Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"HIV/SIV"”.
-
Assessment of Gamma/Delta T Cell Functionality Following Pathogenic HIV/SIV and Non-Pathogenic SIV Infections
Pathogenic HIV/SIV infection induces high viral loads, aberrant immune activation, and dysfunction in numerous immunologic cells (including gamma/delta (gamma delta ) T cells) leading to opportunistic infections. gamma delta T cells bridge the innate and adaptive immune responses primarily via …
-
The G-protein coupled receptor CMKLR1/ChemR23: Studies on gene regulation, receptor ligand activation, and HIV/SIV co-receptor function
… in human and simian immunodeficiency virus (HIV-1 and SIV)-infection of CD4+ immune cells. We have described the genomic organization of cmklr1 in mouse and analysed the regulatory mechanism behind the corresponding receptor expression. Two transcripts of mouse cmklr1 have been identified, …
-
Characterization and Development of a Novel Cytomegalovirus for Evaluation as an HIV Vaccine Viral Vector in a Non-Human Primate Model
Within the field of HIV vaccine design, it has been recognized that there is a real need to diversify the pool of vectors undergoing testing and to utilize vectors that can induce durable immunity. Herpesviruses, such as cytomegalovirus (CMV), show much promise as viral vectors, as they establish …
-
Use of peptide microarrays for mapping viral b cell epitopes
… der HBV-Sequenz und des Hüllproteins des HIV von Dr. Frank, HZI Braunschweig, synthetisiert (Frank 1992) und auf mikroskopische Objektträger gedruckt (Dikmans, Beutling et al. 2006). Zusätzlich wurde eine Bibliothek aus 4608 unterschiedlichen, Zufalls-generierten 15-mere Peptiden verwendet …
-
Kinetik von NK-Zellen und gamma-delta-T-Zellen nach Infektion von Rhesusaffen mit Immundefizienzviren
Human immunodeficiency virus (HIV) infection and the caused acquired immunodeficiency syndrome (AIDS) developed over the last 25 years to a pandemic. In 2006 more than 39 Million people were HIV positive. Based on the high concordance with the human and viral system, rhesus macaques infected with …
-
Evaluating the Conservation of RNA Packaging Enhancer Elements Across Lentiviruses
… were the sole determinants of RNA packaging in HIV-1. However, in 2013 Chamanian et al. discovered that the region overlapping the Ribosomal Frameshift Signal (RFS) acted to enhance RNA packaging 50 fold and was thus named the genomic RNA packaging enhancer element (GRPE). To determine if the …
-
Bedeutung der mikrobiellen Transmission im SIV-Rhesusaffen-Tiermodell für die HIV/AIDS-Pathogenese
… eine wesentliche Ursachen des Fortschreitens der HIV-Infektion bis ins AIDS-Stadium angesehen. Es gibt Hinweise dafür, dass die Aktivierung von Immunzellen durch mikrobielle Translokation über die geschädigte Darmmukosabarriere verursacht wird. Um den Zusammenhang zwischen mikrobieller …
-
Construction of a Simian Immunodeficiency Virus Vaccine from Cynomolgus Macaque Cytomegalovirus
The current HIV pandemic has killed more than 35 million people since 1985, and infects a further 30 million globally. Vaccines based on herpesvirus vectors, in particular cytomegalovirus, generate unique, robust immune responses that may overcome many of the typical obstacles to an effective …
-
Charakterisierung von Mikrogliafunktionen im Simianen Immundefizienzvirus (SIV) - Rhesusaffentiermodell für AIDS
Rund 60% der HIV-infizierten Patienten sind von neurologischen und psychiatrischen Symptomen betroffen. Die unter dem Begriff HIV-1 assoziierte Demenz zusammengefassten motorischen und kognitiven Einschränkungen, sowie Verhaltsänderungen, lassen sich durch einen signifikanten Funktionsverlust der …
-
Virus tropism and neutralization response in SIV infection
Simian immunodeficiency virus (SIV) infections in macaques are commonly used as models to study the pathogenesis of human immunodeficiency virus (HIV). Both SIV and HIV normally use the CD4 receptor and an additional coreceptor for cell entry. The most common coreceptors used by HIV are CCR5 and …