Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"HIFs"”.
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V-ATPase regulation of Hypoxia Inducible transcription Factors
… of Hypoxia Inducible transcription Factors (HIFs). In aerobic conditions, HIFs are inactivated by ubiquitin-proteasome-mediated degradation of their a subunit, which is dependent on prolyl hydroxylation by 2-oxoglutarate (2-OG) and Fe(II)-dependent prolyl hydroxylases (PHDs). In hypoxia, …
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Modeling, Detection, and Localization of High-Impedance Faults In Low-Voltage Distribution Feeders
High-impedance faults (HIFs) on distribution feeders are abnormal electrical conditions that cannot be detected by conventional protection schemes. These faults pose a threat on human lives when neighboring objects become in contact with the line's bare and energized conductors. An accurate …
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Investigation of the anticancer activity and molecular mechanisms of Disulfiram in Glioblastoma Multiforme
… suggests that hypoxia inducible factors (HIFs), NF-B and aldehyde dehydrogenase (ALDH) together orchestrate the stemness and chemoresistance in hypoxia induced CSCs. But the insights on the mechanisms still remain obscure. In this study we used an in vitro GBM CSC and hypoxia model along …
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Genes, haplotypes and physiological traits associated with a chromosome 3B locus for wheat improvement in hot climates
… The lines with the RAC875 allele among the HIFs increased biomass, single grain weight and number of spikelets per spike. Water use was also measured in the deep soil platform using sap flow sensors. RAC875 had an increased water use compared to Kukri. A similar pattern was observed in the …
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The Role of The Hypoxia-Inducible Factor 2 In Pancreatic Cancer: Mechanisms of Tumor Immunosuppression and Intestinal Radioprotection
… This dissertation examines the roles of the HIFs in PDAC with the objective of exploiting this tumor’s profoundly hypoxic status to improve immunotherapy and radiotherapy.</p> <p>We used a dual recombinase mouse model that developed autochthonous PDAC and restricted the deletion of HIFs to …
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Differential Angiogenic Capability and Hypoxia Responses in Glioma Stem Cells
… genes, including the hypoxia-inducible factors (HIFs)-1a and -2a(EPAS-1) were differentially expressed in GSCs in comparison to non-stem glioma cells and normal neural progenitors. GSCs preferentially induced HIF2a; and HIF2a-regulated genes under hypoxia in comparison to non-stem glioma cells. …
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The role of ABHD11 in the regulation of the hypoxia inducible transcription factors
Hypoxia inducible transcription factors (HIFs) mediate a highly conserved cellular oxygen sensing system, driving a diverse set of transcriptional changes that allow adaptation to hypoxic conditions. However, HIFs can also be activated independently of oxygen by changes in levels of mitochondrial …
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Generation and Transcriptomic Analysis of HIF-1Alpha and HIF-2Alpha Knockout 5TGM1 Multiple Myeloma Cells
… Hypoxia-Inducible Factor (HIF) signalling. The HIFs are heterodimeric transcription factors that activate the transcription of hundreds of target genes in response to hypoxia. In most solid tumours, HIF signalling is co-opted to contribute to tumour survival and progression. However, the role of …
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Investigation of chemoresistant mechanisms in triple negative breast cancer cell lines and development of a nano-enabled Disulfiram for breast cancer treatment
… kappa B (NFB) and hypoxia inducible factors (HIFs) also play pivotal roles in chemoresistance. Forced expression of NFB and HIFs by transfection with p65 subunits of NFB and HIF1α and 2α subunits induced CSCs characters and resistance to a range of anticancer drugs in TNBC cell lines. My …
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THE HYPOXIC HEMATOPOIETIC STEM CELL NICHE Consequences of Hypoxia-induced Transcription on Stem Cell Fate
… We have investigated the role of hypoxia and HIFs in HSC biology. By in vitro hypoxic treatment, we could show that hypoxia leads to less proliferation of HSCs, with up-regulation of cell-cycle inhibitory genes, while full reconstitution potential of irradiated recipient mice is preserved. …
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HYPOXIA-REGULATED EXPRESSION OF GLUT-1 IN GBM CELL LINES
… expression levels of hypoxia inducible factors (HIFs) as well as GLUT1. HIF-1b and GLUT1 appear to have different expression levels in fibroblast cells than in GBM cells, solidifying that HIF-1b and GLUT1 are suitable targets for future GBM treatments.</p>
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A Novel Method for the Location of High Impedance Faults
… localization. Locating High Impedance Faults (HIFs) is specifically challenging because of their variable and nonlinear nature. Most existing approaches focuses on identifying the accurate fault distance occurring in the main trunk of a system, often leaving lateral branches as blind spots. To …
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Role of Fam60a in the Regulation of HIF-2α and Determination of Stem Cell Fate
… are sensed by the Hypoxia-Inducible Factors (HIFs). The HIFs are a family of transcription factors that are master regulators of over 100 genes and can effect changes in multiple cellular processes including migration, survival and differentiation. The broad nature of the response to hypoxia …
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Identification of Novel HIF1A Target Genes That Regulate Tumor Progression and Metastasis
… are the master regulators of this response. HIFs play key roles in many critical aspects of cancer biology including angiogenesis, stem cell maintenance, metabolic reprogramming, invasion, metastasis and resistance to radiation therapy and chemotherapy. Overexpression of HIF-1α and HIF-2α has …
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Progesterone Receptor Regulation of the Gene Networks That Control Ovulation in Mice
… gamma (PPARgamma), hypoxia-inducible factors (HIFs), and interleukin-6 (IL-6) as critical regulators of ovulation. These factors function as the downstream mediators of the PR signal to bring about the rupture of a mature ovarian follicle. The knowledge gained from this study would help us …
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Hypoxic Influences On Myeloid Cells During Inflammation And Inflammation-Associated Cancer
… upon loss of myeloid ARNT. However, myeloid HIFs are dispensable for leukocyte influx in a peritonitis model and animal survival in an endotoxemia model. Collectively, these data suggest that HIF-αs adopt diverse roles during inflammation, and their functions highly depend on specific types …
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Chemistry to Biology and Back Again: Small Molecule Regulation of HIF Transcription Factors and the Development of a Platform for the Discovery of New Biocatalyzed Organic Transformations
… factors known as hypoxia inducible factors (HIFs) is up regulated. Importantly, the hypoxic response pathway is often mis–regulated in cancer. As a result, the regulation of this pathway offers a promising target for cancer treatment. Previous work on HIF identified a large internal cavity, …
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Regulation of Protein Degradation at the Endoplasmic Reticulum
… response, driven by hypoxia-inducible factors (HIFs), but instead relies on SREBP2. I find that SREBP2 protein levels are reduced in hypoxia which are partially rescued by proteasome inhibition, suggesting that SREBP2 protein degradation occurs when oxygen is scarce. Recently, using forward …
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Translational Aspects of Erythropoietin Receptor and Hypoxia-Inducible Factors in Breast Cancer
… response are the hypoxia-inducible factors (HIFs) 1 & 2. We have investigated HIF-1α and HIF-2α expression in breast cancer and found a correlation between HIF-2α expression and distant metastasis and impaired prognosis, suggesting that HIF-2α has an important role in tumor progression. We …
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Mechanisms of Synthetic Lethality in Renal Cell Carcinoma
… for targeting Hypoxia Inducible Factors (HIFs) for proteasomal degradation. Accumulation of the HIF-2α isoform, in particular, drives renal tumourigenesis. *VHL* loss occurs at an early stage of ccRCC development, often several years before the clinical manifestation of disease, and so is …
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