Its Enhancement
Human immunodeficiency virus type-1 (HIV-1) is one of the fastest evolving entities on earth, due in part to a mutation rate that is at least 10,000-fold higher than that of eukaryotic genomic DNA. The adaptability of HIV-1 prevents clearance of the virus by the immune system, promotes drug …
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SCREENING FOR POTENTIAL ANTIBACTERIAL AGENTS AND THE APPLICATION OF ISOTOPIC LABELS FOR THE CHARACTERIZATION OF THEIR EFFECTS ON THE DYNAMICS OF THE BACTERIAL 16S RIBOSOMAL RNA
… trans-activation responsive RNA element of the HIV-2 promoter and human hepatitis B virus encapsidation signal epsilon element.
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The G-protein coupled receptor CMKLR1/ChemR23: Studies on gene regulation, receptor ligand activation, and HIV/SIV co-receptor function
… in human and simian immunodeficiency virus (HIV-1 and SIV)-infection of CD4+ immune cells. We have described the genomic organization of cmklr1 in mouse and analysed the regulatory mechanism behind the corresponding receptor expression. Two transcripts of mouse cmklr1 have been identified, …
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Investigating the Role of Stem-Loop 1 in the Assembly Process of HIV-1
An important step in the production of infectious HIV-1 particles is maturation of the virus core. This process is completed by cleavage of the capsid (CA) domain of Gag, from its precursor, CA-SP1, by the viral protease. Large deletions in stem-loop 1 (SL1) in the 5’ untranslated region (UTR) of …
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A Novel Role for and Potential Therapeutic Targeting of Heme Oxygenase-1 in HIV Neuropathogenesis
HIV-associated neurocognitive disorders (HAND) affect up to 50% of HIV-infected adults despite potent viral suppression with antiretroviral therapy (ART) and are associated with persistent neuronal damage, monocyte/macrophage activation, chronic inflammation, and oxidative stress. Heme oxygenase-1 …
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HIV Reverse Transcriptase Fidelity And Inhibition Are Modulated By Divalent Cations In A Concentration-Dependent Manner In Vitro
Human immunodeficiency virus (HIV) rapidly evolves through generation and selection of mutants that can escape drug therapy. This process is fueled, in part, by the presumably highly error prone polymerase reverse transcriptase (RT). Fidelity of polymerases can be influenced by cation co-factors. …
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Herstellung und Charakterisierung eines anti-HIV-Inhibitors basierend auf modifiziertem Serum Albumin
… (molares Verhältnis HSA zu HOCl 1:1000) an das HIV-1 gp120 bindet, wurde es VEBP (Virus Envelope Bindendes Protein) genannt. In einem Synzytien-Test wurde die Wirksamkeit des VEBP gegen HIV-1 überprüft. Zellen, die CD4, CXCR4 und CCR5 exprimieren, wurden mit einem gp160-Expressionsvektor …
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Fatores preditivos para tuberculose em crianças infectadas pelo Vírus da Imunodeficiência Humana
… pelo Vírus da Imunodeficiência Humana (HIV) em um hospital de nível terciário da África subssariana. Dela fazem parte quatro artigos: 1- Revisão de literatura sobre a problemática da co-infecção Mycobacterium tuberculosis / Vírus da Imunodeficiência Humana (HIV), com enfoque nos aspectos …
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Determining and characterizing immunological self/non-self
… low host-similarity (i.e., non-overlaps) between HIV-1 and human proteomes at the 7-mer level. Results show that the correlation between these two regions is not statistically significant. In addition, pairs involving human and human viruses are explored. For these pairs, one graph for each k-mer …
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The Effect of an Educational Intervention on the Sexual Perceptions and Practices of Adolescents in Trinidad and Tobago
… Human immunodeficiency virus (HIV) or acquired immune deficiency syndrome (AIDS) is one of the fastest spreading infectious diseases in the Caribbean, and is second only to Sub-Sahara Africa in the prevalence of HIV/AIDS cases. Trinidad and Tobago is the southernmost twin island …