Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"HIV RNA"”.
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Impact of highly active antiretroviral therapy on hepatitis C virus RNA levels over one year in HIV-HCV co-infected individuals.
… antiretroviral therapy (HAART) on plasma HCV RNA level in HIV-HCV co-infected individuals is uncertain. This issue was investigated over 12 months in HIV-HCV co-infected subjects HAART-treated for at least six months and achieving HIV RNA suppression below 500 copies/mL. It was predicted that …
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Development of one-step single-cell RT-PCR for the massively parallel detection of gene expression
… that over 35 million people are afflicted with HIV/AIDS in the world. Highly active antiretroviral treatments (HAART) that use a combination of drugs that target the virus at different stages of its life cycle are effective at reducing the HIV plasma levels below levels detectable by the most …
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Evaluating individuals with extreme phenotypes of HIV-1 contributes towards better healthcare management of all HIV-1 positive individuals
Human Immunodeficiency Virus (HIV)-1 disease progression is variable within patients where some remain asymptomatic for long periods (elite controllers (EC)) while others rapidly progress to disease (rapid progressors (RP)), representing the ‘extreme phenotypes’. There is substantial heterogeneity …
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Sleep Homeodynamics And Wellbeing In Asymptomatic Hiv-Seropositive African American Women
… HOMEODYNAMICS AND WELLBEING IN ASYMPTOMATIC HIV–SEROPOSITIVE AFRICAN AMERICAN WOMEN</p> <p>by</p> <p>TABETHA LYNN GAYTON</p> <p>December 2013 </p> <p>Advisor: Hossein N. Yarandi, PhD</p> <p>Major: Nursing (Urban Health)</p> <p>Degree: Doctor of Philosophy</p> <p>BACKGROUND: HIV–related sleep …
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G-wires: The growth and characterization of a G4-DNA nanostructure
… regions, recombinational hot spots and the HIV RNA dimerization domain. The functions of these G-rich sequences rely in part on guanine self-recognition. G-rich sequences can adopt a quadruple helical conformation in the presence of specific monovalent and divalent metal cations which are …
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Developing potential drugs for the treatment of myotonic dystrophy: from rational design to lead development
… Nevertheless, it is known that the alternative splicing regulator, MBNL1, is sequestered by two types of abnormally long RNAs. Specifically there are the tri- and tetra-nucleotide repeats, CUG and CCUG, in DM1 and DM2, respectively. This key discovery inspired the development of ligands …
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Clinical Implications of HIV-1, HSV-2 Co-infection and Opportunities for Intervention
HSV-2 may have adverse consequences in HIV. I evaluated the impact of HSV-2 co-infection on (highly active antiretroviral therapy)-untreated HIV infection in a systematic review of observational studies (study 1) and a retrospective cohort (study 2). I further evaluated whether HSV reactivation …
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Analysis of Protein and RNA Interactions of the HIV-1 rev Protein
<p>The HIV-1 Rev protein enters the nucleus via it’s nuclear localization sequence/RNA binding domain and interacts with a ≈234 nt region of viral RNA, termed the Rev Response Element (RRE), which is located in the <em>env</em> region of unspliced and singly-spliced HIV-1 mRNA. The Rev nuclear …
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The impact of medication therapy management on polypharmacy in people living with HIV/AIDS
… is increasingly common in people living with HIV/AIDS (PLWHA) due to the use of antiretroviral and non-antiretroviral drugs for the treatment of multiple chronic diseases. Polypharmacy is a growing concern among PLWHA because of their complex medication regimen, the risk of adverse drug …
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NMR Studies on Termination/- Antitermination Complexes of HIV-1 Transcription
After HIV enters the host cell the viral RNA is reverse transcribed into double stranded DNA and then integrated into the host genome. At this step, transcription of HIV RNA by Rpol II is tightly regulated by several cellular factors including NELF, DSIF, and pTEFb, and the virus encoded Tat …
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Identification and characterization of Risp
… the function of Rev in the host cell. The HIV-1 protein Rev plays an essential role in the temporal regulation of the virus gene expression by stimulating the expression of viral structural proteins. Rev enhances the nucleocytoplasmic transport and the translation of unspliced and single …
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Antiretroviral Treatment as Prevention in African HIV-1 Serodiscordant Couples: Understanding the Challenges and Opportunities
… and biologic and behavioral factors related to HIV-1 transmission risk in stable heterosexual HIV-1 serodiscordant African couples. ART is recommended for all HIV-1 infected persons, regardless of CD4 count, to reduce HIV-1 related morbidity, mortality and risk of transmission to uninfected …
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Assessment of Gamma/Delta T Cell Functionality Following Pathogenic HIV/SIV and Non-Pathogenic SIV Infections
Pathogenic HIV/SIV infection induces high viral loads, aberrant immune activation, and dysfunction in numerous immunologic cells (including gamma/delta (gamma delta ) T cells) leading to opportunistic infections. gamma delta T cells bridge the innate and adaptive immune responses primarily via …