Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"HIV viral load"”.
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Role of delay differential equations in modelling low level HIV viral load
Over the past 30 years, HIV has infected over 60 million people, with almost half succumbing to AIDS-related illnesses.While antiretroviral therapy, used to significantly reduce within-host HIV replication, was available within 10 years of the discovery of HIV/AIDS, it is only within the last 10 …
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HIV viral load monitoring in HIV-infected pregnant women established on antiretroviral therapy in Cape Town, South Africa
Background: Antiretroviral therapy (ART) services have expanded over the past decade, providing treatment to over 15 million people globally. It is imperative that this scale-up of ART provision be accompanied by optimal treatment response monitoring strategies to timely and accurately detect …
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Prevalence, predictors, and association of probable non-specific psychological distress and depression with HIV viral load among postpartum women in Cape Town, South Africa
… are prevalent among postpartum women living with HIV and may affect engagement in HIV care. We examined the prevalence and predictors of probable non-specific psychological distress and depressive symptoms and their association with elevated viral load (VL) in Cape Town, South Africa. Methods: …
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How accurately do routinely reported HIV viral load suppression proportions reflect progress towards the 90-90-90 target in the population on ART in Khayelitsha, South Africa?
… In 2016, Khayelitsha reported almost 89% viral load (VL) suppression but less than 56% completion on routine quarterly reports, casting doubt on the validity of reported suppression. Objectives: To assess the validity of reported VL suppression as a measure of progress towards the 90-90-90 …
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Impact of Unintended pregnancy on HIV viral load outcomes among postpartum women living with HIV in Cape Town, South Africa: clues from postpartum adherence clubs for antiretroviral therapy trial
Introduction: Postpartum women living with HIV (WLWHIV) on antiretroviral therapy (ART) are at high risk of viraemia. We examined the association between unintended pregnancy and HIV viral load (VL) at 24 months postpartum in Cape Town, South Africa. Methods: Data are from a randomised trial that …
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The prognostic value of HIV viral load in predicting viraemic outcomes of post-partum women on antiretroviral therapy: a secondary analysis of two randomised controlled trials from Gugulethu, Cape Town
Background: Vertical transmission of HIV continues to be a significant health concern for HIV-infected women in pregnancy and postpartum, especially in Southern Africa, despite decreasing rates of infection. While better access to effective and acceptable antiretroviral therapy (ART) regimens has …
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Classification of HIV virological failure using whole blood versus plasma viral load
Introduction: HIV viral load testing is the preferred monitoring approach for HIV infected patients on combination antiretroviral therapy (cART) as it is more sensitive than CD4 count and clinical monitoring. In resource limited settings, timely plasma separation and transportation to testing …
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The predictors and patterns of alcohol use in HIV positive women during their postpartum period, and how these impact viral load.
Introduction Although alcohol use among HIV-positive pregnant women in South Africa has been extensively researched, few studies have attempted to understand the longitudinal patterns and predictors of alcohol use when HIV-positive status intersects with the postpartum period. We examined the …
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Clinical Implications of HIV-1, HSV-2 Co-infection and Opportunities for Intervention
HSV-2 may have adverse consequences in HIV. I evaluated the impact of HSV-2 co-infection on (highly active antiretroviral therapy)-untreated HIV infection in a systematic review of observational studies (study 1) and a retrospective cohort (study 2). I further evaluated whether HSV reactivation …
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Development of spectroscopic smartphone biosensors for point-of-care applications
… capability can be leveraged to measure HIV viral load using a novel biosensor, designed specifically developed for a smartphone based platform for point of care applications.
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A formative and outcome evaluation of a community based antiretroviral therapy adherence programme : the case of Sizophila, Cape Town, South Africa
… Sizophila programme, a community based antiretroviral therapy (ART) programme. The programme is administered by the Desmond Tutu HIV Foundation, a non-profit organization. The aim of the programme is to enhance ART health outcomes and promote individual wellbeing among people accessing human …
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Travel and adherence to antiretroviral therapy among postpartum women living with HIV in South Africa: a cross-sectional study
… Africa, women are disproportionately affected by HIV. Sustained adherence to lifelong antiretroviral therapy (ART) is needed to ensure their own health and prevent transmission of HIV to their partners and their children. However, non-adherence to ART remains a substantial challenge with many …
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Construction and evaluation of three candidate vaccines expressing HIV-1 subtype-C mosaic Gag
Of the 35 million people living with HIV-1 globally, approximately 71.4% are in the resource-limited sub-Saharan Africa. The immense sequence diversity of HIV-1, even within subtypes, makes it challenging to develop effective vaccines that target a wide range of HIV subtypes. Mosaic immunogens have …
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HIV-positive African women’s engagement with HIV care in the UK during and after pregnancy
Approximately 1400 HIV-positive women are known to become pregnant in the UK each year, the overwhelming majority being from Sub-Saharan Africa. The overall question I pose in this thesis is: how do African women living with HIV in the UK engage with HIV services and interventions during and after …
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HIV positive patients in intensive care - a retrospective chart review
… of intensive care unit (ICU) admission of HIV - infected patients in resource - poor settings like Sub - Saharan Africa are unknown. Methods: We reviewed case records of HIV - infected patients admitted to the medical and surgical ICUs at Groote Schuur Hospital, South Africa from 1 January …
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Look and Leep: How are we doing? An audit of GSH colposcopy clinic from 1 January 2017 to 31 December 2021
… and the odds of overtreatment as well as between HIV negative women, when compared to HIV positive women on treatment, and the odds of overtreatment. No statistically significant association was found between smoking status, HIV viral load, CD4 count or parity. Conclusion: The overtreatment rate …
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Burkitt and Burkitt-like lymphoma/leukaemia at Groote Schuur Hospital from 2005 to 2014: a retrospective review
… global burden of human immunodeficiency virus (HIV). The HIV seropositive population is at increased risk of developing non-Hodgkin lymphoma, particularly high grade aggressive subtypes such as Burkitt- and Burkittlike lymphoma (also known as B-cell lymphoma, unclassifiable, with features …
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Microscale biosensors for HIV detection and viral load determination
The HIV/AIDS pandemic has killed 39 million people worldwide, and nearly as many people are living with HIV infection today. The global response to this disease has come a long way since the emergence of HIV in the early 1980s, including more than 64 billion USD in international spending between …
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The Impact of GB Virus C co-infection on Mother to Child transmission of Human Immunodeficiency Virus
… that can inhibit human immunodeficiency virus (HIV) replication in vitro. Persistent coinfection with GBV-C has been associated with improved survival among HIV-infected adults while loss of GBV-C viremia has been associated with poor survival. If GBV-C does inhibit HIV replication, it is …
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Cardiometabolic Diseases and HIV Infection: The Impact of Highly Active Antiretroviral Therapy
… (CVD) events in a retrospective cohort of HIV-infected and non-HIV-infected individuals. And to evaluate the association of these outcomes with exposure to highly active antiretroviral therapy (HAART) medications i.e. protease inhibitors (PIs), non-nucleoside reverse transcriptase …
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