Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"HIV Protease Inhibitors"”.
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Nutrient Transporter targeted Delivery of HIV Protease Inhibitors
HIV/AIDS has become one of the greatest threats to human health. Although inclusion of protease inhibitors (PIs) in HAART has greatly slowed the disease progression and improved the outcome of clinical treatment, the eradication of HIV/AIDS remains as a major medical challenge. Saquinavir (Saq) is …
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HIV Protease Inhibitors Trigger Lipid Metabolism Dysregulation Through Endoplasmic Reticulum Stress and Autophagy
<p>HIV protease inhibitors (PI) are core components of Highly Active Antiretroviral Therapy (HAART). HIV PIs are extremely effective at suppressing viral load, but have been linked to lipodystrophy and dyslipidemia, which are major risk factors for cardiovascular disease. Recent studies indicate …
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Identification of features contributing to binding promiscuity of small-molecule inhibitors for rapidly mutating targets
HIV infection has become a persistent worldwide epidemic despite the continuous development of novel inhibitors. A key challenge in combating HIV and other pandemic viral infections is the ability of the virus to mutate at an enormous rate and rapidly develop resistance to existing drugs. Among the …
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Discovery and development of novel antifungal agents for the treatment of Candida auris infections
… antifungals. This screening revealed that HIV protease inhibitors, such as lopinavir, atazanavir, saquinavir and ritonavir, significantly enhanced the antifungal activity of azoles (fluconazole, voriconazole, itraconazole, and posaconazole) and polyene (AmB). Mechanistic studies showed that …
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Developing novel drug combinations for treatment of invasive fungal infections
… amphotericin B against resistant C. auris. The HIV protease inhibitors (lopinavir and ritonavir) were identified as potent enhancers to the antifungal activity of azole drugs (fluconazole, voriconazole and itraconazole). We confirmed that lopinavir and ritonavir have the capability to interfere …
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Computational engineering of small molecules to treat infectious diseases
… mutations in infectious diseases often render inhibitors ineffective and are one of the key clinical failures of current therapies. We use HIV protease as a model system to understand mutation resistance. HIV protease substrates are unaffected or only moderately affected by resistance mutations …
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Keteneylidenetriphenylphosphorane as a Versatile C-2 Building Block Leading to Tetronic Acids with Potential Herbicidal and anti-HIV Activity
… derivatives have been found to be important HIV-1 protease inhibitors. This work is concerned with using keteneylidenetriphenylphosphorane as a new route to highly functionalised HIV-protease inhibitors. New synthetic techniques such as microwave irradiation is investigated as a means to …
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EVASION OF EFFLUX AND ENHANCING BIOAVAILABILITY OF AMPRENAVIR BY PRODRUG DERIVATIZATION
… have been infected with human immunodeficiency (HIV). Highly active antiretroviral therapy (HAART) has substantially improved the clinical management of HIV-1 infection. Inclusion of HIV protease inhibitors (PIs) in HAART has substantially improved clinical outcomes of HIV infected patients. …