Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"HIV-1 transmission"”.
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Mucosal HIV-1 Transmission in Humanized Mice
HIV-1 infects ~6,800 people each and every day, transmitting predominantly through unprotected sexual contact. On a global scale, vaginal transmission now accounts for more than half of newly acquired HIV-1 infections. In developed countries intrarectal infection represents a major form of HIV-1 …
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Understanding risk factors for HIV-1 infectiousness and transmission:prospective studies in HIV-1 serodiscordant couples
… and biologic factors associated with increased HIV-1 infectiousness among heterosexual HIV-1 serodiscordant couples. The specific aims include 1) evaluating whether specific characteristics of HIV-1 serodiscordant couples could be used to defined a higher-risk subgroup for targeted prevention …
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Antiretroviral Treatment as Prevention in African HIV-1 Serodiscordant Couples: Understanding the Challenges and Opportunities
… and biologic and behavioral factors related to HIV-1 transmission risk in stable heterosexual HIV-1 serodiscordant African couples. ART is recommended for all HIV-1 infected persons, regardless of CD4 count, to reduce HIV-1 related morbidity, mortality and risk of transmission to uninfected …
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Profiling the neurovascular cell interactions in alcohol exposure and HIV-1 infection
… associated acquired immunodeficiency syndrome or HIV/AIDS in the brain, known as the NeuroAIDS. The mechanisms of this accelerated progression are still poorly understood. The purpose of my thesis is to review the parameters contributing to the co-morbid effects of alcohol in the progression of …
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Interactions of human immunodeficiency virus type 1 with mucosal epithelial surfaces and Candida albicans
Despite the magnitude of the HIV pandemic, the events involved in the initial HIV-1 entry into the body are not yet fully understood. Although the principle mode of HIV-1 transmission is through mucosal surfaces, the oral epithelium appears to be less susceptible to HIV-1 infection than vaginal …
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The Role of Mucosal Epithelial Cells In Hiv-1 Infection
… route of human immunodeficiency virus type 1 (HIV-1) transmission is infection across the vaginal mucosa. Epithelial cells, which form the primary barrier of protection against pathogens, are the first cell type at these mucosal tissues to encounter the virus but their role in HIV infection has …
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Gene expression patterns of the female genital tract and immunomodulation by Lactobacillus species
… genital tract (FGT) is associated with increased HIV-1 viral replication, HIV-1 transmission and HIV-1 acquisition. The optimal commensal Lactobacillus bacterial species is associated with reduced inflammation in the FGT and dampened immune responses to non-optimal bacteria in vitro. Using a …
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The Dynamic Interplay Between Lentiviral Vif and Human APOBEC3 Proteins
… cytosine deaminases are capable of inhibiting HIV-1 replication by deaminating viral cDNA cytosines and interfering with reverse transcription. HIV-1 counteracts restriction with its Vif protein, which nucleates a ubiquitin ligase complex that directly binds A3 enzymes and targets them for …
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HIV neutralization through use of antibodies and pharmacokinetics of topical applications
The Human Immunodeficiency Virus Type 1 (HIV-1), a sexually transmitted retrovirus that causes the Acquired Immunodeficiency Syndrome (AIDS), infects over two million people a year. Several methods introduced to prevent HIV-1 transmission, such as condoms, circumcision and antiretroviral drugs, …
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Male genital tract versus blood HIV-1 compartmentalization and selection: the first step of the transmission bottleneck?
Introduction Sexual transmission of HIV-1 accounts for more than 80% of all the transmissions globally. After transmission, approximately 80% of the newly disseminated infections can be traced to a single variant, which comes from the minor HIV-1 population within the transmitting donor. This has …