Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"HIV drug resistance"”.
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Isothermal Nucleic Acid Assays for the Detection of HIV Drug Resistance and Sickle Cell Disease in Low-Resource Settings
HIV treatment has become more widely available and effective in the past several decades, with major global health initiatives targeted at increasing diagnosis, treatment, and viral suppression. However, as treatment for HIV has become more widely available and effective, HIV drug resistance has …
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Weak signal identification and inference in penalized model selection
… approaches. The method is illustrated for HIV antiretroviral drug susceptibility data to identify genetic mutations associated with HIV drug resistance. We also provide signal's inference method based on the exact distribution of penalized estimator. The finite sample distribution is quite …
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Scalable Tools for High-throughput Viral Sequence Analysis
… performance was benchmarked using two large HIV datasets collected from the Los Alamos HIV Sequence Database and the UK HIV Drug Resistance Database, as well as on simulated data. Finally, I present a computational pipeline named Phlow, for rapid phylodynamic inference of heterochronous …
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Factors associated with different responses to combination antiretroviral therapy in an observational cohort study of HIV-1 infected patients
… into clinical practice for the treatment of HIV in 1995-1996 has led to dramatic reductions in mortality and morbidity. Factors linked to a positive response to therapy include a potent and tolerable regimen, good adherence and low levels of HIV drug resistance. The aims of this thesis were …
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Evaluation of adherence to antiretroviral therapy using efarivenz as a marker
… success (maximum and durable suppression of HIV-1 viral load); non-adherence may lead to the development of HIV drug resistance, which may lead to virologic failure and treatment failure. Therapeutic drug monitoring (TDM) has been reported to be the most efficient method to assess treatment …
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Characterization of and risk factors for HIV-1 resistance mutations following first line antiretroviral failure in the southern African private sector
… 15 years in South Africa. Many patients develop HIV drug resistance mutations when they fail first-line ART. The effect of different drug regimens and other patient related factors on drug resistant mutations selected at first line failure are not well characterised in Southern Africa with its …
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Human immunodeficiency virus type 1 diversity in patients initiating treatment in Northern South Africa
… human ranges. This in turn is expected to reduce HIV transmission thereby, leading to a decreased spread of the virus and eventual elimination of the virus from the human population. Findings from these trials resulted in the near global adoption of universal test and treat program. The program …