Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"HIF2A"”.
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Characterisation of HIF2A targets identifies MYC as a key determinant of HIF2A dependency in ccRCC
… cases and results in constitutive activation of HIF2A, making HIF2A an important clinical target. While HIF2A inhibitors are showing promising results in clinical trials, many patients do not respond and ultimately most patients progress. To improve our understanding of HIF2A dependency in …
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HIF2a regulates ccRCC tumorigenesis through activation of cell cycle regulators
Clear cell renal cell carcinoma (ccRCC) is the most frequent type of kidney cancer, with 50% 5-year survival. Genetically, ccRCCs are characterised by inactivation of VHL which is lost in 90% of cases. Inactivating mutations of VHL lead to stabilisation of HIF2α which in turn drives the expression …
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Endogenous Reporter Systems for High-Throughput Functional Screening in Clear Cell Renal Cell Carcinoma
… to the stabilization of hypoxia inducible factor HIF2A and aberrant expression of its downstream targets such as the chemokine receptor CXCR4. Activation of HIF2A has been shown to be important for ccRCC tumour initiation and early progression and the expression of CXCR4 promotes metastatic …
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Differential Angiogenic Capability and Hypoxia Responses in Glioma Stem Cells
… neural progenitors. GSCs preferentially induced HIF2a; and HIF2a-regulated genes under hypoxia in comparison to non-stem glioma cells. In contrast, neural progenitor/stem cells did not induce HIF2a in response to hypoxia suggesting that the HIF2a hypoxic response is not a general stem cell …
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A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in clear cell renal cell carcinoma
… suppressor gene and consequent accumulation of HIF2A that drives tumourigenesis. The current clinically-approved therapies for ccRCC are those targeting the angiogenesis and mTOR signalling pathways, however, the overall patients’ objective response rates are still low, and patients rapidly …
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A Cancer-Specific Study On The Differentially Expressed Protein-Protein Interactions of Fumarate Hydratase
… compared to its other isoforms (HIF1a and HIF2a), this research contributes to bridging that knowledge gap. Our findings suggest that the HIF3a gene is a significant, differentially expressed gene in FH deficient patients.</p>
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"Interrogating the genomic and metabolomic landscape of pseudohypoxic phaeochromocytoma and paraganglioma syndromes"
… Endothelial PAS domain protein 1 (EPAS1 or HIF2A) is another pseudohypoxia-associated gene that is rarely identified in sporadic PPGLs and, in the postzygotic somatic mosaic state, leads to the development of Pacak-Zhuang syndrome, associated with a high metastatic rate[6]. There is a …
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Transcriptional Regulation of Neural Crest-Derived Pharyngeal Arch Artery Development
… ductus arteriosus during development along with Hif2a and Ap2ᠡnd that, through epistatic relationships and negative feedback regulation, these three factors cooperatively regulate development of the specialized, neural crest-derived smooth muscle of this vessel.
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Transcriptional Regulation of Neural Crest-Derived Pharyngeal Arch Artery Development
… ductus arteriosus during development along with Hif2a and Ap2ᠡnd that, through epistatic relationships and negative feedback regulation, these three factors cooperatively regulate development of the specialized, neural crest-derived smooth muscle of this vessel.
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Oncostatin M Receptor Overexpression Promotes Tumour Progression in Squamous Cell Carcinoma, via Hypoxia Signalling and Multiple Effects on the Tumour Microenvironment
… Hypoxia inducible factor 1a and 2a (HIF1a, HIF2a) signalling in normoxic conditions, to promote pro-angiogenic signalling. Furthermore, hypoxic conditions were found to enhance OSM signalling in OSMR overexpressing cells leading to increased expression of markers of epithelial to mesenchymal …