Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"HIV-1 inhibitors"”.
-
Characterizing interactions between the cellular HIV-1 integration cofactor, LEDGF/p75 with chromatin and HIV-1 integrase
Continuous emergence of HIV-1 phenotypes resistant to currently available therapies requires the need for development of new drugs with novel targets to prevent HIV-1 replication. Integration is an essential step in the life cycle of HIV-1 allowing for the stable integration of the viral genome …
-
DESIGN, SYNTHESIS, AND OPTIMIZATION OF SMALL-MOLECULE CD4 MIMETICS AS HIV-1 ENTRY INHIBITORS AND SYNTHETIC EFFORTS TOWARD THE TOTAL SYNTHESIS OF NAHUOIC ACID Cii
… challenge of human immunodeficiency virus (HIV-1) eradication is driven in part by the virus’s capacity to evade immune recognition through conformational masking of its envelope glycoprotein (Env). Small-molecule CD4 mimetic compounds (CD4mcs) represent a promising strategy that blocks …
-
Exploring the Early Events in the HIV-1 Life Cycle: From Post-Entry Restriction to Nuclear Import
… cycle of the human immunodeficiency virus (HIV) determine the virus' ability to sustain a persistent infection in susceptible host species. However, many of the molecular machinations through which the virus progresses during its earliest moments in the cell's interior remain enigmatic. …