Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 537 for “"HIV-1"”.
-
Tobacco/HIV-1-Induced Myeloid Cell-Derived Extracellular Vesicles in HIV-1 Pathogenesis
… which is highly prevalent in people living with HIV/AIDS, has been shown to exacerbate HIV-1 replication, in part via cytochrome P450 (CYP)-induced oxidative stress. CYP enzymes metabolize cigarette smoke condensate (CSC), causing oxidative stress and cytotoxicity. Our previous studies have …
-
HIV-1 evolution, disease progression and molecular epidemiology of HIV-1 single and HIV-1 and HIV-2 dual-infected individuals in Guinea-Bissau
… related human lentiviruses known today, HIV-1 (which is pandemic) and HIV-2 (which mainly is confined to West Africa), are the causative agents of AIDS. Progressive immune dysfunction and AIDS develop in most cases of untreated HIV-1 infection, but only in approximately 25-30% of HIV-2 …
-
Understanding risk factors for HIV-1 infectiousness and transmission:prospective studies in HIV-1 serodiscordant couples
… and biologic factors associated with increased HIV-1 infectiousness among heterosexual HIV-1 serodiscordant couples. The specific aims include 1) evaluating whether specific characteristics of HIV-1 serodiscordant couples could be used to defined a higher-risk subgroup for targeted prevention …
-
Characterization of HIV-1 Rev mutants
The HIV Rev protein has the ability to bind tubulin heterodimers and depolymerize microtubules (MTs) in vitro (Watts et al. 2000). These interactions may account for MT defects observed in HIV infected cells or cells that over-express Rev. Watts et al. hypothesized Rev interacts with MTs by a …
-
Intrahost evolution of HIV-1 phenotypes
HIV-1 evolves constantly within an infected individual, due to its mutation-prone viral enzyme, high viral turnover and pressure from the host immune system. Therefore, viruses isolated at different time points from the same individual are never exactly the same and, accordingly, rarely function …
-
Characterizing interactions between the cellular HIV-1 integration cofactor, LEDGF/p75 with chromatin and HIV-1 integrase
Continuous emergence of HIV-1 phenotypes resistant to currently available therapies requires the need for development of new drugs with novel targets to prevent HIV-1 replication. Integration is an essential step in the life cycle of HIV-1 allowing for the stable integration of the viral genome …
-
Elucidating the mechanisms and dynamics of drug-mediated inhibition and latency reversal in HIV-1 (HIV-1)
… The Human Immunodeficiency Virus Type-1 (HIV-1) is the etiological agent of Acquired Immunodeficiency Syndrome, a disease that causes the host to succumb to secondary infections. There is currently no cure for HIV-1 infection, but Highly Active Anti-Retroviral Therapy (HAART) can bring the …
-
HIV-1 Vpu Oligomerization in Membrane Mimetics
HIV-1 is a pandemic virus that has a continuing impact on human society. As treatments for HIV-1 infection improve, new targets for viral inhibition have provided a means to reduce a once-lethal infection into a manageable chronic condition. Among other proteins, HIV-1 encodes the Vpu accessory …
-
Dynamics of the HIV-1 Latent Reservoir
Human immunodeficiency virus type 1 (HIV) has caused more than 35 million deaths world-wide and contributes significantly to the global burden of disease. Currently, the only effective treatment to suppress viral replication and prevent HIV transmission is combination antiretroviral therapy (ART), …
-
Mucosal HIV-1 Transmission in Humanized Mice
HIV-1 infects ~6,800 people each and every day, transmitting predominantly through unprotected sexual contact. On a global scale, vaginal transmission now accounts for more than half of newly acquired HIV-1 infections. In developed countries intrarectal infection represents a major form of HIV-1 …
-
The Intracellular Kinetics of HIV-1 Replication
The rate of HIV-1 replication has an impact on the viral loads patients have and the time it takes for an infection to progress to AIDS. This replication rate is defined partly by the time it takes an infected cell to begin producing new infectious virus, and this, in turn, is defined by the time …
-
HIV-1 Immune Escape and Neutralizing Antibodies : Solid Phase Proteoliposomes Containing HIV-1 Envelope Glycoproteins as Antigens and Immunogens and HIV-1 Core Envelope Glycoproteins Deficient in T-Helper Epitopes
The HIV-1 envelope glycoproteins gp120 and gp41 mediate binding and fusion of the virus to target cells. The envelope glycoproteins are exposed on the surface of the virus as trimeric spikes and are the major targets for neutralizing antibodies. The design of envelope glycoprotein-based subunit …
-
Evaluating individuals with extreme phenotypes of HIV-1 contributes towards better healthcare management of all HIV-1 positive individuals
Human Immunodeficiency Virus (HIV)-1 disease progression is variable within patients where some remain asymptomatic for long periods (elite controllers (EC)) while others rapidly progress to disease (rapid progressors (RP)), representing the ‘extreme phenotypes’. There is substantial heterogeneity …
-
Proteomic Analyses of HIV-1 Infected T-cells and the Functional Characterization of Cyclophilin B During HIV-1 Infection
The human immunodeficiency virus type 1 (HIV-1) lifecycle is complex and the virus interacts with many host cellular proteins for productive replication. Mass spectrometry analysis is a powerful tool to identify cellular proteins important for HIV replication and pathogenesis. Prior proteomic …
-
Hiv-1 Rna Dimerization At Single Molecule Level
… hairpin-loop motif on the 5' UTR of the HIV-1 genome. It plays an important role in genome dimerization through formation of a "kissing complex" intermediate between two homologous DIS sequences. This bimolecular kissing complex ultimately leads to the formation of an extended RNA duplex. …
-
Innate and humoral immune responses to HIV-1
… cellular and humoral immune responses to HIV-1 infection and designed HIV immunogens are imperative to the development of an effective anti-HIV vaccine. In this thesis we investigate aspects of both the cellular innate and adaptive humoral arms of the immune system in response to HIV-1 …
-
Toxicities associated with antiretroviral treatment of HIV-1
… treatment (ART) in human immunodeficiency virus (HIV), the associated toxicities are complex to manage and compromise treatment benefits. Prevention and treatment of chronic toxicities such as cardiovascular disease (CVD), metabolic disorders, lipodystrophy, and osteoporosis are essential to …
-
The HIV-1 entry inhibition capabilities of Isoflavones
The availability of treatment for HIV infection has resulted in a drastic increase in the life expectancy of infected individuals. However, the current therapeutics fall short in many areas. A considerable 60% of treated individuals will show minor cognitive disorders due to infection, immune …
-
Design and synthesis of HIV-1 integrase inhibitors
In recent years, HIV-1 integrase (IN) has emerged as an attractive target for the treatment of human immunodeficiency virus type 1 (HIV-1), the causative pathogen of acquired immuno-deficiency syndrome (AIDS). Several classes of IN inhibitors are known but many of these compounds are toxic, do not …
Page 1 of 27