Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"HIV entry"”.
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HIV entry : a biophysical and mutational analysis of gp41-mediated membrane fusion and its inhibition
… designed to elucidate the manner in which the HIV-1 envelope protein (Env) initiates infection of host cells, and to develop inhibitors of viral entry. Env comprises two non-covalently attached subunits, gpl20 and gp41, that associate as a trimer on the virion surface. Once gp 120 contacts the …
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A Novel Gene Therapy Approach Based on Secreted Antiviral Proteins for the Control of HIV Replication
HIV entry into target cells requires the interaction of the HIV envelope glycoprotein (Env) with a primary receptor (CD4) and a co-receptor (most commonly CCR5 or CXCR4). Protein-based HIV entry inhibitors are highly effective in protecting cells from infection. However, their clinical application …
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The role of bacterial vaginosis-associated sialidase on HIV-1 infection
… (BV) are at a higher risk of being infected by HIV-1. One possible reason is that bacterial vaginosis-associated bacteria (BVAB) release sialidases which alter either the virus and host cells directly or the viscosity of the female vaginal tract (FGT) mucosal barrier, increasing the likelihood …
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The regulation of CXCR4 and CCR5 expression on human monocytes by Th1 and Th2 cytokines: Functional implications on cell migration and HIV infection.
… chemokine receptor expression on chemotaxis and HIV infection, are poorly understood and constituted the major aim of this investigation. To understand the molecular mechanisms of chemokine receptor down regulation induced by Th1 and Th2 cytokines, the expression of mRNA encoding CXCR4 and CCR5 …
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Dynamic Molecular Mechanisms and Drug Design of Important Therapeutic Targets
… chemokine receptor, in particular, helps promote HIV entry into host cells. Polycystin-1 (PC1) is an atypical GPCR with 11 transmembrane domains. Mutations in the PC1 protein are responsible for the majority cases of a potentially lethal human autosomal dominant polycystic kidney disease (ADPKD). …
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The HIV-1 entry inhibition capabilities of Isoflavones
The availability of treatment for HIV infection has resulted in a drastic increase in the life expectancy of infected individuals. However, the current therapeutics fall short in many areas. A considerable 60% of treated individuals will show minor cognitive disorders due to infection, immune …
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Coordination among proteins, lipids and water in membrane fusion and fission probed by solid-state NMR
For enveloped viruses such as HIV, influenza, and coronaviruses to enter host cells, the viral and cell envelopes must be fused together. Then, to exit the cell, a new virus particle will pinch off a piece of the host cell membrane. The two membranes must be physically separated to release the …
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Structure-based Design of Small Molecule Inhibitors of HIV-1 Entry
HIV infection begins when gp120 envelope protein on the viral surface binds to the CD4 receptor on the host cell. This initial protein-protein interaction starts the rest of the HIV lifecycle of coreceptor binding, fusion and replication. One of the targets of HIV entry inhibitors is the …
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Differential effects of combinations of anti-retrovirals and progestins on gene expression and HIV-1 replication in cells of the female genital tract
Young women in areas of high HIV risk are more vulnerable to new HIV infections compared to men. With the development of programmes using anti-retrovirals (ARVs) to prevent HIV infection, the concurrent use of hormonal contraception and ARVs is likely to increase in young women. Products delivering …
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Studies of G Protein-Coupled Receptor Stability and Dimerization Using Novel Fluorescence and Crosslinking Approaches
… receptor 5 (CCR5), the primary coreceptor for HIV-1 cellular entry, was studied. The assay enabled high-throughput detection of femtomole quantities of CCR5. Thermal denaturation measurements demonstrated that small molecule antagonists substantially stabilize CCR5 and also revealed that the …
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Development of Closomer And MIBG based Nanoformulation: Application to HIV Prevention and Neuroblastoma Therapy
… based nanoformulation for the prevention of HIV/AIDS sexual transmission. Part #2 focuses on the development and characterization of a meta-iodobenzylguadinine (MIBG) based nanoformulation of etoposide (VP-16) intended for the treatment of neuroblastoma. This work is presented in 6 chapters …