Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"HIPSCI"”.
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Using single-cell RNA-seq to assess the effect of common genetic variants on gene expression during development
… human induced pluripotent stem cell initiative (HipSci) project.
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Human Cellular Genetics of Innate Immunity
… of 70 healthy human individuals from the HipSci initiative. Chapter 2 describes optimisation of stimulation conditions to induce an antiviral response, and the experimental work carried out on the panel of donors. In Chapter 3, I analyse heterogeneity in resting (unstimulated) fibroblasts. …
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The Malleability of Gene Regulation in Healthy Individuals: Analyzing CRISPR-based Screens with Single-Cell RNA-Sequencing Readout across Genetic Backgrounds
A question that has driven the field of quantitative genetics since its inception, is that of understanding the relationship between genetic variation and complex traits. In the last few decades, genome-wide association (GWAS) and quantitative trait studies have implicated thousands of genetic loci …