Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"HIF2α"”.
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HIF2a regulates ccRCC tumorigenesis through activation of cell cycle regulators
… mutations of VHL lead to stabilisation of HIF2α which in turn drives the expression of multiple target genes involved in ccRCC initiation. However, it is unclear whether HIF2α activation is necessary for tumour maintenance. This is of particular interest because current ccRCC therapies are …
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Role of PBRM1 in regulation of the HIF pathway
… of VHL leads to upregulation of both HIF1α and HIF2α. However, recent studies indicate that HIF1α and HIF2α play opposing roles in renal cancer progression: HIF1α is a tumour suppressor whereas HIF2α acts an oncogene. Here, it is shown that PBRM1 is able to selectively regulate the expression of …
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Mechanisms underlying establishment and maintenance of pregnancy
… factor hypoxia-inducible factor 2 alpha (Hif2α), which is induced in subluminal stromal cells at the time of implantation, plays a crucial role during early pregnancy. Indeed, when preimplantation endometrial stromal cells are exposed to hypoxic conditions in vitro, we observed a striking …
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Role of glucose transporter 1 during pregnancy
… Our recent studies have indicated that Hif2α is induced by estrogen in the rodent uterus and plays an essential role in embryo implantation. Further studies using gene profiling has shown that Hif2α regulates Glucose transporter1 (GLUT1). GLUT1 is the dominant glucose transporter in the …
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Hepatic and Extra-hepatic Metabolism in NAFLD and the Role of Hepatocyte Oxygen Sensing
… kidney disease. Hypoxia-inducible factor 2α (HIF2α) accumulates in the livers of NAFLD patients and mouse models, and is a regulator of lipid metabolism. In this thesis, I investigated whether hepatocyte-specific deletion of *Epas1* (encoding HIF2α) protects against NAFLD, and whether this is …
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Amylin, tissue hypoxia and metabolic dysregulation in diabetic heart and liver
… stimulated hypoxic signalling, with elevated HIF2α levels being observed. Oxidative and energetic stress was also provoked. This resulted in downstream mitochondrial dysfunction and metabolic changes, including a lower Electron Transport Chain (ETC) capacity, and decreased fatty acid oxidation …
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The Role of Von Hippel-Lindau Protein in the Glomerulus
… 8 months of age. Furthermore, stabilization of HIF2α alone led to glomerular disease characterized by crescentic transformation. Collectively, these results indicate an alternative mechanism for the pathogenesis of RPGN and glomerular disease in an animal model and suggest novel molecular …
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Harnessing the Immunomodulatory Potential of Radiofrequency Ablation to Improve Therapeutic Outcomes in Pancreatic Ductal Adenocarcinoma
… and elevated hypoxia-inducible factor 2-alpha (HIF2α) expression were among the important componentsof the TME that were examined. Our data shows notable tumor-associated changes post-RFA, highlighting how EUS-RFA may enhance chemotherapeutic efficacy in PDAC. This study underscores RFA’s …
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The Role of The Hypoxia-Inducible Factor 2 In Pancreatic Cancer: Mechanisms of Tumor Immunosuppression and Intestinal Radioprotection
… improved survival. Moreover, deletion of <em>Hif2α </em>in CAFs decreased the recruitment of immunosuppressive macrophages and regulatory T cells and increased the presence of effector immune cells in tumors. CAF treatment with PT2399, a clinically relevant HIF2 inhibitor, significantly …
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From yeast to animals: A small molecule restores iron mobilization, absorption and hemoglobinization
… between hinokitiol and endogenous IRE- and Hif2α-mediated regulatory networks, with levels of ferritin, IRP2, TfR2, and FPN1 responding to changes in the dynamic iron status upon hinokitiol treatment. Administration of hinokitiol via oral gavage promotes gut iron absorption in DMT1-deficient …