Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 108 for “"HIV-1 infection"”.
-
Dynamics of HIV-1 Infection and Therapy In Vivo
<p>Human immunodeficiency virus type 1 (HIV-1) is the causative agent of acquired immune deficiency syndrome (AIDS), a disease responsible for extensive morbidity and mortality worldwide. Despite more than thirty years of research since the discovery of HIV-1, no cure or vaccine yet exists. HIV-1 …
-
Regulation of cellular glucose metabolism by HIV-1 infection
… host cells. Human immunodeficiency virus type 1 (HIV-1) causes acquired immune deficiency syndrome, and it uniquely infects both activated CD4+ T cells and terminally differentiated macrophages during the course of HIV-1 pathogenesis. While HIV-1 infection of CD4+ T cells induces G2 arrest and …
-
Anomalies of GABAergic system associated with HIV-1 infection
Human immunodeficiency virus-1 (HIV) infection of the central nervous system results in cognitive and behavioral dysfunctions diagnosed as HIV-associated dementia. Findings of lowered concentrations of γ-Aminobutyric acid (GABA) synthesizing enzymes in brains of HIV-infected patients suggest …
-
Ultrastructural analysis of HIV-1 infection in human cells
Das Humane Immundefizienz-Virus (HIV) ist der Auslöser des erworbenen Immundefizienz-Syndroms (acquired immune deficiency syndrome, AIDS). HIVInfektion, weltweit eine der problematischsten Infektionskrankheiten, betrifft etwa 40 Millionen Menschen und tötet schätzungsweise 3 Millionen Menschen …
-
Immunology and virology of HIV-1 infection in Cameroon
… the widespread existence of highly divergent HIV lineages in Cameroon. While the genetic complexity of the Cameroonian HIV-1 epidemic has potentially serious implications for the design of biomedical interventions, detailed analyses of divergent Cameroonian HIV-1 group M lineages could be …
-
The Role of Mucosal Epithelial Cells In Hiv-1 Infection
… route of human immunodeficiency virus type 1 (HIV-1) transmission is infection across the vaginal mucosa. Epithelial cells, which form the primary barrier of protection against pathogens, are the first cell type at these mucosal tissues to encounter the virus but their role in HIV infection has …
-
Neuropsychiatric complications of efavirenz in children with HIV-1 infection
… to poor longterm neurocognitive outcomes in HIV-infected children. Genetically slow metabolizers are at risk of neurotoxicity. Prospective studies comparing efavirenz-treated and efavirenz-naïve children are needed.
-
Developing improved challenge viruses for macaque models of HIV-1 infection
Infection of macaques with SIV/HIV chimeric viruses (SHIVs) is often used as a model of HIV-1 infection for pre-clinical vaccine studies. Although SHIV infection of macaques serves as the gatekeeper of promising vaccine candidates, it is limited by the fact there are a very small number of SHIVs …
-
Modeling HIV-1 Infection and Immune Responses Under Drugs of Abuse
The frequent use of drugs of abuse among HIV infected individuals is a major concern. Drugs of abuse, such as opiates, have been widely associated with enhanc ing HIV replication, accelerating disease progression, and diminishing host-immune responses. Moreover, opiates such as morphine have also …
-
The role of bacterial vaginosis-associated sialidase on HIV-1 infection
… (BV) are at a higher risk of being infected by HIV-1. One possible reason is that bacterial vaginosis-associated bacteria (BVAB) release sialidases which alter either the virus and host cells directly or the viscosity of the female vaginal tract (FGT) mucosal barrier, increasing the likelihood …
-
Profiling the neurovascular cell interactions in alcohol exposure and HIV-1 infection
… associated acquired immunodeficiency syndrome or HIV/AIDS in the brain, known as the NeuroAIDS. The mechanisms of this accelerated progression are still poorly understood. The purpose of my thesis is to review the parameters contributing to the co-morbid effects of alcohol in the progression of …
-
Genetic diversity and population structure within Botswana: association with HIV-1 infection
Southern Africa is disproportionately affected by HIV-1, with Botswana being among the most affected countries. The interindividual heterogeneity in susceptibility or resistance to HIV-1 and progression upon infection is attributable to, among other factors, host genetic variation. Characterisation …
-
Gene Expression Changes in Immune Cells During Human Immunodeficiency Virus 1 (HIV-1) Infection
Human immunodeficiency virus infection is a chronic condition causing significant changes in the immune system, which are reflected in the altered gene expression patterns of the immune cells. By studying these patterns through gene expression profiling it is possible to describe not only the …
-
Modeling HIV-1 Infection in the Brain: The Effect of the Blood-Brain Barrier
… antiretroviral therapy (ART), the development of HIV associated neurocognitive disorders (HAND) remains a major concern among HIV infected patients. As many ART drugs may fail to penetrate the blood-brain barrier (BBB), the long-term presence of viral RNA in the brain is considered to be …
-
Molecular Mechanisms of HIV-1 Infection: Viral and Host Determinants in Transmission and Pathogenesis
HIV-1 vertical transmission is the predominant cause of AIDS in children. In addition, HIV-1 infected infants have a higher viral load and progress to AIDS more rapidly than infected adults. However, the molecular mechanisms of HIV-1 vertical transmission and pathogenesis are not known. Work …
-
HIV-1 INFECTION OF NEURAL STEM CELLS RESULTS IN COGNITIVE DEFICITS THROUGH ADULT NEUROGENIC MODULATION
… decreased the mortality rate in patients with HIV-1 infection and subsequent opportunistic infections, the co-morbidities continue to rise. Some of these co-morbidities include cardiomyopathies, metabolic dysfunction, accelerated aging, and most notably, neurocognitive deficits. HIV-1 …
-
Screening for novel compounds produced by Actinobacteria and Gardnerella vaginalis that impact HIV-1 infection
HIV-1 infection continues to impact the lives of millions, with the most vulnerable being women living in Sub-Saharan Africa. Variation in the outcome of antiretroviral (ARV) and preexposure prophylaxis (PrEP) clinical trials is most likely multifactorial which could include Bacterial Vaginosis …
-
Mathematical models of coreceptor usage and a dendritic cell-based vaccine during HIV-1 infection
While most of Europe is affected by HIV-1 subtype B, sub-Saharan African is dominated by HIV-1 subtype C. Due to costs, most vaccine development is carried out Europe rather than sub-Saharan countries. However since the mechanisms of disease progression in HIV-1 subtype B may be different from …
-
Retroviral envelope glycoproteins: mediators of neuropathology in nervous system development and neurodegeneration in HIV-1 infection
… have neuropathology identified at autopsy. HIV-1, the causative organism of AIDS, produces neuronal death as a primary viral effect in many AIDS cases, and it does so even though the virus does not infect neurons. The search for the pathomechanisms by which HIV-1 causes neurologic disease …
Page 1 of 6