Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"HIF-2Alpha"”.
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DNMT3a Epigenetic Program Regulates the HIF-2alpha Oxygen Sensing Machinery
… in the regulation of hypoxia-inducible factor (HIF) oxygen-sensing machinery. We show that DNA methyltransferase 3a (DNMT3a) methylates and silences the HIF-2alpha gene (EPAS1) in normal cells. Epigenetic silencing of EPAS1 prevents activation of the HIF-2alpha gene program associated with …
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Generation and Transcriptomic Analysis of HIF-1Alpha and HIF-2Alpha Knockout 5TGM1 Multiple Myeloma Cells
… are mediated through Hypoxia-Inducible Factor (HIF) signalling. The HIFs are heterodimeric transcription factors that activate the transcription of hundreds of target genes in response to hypoxia. In most solid tumours, HIF signalling is co-opted to contribute to tumour survival and progression. …
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Transcriptional Regulation by Hypoxia-Inducible Factors in Tumor Cells
… and activity of hypoxia-inducible factors (HIF), the master transcriptional regulators of oxygen homeostasis. Induction of ID2 expression occurs as an early HIF-mediated hypoxic event, potentially leading to a more immature state. HIF-1alpha and HIF-2alpha, however differently, are both …
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Role of the NF-kappaB-HIF Crosstalk in Inflammation and Hypoxia
… factor called Hypoxia Inducible Factor (HIF). HIF has recently been associated with a role in inflammation and immunity. Importantly, HIF-1alpha has shown to be regulated by the major inflammatory responsive transcription factor, NF-kappaB (nuclear factor kappaB). Here it is demonstrated …
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Mechanisms Regulating Pulmonary Sensitivity to Radiation
… hypoxia-associated gene expression, including HIF-1alpha; and HIF-2alpha; mRNA and protein stabilization, was dynamically altered during the temporal course of radiation pathogenesis in the "fibrosis-prone" C57BL/6J mice. As the C57BL/6J strain is more "resistant" to radiation-induced lung …