Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"HIV cure"”.
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Cell intrinsic innate immunity protein RPRD2 restricts transcription from the HIV-1 LTR in human cell lines
HIV-1 establishes latency after infection in resting CD4+ T-cells which prevents the host from clearing the virus. Highly active antiretroviral therapy effectively keeps HIV replication under control, however, the latent reservoir remains unaffected, thus therapy is never curative. The …
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Platinum and palladium complexes as human immunodeficiency virus latency reversal agents
The Persistence of latent HIV-1 provirus and reservoirs presents a formidable challenge in human immunodeficiency virus (HIV/AIDS), numerous efforts have been made to develop vaccines and chemotherapeutic agents. However, an effective vaccine remains elusive, and existing HIV/AIDS medications do …
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Integration Sites in the Persistence of Latent HIV-1
<p>Human immunodeficiency virus (HIV-1), the pathogen that causes acquired immune deficiency syndrome (AIDS), remains one of the world's most pressing health issues. Since the beginning of the HIV/AIDS epidemic, over 32M people have succumbed to AIDS-related illnesses. Despite remarkable advances …
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SMAC Mimetics Sensitize HIV-Infected Cells to MG1-Mediated Death
The main challenge in finding an HIV cure is the targeting and elimination of the HIV reservoir of latently infected CD4+ T-cells and persistently infected macrophages. While these cells are phenotypically indistinguishable from their healthy counterparts, they display impairments in their …
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Single-molecule diagnostics to support curative interventions for tuberculosis and HIV
… (TB) and the human immunodeficiency virus (HIV) are two of the leading causes of death worldwide. Tuberculosis is curable, but because of the difficulties of diagnosing it, many people with TB—and the majority of those killed by it—never begin treatment. HIV can be treated with lifelong …
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Molecular Mechanisms and Host Factors Involved in HIV-1 Latency
… low levels of G-to-A transition mutations in the HIV-1 LTR region, introduced by APOBEC3G/F, could lead to a latency-like phenotype. These latent viruses pose major hurdles for HIV-1 cure therapies. Our lab previously created a library of clones possessing mutations in the LTR introduced by A3G/F. …