Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"HIV Protease Inhibitor"”.
-
Prodrug Approach to Improve Oral and Brain Absorption of HIV Protease Inhibitor, Lopinavir
The main objective of this project is to develop prodrug strategies to circumvent efflux pumps such as P-glycoprotein (P-gp) and multidrug resistance associated proteins (MRPs), thereby enhancing oral and brain absorption of lopinavir (LPV). Oral absorption of LPV is severly limited due to low …
-
What can't be cured must be endured: Optimisation of HIV Protease Inhibitor-Containing Antiretroviral Therapy
Item does not contain fulltext
-
Design and synthesis of substituted cyclopropanes as conformationally restrained dipeptide mimics
… which include the flexibility of substrates and inhibitors in solution, the paucity of enzyme structural information, and the dynamic nature of the enzyme/substrate complex structure. Recent advances in X-ray crystallography and molecular modeling have allowed researchers to determine the …
-
Disubstituted BIS-THF moieties as new P2 ligands in nonpeptidal HIV-1 protease inhibitors
HIV-1 protease inhibitors (PIs) remain a powerful tool in the battle against HIV. The recently approved nonpeptidal HIV-protease inhibitor darunavir has been reported to be highly active against the wild-type virus as well as against a series of mutant strains. A rigid bis-tetrahydrofuran (bis-THF) …
-
Synthesis of proteasome inhibitors: analogues of nelfinavir
… been found to be a very successful nonpeptidic HIV-protease inhibitor. According to a previous investigation, nelfinavir 1 proved to have an inhibitory effect on chymotrypsin-like activity of 20S proteasome. Previous studies also show the promotion of acceleration of the apoptosis process within …
-
Synthesis and Characterization of Poly(lactide) Functional Oligomers and Block Copolymers
… of potential core-shell delivery vehicles for HIV drugs. PEO-b-PDLLA block copolymer was used as a polymeric nanocarrier to encapsulate the HIV protease inhibitor, Ritonavir, within magnetite nanoparticles. Well-defined multifunctional polymeric nanoparticles with controlled sizes and size …
-
Stimulating antibiotic development by targeting virulence and facilitating natural product discovery
… chapter 2, I demonstrate that the FDA approved HIV protease inhibitor nelfinavir can be repurposed as an inhibitor of the biosynthesis of the Streptococcus pyogenes cytolytic toxin streptolysin S. Nelfinavir was utilized to explore the proteolytic processing step in streptolysin S biosynthesis …
-
Von cyclischen, olefinischen Kohlenwasserstoffen zu enantiomerenreinen, N,O-perfunktionalisierten C6/C12-Bausteinen
Ausgehend von gut verfügbarem Cyclohexa-1,4-dien wurden flexible Syntheserouten zu optisch reinen, perfunktionalisierten Verbindungen erarbeitet. Diese sind als Bausteine für Synthesen im Hinblick auf Wirkstoffe von Interesse. Die Arbeit unterteilt sich in drei Abschnitte: (1) Stereoselektive …