Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"HIF-1 Alpha"”.
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Inhibitors of tubulin, nitric oxide synthase, and HIF-1 alpha; synthesis, biological, and biochemical evaluation.
… to these areas. The transcription factor HIF-1α has been labeled as a primary target in treating the hypoxic areas of tumors. Drugs that are effective at inhibiting HIF-1α may be better suited for treating hypoxic tumor cells. Approximately 20 compounds were analyzed for their ability to …
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The Role of Secondary and Tertiary Structure in the Cap-Independent Translation of FGF-9 and HIF-1-alpha
… IRES-like translational enhancer, and the HIF-1-alpha 5’ UTR RNA, an oncogenic CITE-like translational enhancer, take on complex, distinct secondary structures. Protein toeprinting, DAP5 SHAPE footprinting, and UV crosslinking were used to map the binding sites of DAP5 along the FGF-9 and …
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The role of HIF-1 alpha in the localization of embryonic stem cells with respect to hypoxia within teratomas
… the hypoxia-inducible transcription factor, HIF- 1[alpha], has been shown to be a tumor suppressor, and HIF-1[alpha]-expressing cells have been shown to localize preferentially in vivo to regions near tumor vasculature. These differences were proposed to be due to increased hypoxia-induced …
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Influence of Preoperative Transcatheter Arterial Chemoembolization on Gene Expression in the HIF-1α Pathway in patients with Hepatocellular Carcinoma
… necrosis in tumors, hypoxia-inducible factor 1α (HIF-1α) could critically affect biology in residual tumors after TACE treatment and subsequent prognosis. However, HIF-1α and its prognostic relevance in TACE have rarely been examined in human specimens. In the current study, we …
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Transcriptional Regulation of human Plasminogen Activator Inhibitor-1 Gene Expression by Insulin-like Growth Factor-1, Insulin and Upstream Stimulatory Factor-2
… welches den Hypoxie-induzierbaren Faktor-1 (HIF-1) binden kann, hat die IGF-1- und Insulin-abhängige PAI-1-Promotor-Aktivität fast vollständig aufgehoben. Mutationen von E4 und E5 hatten keinen Einfluss auf die IGF-1-abhängige Induktion des PAI-1-Promotor-Konstrukts unter Normoxie; unter …
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Inhibition of progestin-induced VEGF in mammary cancer by curcumin and 2-methoxy estradiol and their potential role as anti-angiogenic & chemopreventive compounds
… rats. 2ME2 inhibits hypoxia inducible factor -1{alpha} (HIF-1[alpha]) and also prevents progestin-dependent VEGF release from tumor cells, suggesting that HIF-1[alpha] is an essential transcription factor for mediating the effects of progestins on VEGF elaboration. YC-1, a specific HIF-1[alpha] …
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Different Effect of 5-Fluorouracil on Expression of Genes Related to Aerobic Glycolysis According to Chemoresponsiveness in Gastric Cancer Cells
… which depends on the hypoxia-inducible factor 1α (HIF 1α). I investigated HIF1α expression and responsiveness to 5-FU in two different types of gastric cancer cells (MKN45, SNU216). In addition, we checked the change of the expressions of aerobic glycolysis related genes (GLUT1, …
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HIF-2: Standing Guard at the Crossroads of Stress and Aging
… include transcription factors, such as the α (alpha) subunit of Hypoxia inducible factors (HIF-1alpha and HIF-2 alpha). HIF-1 alpha and HIF-2 alpha have similar structural organization, and after forming an obligate heterodimer with the common partner ARNT/HIF-1 alpha, bind to the same …
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Reoxygenation of hypoxic coronary smooth muscle cells amplifies growth-retarding effects of ionizing irradiation
… oxygen species of these cells undergoing alpha-irradiation are changed by reoxygenation. <br>Hypoxic and reoxygenated HCSMCs were irradiated with alpha-radiation at single doses of 4, 8 and 16 Gy using a 60Co-source. Vascular endothelial growth factor (VEGF) gene expression was …
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Disassembly of electron transport chain complexes drives macrophage TLR responses by reprogramming metabolism and translation
… switch by inhibiting OxPhos and activating HIF-1[alpha]-dependent glycolysis. Disassembly of ETC complexes influences the global metabolic status of macrophages not only by inducing glycolysis but also largely by inducing the reprogramming of cellular translational capacity via mTORC1 and …
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Comparative hypoxia responses and oxygen sensing in galaxiid fishes
… protein hypoxia inducible factor 1 (HIF-1), the effect of inescapable moderate hypoxia at 5 mg L-1 dissolved oxygen concentration (without access to the water surface) on these parameters was investigated. Swimming speed decreased significantly from 21.6 ± 2.6 to 7.4 ± 2.0 BL min-1 in …
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Phospho-regulation and metastatic potential of Murine Double Minute 2
… of multiple angiogenic factors, including HIF-1 alpha and VEGF. Taken together my data provide novel insights into important p53-dependent and independent functions of Mdm2 that represent potential new avenues for therapeutic intervention.
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Identifying regulators of cytotoxic T cell function through molecular and genetic screening
… screen, which highlighted the importance of HIF-1$\alpha$ and NFIL3 in CTL killing. The second half of the thesis focuses on primary human CTL. The combined degranulation and killing assay was further validated using patient-derived CTL, indicating its potential as a diagnostic test. I showed …
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The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies.
… investigations revealed the possibility of HIF-1-alpha being involved in both the pathways. High glucose concentration-induced decrease in cell migration was successfully restored (p < 0.001) by the use of an anti-oxidant (silymarin). This could be due to anti-oxidant activity of silymarin …
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Chronic Hypoxia and Cardiovascular Dysfunction in Sleep Apnea Syndrome
… of VEGF, Akt-1, hypoxia inducible factor-1 alpha (HIF-1 alpha), and vascular endothelial growth factor receptor-2 (VEGFR2) gene expression by redundant oligonucleotide DNA microarray and real-time PCR technologies. Circulating angiogenic progenitor cells expressing VEGFR2 were profiled by …
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Generation and Transcriptomic Analysis of HIF-1Alpha and HIF-2Alpha Knockout 5TGM1 Multiple Myeloma Cells
… are mediated through Hypoxia-Inducible Factor (HIF) signalling. The HIFs are heterodimeric transcription factors that activate the transcription of hundreds of target genes in response to hypoxia. In most solid tumours, HIF signalling is co-opted to contribute to tumour survival and progression. …
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Regulation of cellular glucose metabolism by HIV-1 infection
… pathway via the Vpr-hypoxia inducible factor 1 alpha (HIF-1 alpha) axis to induce expression of hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD) and pyruvate kinase muscle type 2 (PKM2) that facilitates viral replication and biogenesis, and long-term survival of macrophages. We then …