Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"HIV-1 restriction"”.
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APOBEC3 Transcriptional Regulation and HIV-1 Restriction in T Lymphocytes
Human immunodeficiency virus type-1 (HIV-1), the etiologic agent of acquired immunodeficiency syndrome (AIDS), has caused one of the most widespread and devastating pandemics in human history, and continues to persist as a substantial burden on global healthcare, social and economic systems, …
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Structural studies of the deaminase domain of the human HIV-1 restriction protein APOBEC3G
… about 33.4 million people were living with the HIV virus, with a 2.7 million increase each year. HIV can lead to AIDS, which is a set of symptoms and infections resulting from the damage to the human immune system. However, due to the rapid mutability and productivity of the HIV, identifying …
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The Role of Linker 2 (L2) Region in RhTRIM5α Assembly and HIV-1 Restriction
<p>The cellular restriction factor TRIM5alpha inhibits infection by numerous retroviruses in a species specific manner. TRIM5alpha protein from rhesus macaques (rhTRIM5alpha) and a related protein TRIM-Cyp from Owl monkeys restrict infection by HIV-1 while human TRIM5α (huTRIM5alpha) …
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Structural Investigations of HIV-1 Restriction: Roles of Autophagy in TRIM5α and HIV-1 Capsid in Complex with a Novel Inhibitor
Human Immunodeficiency Virus type-1, HIV-1, is the primary etiological agent of Acquired Immune Deficiency Syndrome, AIDS, a global pandemic with 1.7 million newly infected persons in 2019 alone. There is no cure to infection, and disease progression can only be prevented by a daily antiretroviral …
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Optimized Microbial Recombinant Production of HIV-1 Anti-Envelope Antibody Fragments with Applications to Single Particle Tracking of Virus Assembly
… of the human immunodeficiency virus type 1 (HIV-1) envelope (Env) protein during HIV viral assembly. There remains insufficient knowledge about the molecular dynamics and interactions of HIV-1 Env protein with its counterpart, Gag, on the inner host cell surface during assembly of a mature …
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The Dynamic Interplay Between Lentiviral Vif and Human APOBEC3 Proteins
… cytosine deaminases are capable of inhibiting HIV-1 replication by deaminating viral cDNA cytosines and interfering with reverse transcription. HIV-1 counteracts restriction with its Vif protein, which nucleates a ubiquitin ligase complex that directly binds A3 enzymes and targets them for …
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Mechanism and Evolutionary Origins of HIV-1 Virion Entrapment by Tetherin
<p>The cellular restriction factor, tetherin, prevents HIV-1 and other enveloped virus particles from being disseminated into the extracellular milieu by infiltrating their envelopes and by physically crosslinking them to the cell surface. However, the mechanisms underlying virion retention have …