Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"HIV reservoir"”.
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INFLAMMATORY AND T-CELL HOMEOSTASIS PARAMETERS IN DUAL AND TRIPLE COMBINATION ANTIRETROVIRAL THERAPY (CART) FOR HIV INFECTION
Primary HIV infection (PHI) plays a pivotal role in establishing the viral reservoir, leading to persistent immune activation and inflammation despite combination antiretroviral therapy (cART). While cART has transformed HIV into a manageable chronic condition, it remains unable to eradicate the …
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The impact of heptose phosphates on HIV latency and human immune responses
Use of HIV-specific antiretroviral therapeutic agents (ARTs) achieves total control of viremia and prevents progression of HIV to AIDS, but they are not a cure. Shock-and-kill therapy aims to use HIV latency reversal agents to promote clearance of HIV infected CD4 T-cells that make up the HIV …
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Human Papillomavirus and Anorectal Immunology in HIV-positive Men who have Sex with Men
… (HPV) infection is prevalent among HIV-positive men who have sex with men (MSM) and can lead to the development of anal intraepithelial neoplasia (AIN) before possibly progressing to anal cancer. However, very little is known about mucosal immune changes that occur as a consequence …
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A Novel Role for and Potential Therapeutic Targeting of Heme Oxygenase-1 in HIV Neuropathogenesis
HIV-associated neurocognitive disorders (HAND) affect up to 50% of HIV-infected adults despite potent viral suppression with antiretroviral therapy (ART) and are associated with persistent neuronal damage, monocyte/macrophage activation, chronic inflammation, and oxidative stress. Heme oxygenase-1 …
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SMAC Mimetics Sensitize HIV-Infected Cells to MG1-Mediated Death
The main challenge in finding an HIV cure is the targeting and elimination of the HIV reservoir of latently infected CD4+ T-cells and persistently infected macrophages. While these cells are phenotypically indistinguishable from their healthy counterparts, they display impairments in their …
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THE ROLE OF CD4+ T MEMORY SUBSETS IN HIV INFECTION: IMMUNE RESPONSE IN PEOPLE WITH HIV AND LATENCY ESTABLISHMENT
… In the context of human immunodeficiency virus (HIV), CD4+ TSCM, serve as target of infection as well as reservoir, sustaining long-lived, self-renewing pools of latently infected cells despite antiretroviral therapy (ART). Thus, TSCM are central to both protective immunity and the persistence of …
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Combating HIV-1 by Targeting Drug Efflux Transporters on the Macrophage Reservoir
<p><strong>Introduction</strong>. HIV-1 eradication has not been achieved so far due to the existence of the cellular reservoir in which the virus can reside and replicate even under antiretroviral drug therapy (ART). Infected macrophages, which represent a long-term viral reservoir have been shown …