Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"HIV subtypes"”.
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Evolution of viral populations in individuals infected with single and multiple HIV subtypes : a study of HIV-1 dual infection in a high risk cohort of female bar workers from Tanzania
The Human Immunodeficiency virus (HIV) is characterized by high replication rate and high levels of diversity resulting in numerous quasispecies that form a 'swarm' in the infected individual. HIV diversification is driven by selection pressure exerted by the host. The role of high viral diversity …
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Construction and evaluation of three candidate vaccines expressing HIV-1 subtype-C mosaic Gag
Of the 35 million people living with HIV-1 globally, approximately 71.4% are in the resource-limited sub-Saharan Africa. The immense sequence diversity of HIV-1, even within subtypes, makes it challenging to develop effective vaccines that target a wide range of HIV subtypes. Mosaic immunogens have …
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Mathematical modelling of emerging and re-emerging infectious diseases in human and animal populations
… analysis of the competition model between two HIV subtypes in presence of vaccination and cross-immunity proposed by Porco and Blower (1998). We find the sharp conditions under which vaccination leads to the coexistence of the strains and using arguments from bifurcation theory, draw …
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Characterisation of the Ugandan HIV epidemic with full-length genome sequence data from 1986 to 2016
Presented here are two large Ugandan HIV genome datasets, one from the modern period (by the MRC/UVRI & LSHTM group and PANGEA), and another generated from stored 1986 serum samples using target-capture next generation sequencing. Uganda uniquely has two HIV subtypes at similar proportions, and …