Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"HIV drugs"”.
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Synthesis and Characterization of Poly(lactide) Functional Oligomers and Block Copolymers
… of potential core-shell delivery vehicles for HIV drugs. PEO-b-PDLLA block copolymer was used as a polymeric nanocarrier to encapsulate the HIV protease inhibitor, Ritonavir, within magnetite nanoparticles. Well-defined multifunctional polymeric nanoparticles with controlled sizes and size …
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An exploratory study of perceived barriers to antiretroviral therapy adherence amongst adolescents in Omuthiya district, Namibia
… Living with Human Immuno-Deficient Virus (ALHIV) aged 15-19 as well as Six (6) Health Care Workers as key informants. Both were purposively sampled. Data for the study were gathered through in-depth interviews using interview guides as research instrument. The study employed the thematic data …
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Synthesis of New Pullulan Derivatives for Drug Delivery
… We have also prepared ASDs of selected anti-HIV drugs, ritonavir (RTV), efavirenz (EFV) and etravirine (ETR) with the cellulosic derivative carboxymethyl cellulose acetate butyrate (CMCAB). This polymer was efficient in stabilizing RTV and EFV in their amorphous form in the solid phase and …
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Investigating MCE Chemical Library Drugs for Combinational Therapies for Clinical Aspergillus fumigatus isolates
… round –surprisingly 50% of those compounds were HIV drugs, cobicistat, elvitegravir, lopinavir. The remaining three selected compounds are penfluridol, rilapladib, and rolapitant. The combination of itraconazole (ITC), posaconazole (POS), and voriconazole (VRC), with the identified compounds …
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Probing the HIV Reverse-Transcriptase enzyme with novel bifunctional HIV-1 RT inhibitors of the general formula (NRTI)-spacer-(NNRTI)
… inhibitors have prompted the design of double-drugs combining these two entities with the aim of addressing the emergence of resistance as well as searching for synergism between the two drug target sites on HIV reverse transcriptase (RT). The strategy involves combining two different …
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Screening for novel compounds produced by Actinobacteria and Gardnerella vaginalis that impact HIV-1 infection
HIV-1 infection continues to impact the lives of millions, with the most vulnerable being women living in Sub-Saharan Africa. Variation in the outcome of antiretroviral (ARV) and preexposure prophylaxis (PrEP) clinical trials is most likely multifactorial which could include Bacterial Vaginosis …
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Hybrid Cyclic-Linear Cell-Penetrating Peptides Containing Alternative Positive and Hydrophobic Residues as Molecular Transporters
… phosphopeptide (F′-GpYEEI) and anti-HIV drugs (lamivudine (F′-3TC), emtricitabine (F′-FTC), Stavudine (F′-d4T)), where F′ is carboxyfluorescein, were measured in the presence of the peptides in CCRF-CEM and SK-OV-3 cells. Among all peptides, [(RW)<sub>5</sub>K](RW)<sub>5</sub> (10 μM) …
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Amphiphilic Cell-Penetrating Hybrid Cyclic-Linear Peptides as a Drug Delivery System
… (F′-GpYEEI), and fluorescent labeled anti-HIV drugs (F′-FTC and F′-d4T). The results indicated that the presence of positively charged arginine residues on the ring and hydrophobic tryptophan residues in a sequential linear outside the ring was an optimal approach to improve the …
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Stereoselective and Economical Methods for Chemical Synthesis of Essential Medicines
… In this thesis, synthesis of small molecule drugs emtricitabine, lamivudine, bedaquiline, and diazepam was investigated. Stereoselective strategies and cost-of-goods reduction more broadly are described. Lastly, a perspective on reproductive health safety in the chemical laboratory is …
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Challenges faced by health professionals regarding the implementation of HIV/AIDS guidelines at PHC facilities of Vhembe District, South Africa
HIV/AIDS is an overwhelming global pandemic that affects the country’s health-care system. In order to reduce HIV/AIDS morbidity and mortality, the World Health Organization has called on countries to provide earlier access to antiretroviral therapy. In order to comply with the World Health …