Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"HIV strains"”.
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Factors influencing adherence to Antiretroviral Therapy at a General Hospital in Mombasa, Kenya
… Africa is home to two thirds of the 33 million HIV infected individuals worldwide. In 2007 there were an estimated 1.5 million Kenyans infected with HIV, and 166 000 new infections in 2008. The introduction of antiretroviral therapy [ART] brought new hope to HIV patients. It has transformed a …
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Factors associated with adherence to anti-retroviral therapy in Katima Mulilo hospital, Namibia
… of the countries in the world most affected by HIV/AIDS with the national prevalence of 18.8% in 2010. In 2010, it was reported that an estimated 180,000 Namibians were living with HIV/AIDS; of which 95,000 adult women, 69,000 adult men and 16,000 children. An estimated 6,700 deaths was recorded …
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A statistical mechanics approach to vaccination against HIV
… by one antigen. A highly mutable virus like HIV evades recognition by these strain-specific antibodies via the emergence of new mutant strains within the patient. In some chronically infected patients, antibodies that can bind diverse antigens and thus protect against many HIV strains arise …
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Neutralizing antibody responses in HIV dual infection: lessons for vaccine design
The development of a safe, effective prophylactic HIV vaccine remains a major global health priority. Stabilized, soluble trimers that mimic the native functional HIV trimer have been developed that elicit strain-specific neutralizing HIV antibodies in animal models, and are currently being …
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Conformational engineering of human chemokine receptors and HIV-1 Env using deep mutational scanning
… CCR5, which are well-studied co-receptors for HIV-1 infection. Libraries of both receptors containing nearly all ~7,000 single amino acid substitutions were selected in tissue culture for surface expression, binding to conformation-specific antibodies, binding to a chemokine, and binding to the …
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Investigating the executive functioning and patterns of adherence to antiretroviral therapy among adolescents living with HIV in South Africa
… with the Human Immunodeficiency Virus (HIV) and the reported predilection for frontal circuitries and deep white matter, one might expect that executive dysfunction forms part of the neurocognitive profile of people living with HIV. However, such deficits have mainly been reported for …
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The battleground of two Infections and a cancer: Human Papilloma Virus, premalignant lesions of the cervix and their interaction with Human Immunodeficiency Virus in southwestern Nigeria
Background: The highest numbers of HIV-infected women are in sub- Saharan Africa, where the natural progression of HIV disease in the absence of treatment results in death before the onset of invasive cervical cancer. With improved access to treatment, several studies outside West Africa …
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Data-driven strategies for vaccine design
… 1. Developing an antibody vaccine against HIV, an example of a highly mutable pathogen; and 2. Understanding how the many immune components work collectively to effect a systemic immune response, such as to vaccines. In HIV-infected individuals, antibodies produced by the immune system bind …
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Methods in Total Synthesis: Development of a 2nd-Generation Synthesis of CJF-III-288, and Synthetic Efforts Towards the Total Synthesis of Sequoiamonascin A
… SYNTHESIS OF CJF-III-288, A HIGHLY POTENT HIV-1 ENTRY INHIBITOR FOR IN-VIVO STUDIESAs of 2023, 39.9 million people worldwide were living with the human immunodeficiency virus (HIV). The current state of the art for treatment of HIV is Highly Active Antiretroviral Therapy (HAART), which …
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Development of SNAP-tag-based fusion proteins targeting HIV-1 viral reservoirs
Background Globally, the HIV/AIDS epidemic has cost over 35 million lives and approximately a further 37 million people are currently infected with HIV. In South Africa alone, more than 7 million people are HIV positive. Since the initiation of combination antiretroviral therapy (cART), viral …
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Evaluating the Impact of Antibody Epitope and Function on HIV-1 Vertical Transmission
… strategies over the past several decades, the HIV/AIDS pandemic continues to pose a significant threat to public health. Nearly 40 million people are estimated to be living with HIV, with 1.5 million new infections in 2021 alone. An effective HIV vaccine would help to reduce the global burden …