Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"HIV-1 Integrase"”.
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Design and synthesis of HIV-1 integrase inhibitors
In recent years, HIV-1 integrase (IN) has emerged as an attractive target for the treatment of human immunodeficiency virus type 1 (HIV-1), the causative pathogen of acquired immuno-deficiency syndrome (AIDS). Several classes of IN inhibitors are known but many of these compounds are toxic, do not …
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Synthesis and Computational Studies on Hiv-1 Integrase Inhibitors
HIV-1 integrase (IN) is essential for viral replication and offers a promising target for the development of anti-retroviral drugs. Two decades of extensive research has lead to the recent approval of raltegravir as the first IN inhibitor. Advancement of drug candidate elvitegravir, which is …
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Characterizing interactions between the cellular HIV-1 integration cofactor, LEDGF/p75 with chromatin and HIV-1 integrase
Continuous emergence of HIV-1 phenotypes resistant to currently available therapies requires the need for development of new drugs with novel targets to prevent HIV-1 replication. Integration is an essential step in the life cycle of HIV-1 allowing for the stable integration of the viral genome …
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Dissecting the Contribution of the Carboxyl-Terminal Domain and Tail of HIV-1 Integrase to Viral Dynamics and Enzymatic Function
<p>The Human Immunodeficiency Virus Type-1 (HIV-1) is the causative agent of the Acquired Immune Deficiency Syndrome (AIDS). Combination antiviral therapy has proven to be particularly effective at suppressing viral replication, yet complete eradication of the virus from an infected individual …
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Exploring the Early Events in the HIV-1 Life Cycle: From Post-Entry Restriction to Nuclear Import
… cycle of the human immunodeficiency virus (HIV) determine the virus' ability to sustain a persistent infection in susceptible host species. However, many of the molecular machinations through which the virus progresses during its earliest moments in the cell's interior remain enigmatic. …
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Biochemical, Structural, And Drug Design Studies Of Multi-Drug Resistant Hiv-1 Therapeutic Targets
… mechanisms that lead to multi-drug resistance to HIV-1 protease and integrase inhibitors. </p> <p>Proper proteolytic processing of the HIV-1 Gag/Pol polyprotein is required for HIV infection and viral replication. This feature has made HIV-1 protease an attractive target for antiretroviral drug …
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Biochemical and Functional characterization of the LEDGF/p75-MeCP2 Interaction in Tumor Cells
… syndrome (AIDS) since it interacts with HIV-1 integrase to facilitate the integration and replication of the HIV virus in human cells. In addition, LEDGF/p75 has been shown to interact with MLL (mixed lineage leukemia)/menin transcription complex in leukemia cells to facilitate the …
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Characterization of the mechanism of action of new HIV-1 reverse transcriptase-associated ribonuclease H inhibitors
HIV-1 the Reverse Transcriptase (RT), the most renowned retroviral specific enzyme, was the first anti-HIV target to be exploited, as. HIV-1 RT combines two functions essential for viral replication: DNA polymerase, synthesis DNA either in a RNA dependent (RDDP) or DNA dependent (DDDP) manner, and …