Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"HIV antibody"”.
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Efficient New Computational Protein Design Algorithms, with Applications to Drug Resistance Prediction and HIV Antibody Design
… and (ii) the re-design of a monoclonal HIV antibody for improved potency and breadth of neutralization.</p>
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The intersection of the HIV epidemic and blood donation in South Africa
… Africa's large population of people living with HIV (PLWH) affects the local blood transfusion services (BTS) in multiple ways, including the recruitment of safe donors, the demand for blood and the development of blood safety policies. The latter includes the deferral of persons at risk of …
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Laboratory investigation of low positive and discrepant HIV serology results
… laboratory, we test on average 1500 samples for HIV antibody/antigen each month, of which 0.6% produces problematic results. These problematic samples produce either weakly reactive screening and confirmatory results or, discrepant screening and confirmatory results. Both scenarios require …
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Characterization of Fc receptor family proteins in vaginal and endocervical epithelia
… with Human Immunodeficiency Virus Type 1 (HIV-1) are now living significantly healthier and longer lives. However, HIV prevention and cure still remain significant challenges. Globally, women face specific barriers to using and accessing both female and male condoms, the primary method …
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Pilot-scale process development for the purification of the recombinant antibody 2G12 from transgenic tobacco
… for the purification of the recombinant anti-HIV antibody 2G12. Different techniques were successfully combined into a process strategy to fulfill this objective. Clinical-grade recombinant antibody was purified using by the following process steps and industrially available equipment: manual …
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The economics of HIV testing in Africa
… of resource allocation in Africa to combat the HIV/AIDS epidemic. It focuses on the use of one specific technology, the anti-HIV antibody test. After describing the characteristics of the epidemic, the special problems that accompany the allocation of health resources in Africa are explored. A …
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The relationship between perceived stigma of HIV and willingness to be tested for HIV among young African American men who have sex with men in Illinois
… ages of 18-24 have a disproportionate rate of HIV. According to the CDC, YAAMSM account for more new infections in the United States than any other subgroup by race/ethnicity, age, and sex (CDC, 2016). To curtail the staggering rates of HIV, it is important to understand why YAAMSM are least …
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Psychosocial variance in the outcomes of pediatric HIV
… concluded that human immunodeficiency virus (HIV) causes developmental delays have compared infected children's scores to instrument norms (Epstein et al., 1986; Ultmann et al., 1984), rather than matched control subjects. Early intervention programs have found similar deficits for children …
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The performance of HIV rapid antibody detection assays in children
Background: HIV rapid antibody assays are important for screening children aged <18 months for HIV exposure and children ≥ 18 months for HIV infection. Limited available data indicate variable performance of different HIV rapid tests in comparison to laboratory HIV antibody assays. The aim of this …
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On Epitope-Paratope Interactions of Emerging to Endemic Viruses
… antibodies that bind virus epitopes via the antibody’s paratope domain in an epitope-paratope interaction (EPI). EPIs are key aspects of the dynamic interplay between the virus and the host immune response to neutralize the virus. Studying EPIs enables us to better understand viral …
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Expression and characterisation of biopharmaceuticals in heterologous expression systems
… proteins, the therapeutically relevant anti-HIV full-size IgG1/kappa antibody, (BY-2)2F5, and a soluble form of the high-affinity receptor for human IgG, Fc-gamma-RI (CD64), were successfully established and optimised for heterologous expression in plants, bacteria and mammalian. The first …
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Innate and humoral immune responses to HIV-1
… cellular and humoral immune responses to HIV-1 infection and designed HIV immunogens are imperative to the development of an effective anti-HIV vaccine. In this thesis we investigate aspects of both the cellular innate and adaptive humoral arms of the immune system in response to HIV-1 …