Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"HIV-1 vaccines"”.
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The development of novel HIV-1 vaccines using modified recombinant BCG
… AIDS related deaths in 2014, an efficacious HIV1 vaccine is urgently needed. The UCT Human Immunodeficiency Virus (HIV) Vaccine Development Group has focussed on understanding novel HIV-1 vaccine vectors, such as modified BCG, combined with modified vaccinia Ankara in the context of …
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Pre-clinical assessment of novel candidate HIV-1 vaccines using the Chacma baboon
Includes bibliographical references (leaves 176-221).
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An investigation of memory T cell phenotypes in peripheral blood of Chacma baboons after immunisation with candidate HIV-1 vaccines
Previous studies from the HIV Vaccine Development Group at the University of Cape Town have reported that immunisation with recombinant modified vaccinia Ankara (SAAVI MVA-C) or DNA prime and Pr55 Gag virus-like particle (VLP) boost based on HIV-1 subtype C are able to successfully induce vaccine …
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HIV-1 evolution, disease progression and molecular epidemiology of HIV-1 single and HIV-1 and HIV-2 dual-infected individuals in Guinea-Bissau
… related human lentiviruses known today, HIV-1 (which is pandemic) and HIV-2 (which mainly is confined to West Africa), are the causative agents of AIDS. Progressive immune dysfunction and AIDS develop in most cases of untreated HIV-1 infection, but only in approximately 25-30% of HIV-2 …
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Attenuated Salmonella Typhimurium Can Be Used to Transduce Human Dendritic Cells Towards Vaccination Against HIV-1
… bacteria bearing a eukaryotic vector encoding HIV-1 env showed expression of the viral gene. Macrophages were also infected with bacteria harboring vectors encoding SIV env and HIV-1 tat, then subjected to lysis, RNA extraction and RT-PCR. In this way, conceptual proof of the system was …
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Prokaryotic Production of Human Immunodeficiency VirusType 1 Subtype C Tat, Nef and Reverse Transcriptase andInvestigation of Antibody Responses to these proteins inHIV-1 Infected Individuals as well as Macaques Vaccinatedwith SAAVI DNA-C/C2 and SAAV
… as antigens to investigate the prevalence of HIV-1 antibodies in sera of HIV-1 infected people. There was no reactivity in any of the 20 negative control sera in the Western blot assay. Analysis of 481 sera from HIV-1 infected individuals showed that the majority of serum samples had …
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The impact of neutralizing antibody and ADCC responses on HIV-1 envelope evolution in early infection
The development of an effective HIV-1 vaccine remains a global priority. Neutralizing antibodies (nAbs), which block infection by cell-free virus, are likely to be an important response for vaccines to elicit. However, evidence from the RV144 vaccine trial and non-human primate vaccine studies …