Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"HISTONE DEACETYLASE INHIBITORS"”.
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Discovery of Isozyme Selective Histone Deacetylase Inhibitors.
Discovery of Isozyme Selective Histone Deacetylase Inhibitors.
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EFFECTS OF HISTONE DEACETYLASE INHIBITORS ON ENERGY METABOLISM
… involving enzymes, such as members of the histone deacetylase (HDAC) family, in particular those belonging to class I and class II, which modulate post-translational modifications on target proteins. The current knowledge on HDACs is that they function in general as transcriptional …
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Oxidative Stress Based Strategies For Enhancing The Efficacy of Histone Deacetylase Inhibitors (Hdaci)
<p>Histone deacetylase inhibitors (HDACi) are anti-cancer drugs that primarily act upon acetylation of histones, however they also increase levels of intracellular reactive oxygen species (ROS). We hypothesized that agents that cause oxidative stress might enhance the efficacy of HDACi. To test …
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The synergistic interaction between CD20 monoclonal antibodies and Histone Deacetylase inhibitors in B cell Non Hodgkin’s Lymphoma
… patients with B cell Non Hodgkin’s<br/>lymphoma. Histone deacetylase inhibitors are a novel class of anti cancer<br/>agents targeting epigenetic regulation.<br/><br/>This thesis addresses the interaction between histone deacetylase inhibitors<br/>and anti-CD20 monoclonal antibodies, including …
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Histone deacetylase inhibitors as novel neuroprotective agents in in vitro and in vivo models of Parkinson’s disease
Histone deacetylases (HDAC) shift the balance towards chromatin condensation and silence gene expression. Aberrant recruitment of HDACs to alter transcription suggests the use of HDAC inhibitors (HDAC-Is) as potential therapeutic candidates for neurodegenerative disorders such as Parkinson’s …
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An improved synthesis of the HDAC inhibitor trichostatin A
<p>Histone deacetylase inhibitors (HDIs) have found a wide variety of medicinal uses and are most noted for their specific apoptotic action towards cancer cells. Several hydroxamate HDIs have since been moved on to phase 1 and 2 clinical drug trials, with one having already been approved for …
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Probing the role of histone acetylation in the evolution of pathogenicity in <i>Candida glabrata</i>
… level. Comparative genomics suggests that histone modification-related genes are under positive selection in this species, and polymorphisms in these genes have influenced the adaptation of this species to the human host environment.<br/>Analyses conducted in this project suggest that …
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Genomic Analysis of Chemo-Resistance to HDAC inhibitor in Gastric Cancer cells
Histone deacetylase inhibitors (HDACis) are a promising class of anticancer epigenetic drugs, however, molecular factors influencing the responses of individual tumors to HDACi therapies remain obscure. Here, we sought to identify genes associated with HDACi resistance in gastric cancer. Treating a …
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Definition of The Landscape of Chromatin Structure At The Frataxin Gene In Friedreich’S Ataxia
… A number of studies demonstrated that specific histone deacetylase inhibitors (HDACi) affect either histone modifications at the <em>FXN</em> gene or <em>FXN</em> expression in FRDA cells, indicating that the hyperexpanded GAA repeat may facilitate heterochromatin formation. However, the …
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Therapeutic testing and epigenetic characterization of Friedreich Ataxia
… heterochromatin, suggesting the use of histone deacetylase inhibitors (HDACi) as FXN up-regulators. Therefore, therapy with a benzamide-type HDACi (106) was similarly investigated on the FXN YAC GAA mouse model. No significant improvements were detected by functional and histochemical …
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MOLECULAR STUDY OF CHROMATINOPATHIES: THE CASE OF RUBINSTEIN-TAYBI AND RETT SYNDROMES
… treatments. Indeed, we tested exogenous histone deacetylase inhibitors (HDACi) in in vitro cellular models (lymphoblastoid cell lines derived from patients and healthy donors) and on a Drosophila melanogaster model of RSTS (nej) and wild type flies (yw), performing acetylation and …
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Proteins Involved in HDACi Induced Decay of ERBB2 Transcripts in Breast Cancer
… will soon develop resistance to these agents. Histone deacetylase inhibitors (HDACi) are a powerful new class of epigenetic therapeutics that have demonstrated potent antitumor activity. However, there are several concerns that need to be addressed regarding the clinical usage of pan-HDACi …
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Multiomic Analyses Reveal Epigenomic Alterations and New Targets of Polycomb Repressive Complex 2 in Schwann Lineage Cells and Malignant Peripheral Nerve Sheath Tumors
… or SUZ12, leading to loss of trimethylation of histone H3 on lysine 27 (H3K27me3), a repressive epigenetic mark. Consequently, PRC2 dysfunction may induce significant epigenomic and gene expression alterations. Our research aimed to understand mechanisms underlying benign-to-malignant tumor …
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The Role of Histone Deacetylases in Cytokine Regulation in Human Gestational Tissues
… their investigation as anticancer drugs, histone deacetylase inhibitors were identified as having anti-inflammatory actions, leading to further studies into how histone deacetylases may be involved in cytokine regulation. However, despite the importance of appropriate histone deacetylase …
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Regulation of Metabolic Processes by Micrornas and Class I Histone Deacetylases
… in obesity. Thus, the modulation of epigenetic histone modifications and microRNA functions represents a potentially powerful approach for the treatment of metabolic disorders. We show that the Ppargc1b gene, which encodes the PGC-1β protein, also co-transcribes two microRNAs, miR-378 and …
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Roles of Cytoplasmic Deacetylase Hdac6 in Oncogenic Tumorigenesis
… structure and gene expression. Acetylation of histone is associated with transcriptional activation while deacetylation is linked to transcriptional repression. Moreover, histone deacetylase inhibitors induce growth arrest, differentiation and apoptosis of cancer cells and therefore appear to …
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The Design and Synthesis of Novel Barbiturates of Pharmaceutical Interest
Barbituric acids have been historically classified as compounds that act on the central nervous system, and as such provide therapeutic uses as anxiolytics, sedatives, hypnotics, and anticonvulsants. Recent investigations of barbituric acid derivatives have provided scientists with information that …
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Elucidating the mechanisms and dynamics of drug-mediated inhibition and latency reversal in HIV-1 (HIV-1)
… drugs, Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs), and LRAs, to better understand the mechanisms by which each drug class inhibits and reactivates HIV-1 replication respectively, to aid in the effort towards the development of antivirals that will lead to HIV-1 eradication. …
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Effekte der Antiepileptika Carbamazepin und Lamotrigin auf das Prostatakarzinom
… üben ihren Einfluss durch Modifikation der Histone aus. Durch diese Modifikation werden verschiedene Gene rektifiziert. Um das Spektrum der Histondeacetylaseinhibitoren zu erweitern habe ich nach weiteren Medikamenten (Carbamazepin und Lamotrigin) gesucht, die helfen, das Prostatakarzinom …
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The Histone Deacetylase Inhibitor, Ms-275, Sensitizes Metastatic Osteosarcoma to Fasl-Induced Cell Death: A Role For C-Flip
… this study was to determine the effects of the histone deacetylase inhibitor, MS-275, on the Fas signaling pathway and susceptibility of osteosarcoma (OS) to Fas ligand (FasL)-induced cell death. OS metastasizes almost exclusively to the lungs. We have shown that Fas expression in OS cells is …
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