Global ETD Search
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Showing 1 to 20 of 76 for “"HIF-1α"”.
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Regulation of HIF-1α during Hypoxia by DAP5-Induced Translation of PHD2
… unanticipated surge of hypoxia-inducible factor 1α (HIF-1α), the transcription factor and master switch of the hypoxia response. The hypoxia response is tempered through HIF-1α hydroxylation by the oxygen-sensing prolyl hydroxylase-domain protein 2 (PHD2), and subsequent ubiquitination and …
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Phosphorylation of ERα and HIF-1α in breast cancer with focus on tamoxifen response and links to kinase activation
… of the hypoxia inducible transcription factor 1α (HIF-1α). Silencing of Pak1 led to decreased HIF-1α levels and less transcriptional activity, suggesting that Pak1 phosphorylation stabilises HIF-1α and thereby increases HIF-1α’s ability to induce gene expression during tumour hypoxia.
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Mechanistic study of aryl hydrocarbon receptor nuclear translocator (ARNT)-mediated signaling
… Ainpl suppresses hypoxia inducible factor-1a (HIF-1α) signaling pathway through an ARNTdependent manner. HIF-1α is known to be overexpressed in more than 90% of solid tumors, and the inhibition of HIF-1α is proved as an effective approach to suppress tumor growth. ARNT, as the obligatory …
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HIF-1alpha role in oxygen-dependent radio- and chemosensitivity
… stabilisation of hypoxia-inducible factor-1α (HIF-1α) leads to changes in expression of various genes associated with growth, vascularisation and metabolism. However whether HIF-1α plays a causal role in promoting hypoxic resistance to antitumour therapies remains unclear. In this study we …
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Environmental signals that control T lymphocytes in the gastrointestinal tract
… (AHR) and also the Hypoxia Inducible Factor-1α (HIF-1α). Both the AHR and HIF-1α are key sensors of the microenvironment. Dietary tryptophan metabolites and microbiota catabolites are AHR ligands and HIF-1α is a sensor of low oxygen tension. Deletion of the AHR results in a loss of key …
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Inhibition of Breast Cancer Angiogenesis and Metastasis ay Targeting Hypoxia-Inducible Factor-1α
… response to proliferation. In animal models, HIF-1 (a heterodimer composed of one of the three alpha subunits-HIF-1α, HIF-2α or HIF-3α- and one constitutively expressed HIF-1β subunit) overexpression is associated with increased tumor growth, vascularization, and metastasis. The goal of this …
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Μελέτη των μοριακών μηχανισμών ανάπτυξης του οφθαλμικού πτερυγίου στον άνθρωπο : ο ρόλος του μεταγραφικού παράγοντα HIF-1α, της πρωτεΐνης pVHL και των πρωτεΐνών θερμικού σοκ
… μεταγραφικού παράγοντα Hypoxia-inducible factor-1α (HIF-1α), ο οποίος είναι γνωστό ότι παίζει κρίσιμο ρόλο στη ρύθμιση του μεταβολισμού των κυττάρων καθώς και στην επιβίωση των αρχέγονων κυττάρων (stem cells). Σε φυσιολογικές συνθήκες οξυγόνου η πρωτεΐνη von Hippel Lindau (pVHL) διατηρεί τα …
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Regulation of endometrial repair and its impact on heavy menstrual bleeding
… PGF2α (ii) the role of hypoxia inducible factor (HIF)-1α in endometrial repair and (iii) differences in endometrium from women with objectively measured HMB (>80ml) and normal controls (<80ml). METHODS/RESULTS: Putative repair factors, with known angiogenic, mitogenic and proliferative functions, …
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Invadopodia Formation in Breast Cancer
… transcription factor hypoxia-inducible-factor-1 (HIF-1α). However, little is known about how HIF-1α might influence the invasive behaviour of the cancer cells. Cell invasion requires actin cytoskeletal reorganisation and cells are thought to utilise specialised membrane protrusions termed …
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Defining the Role of Secondary DNA Structures and Transcription Factors on the Transcriptional Control of the HIF-1alpha and VEGF Promoters
… of the hypoxia inducible factor 1 alpha (HIF-1α) and human vascular endothelial growth factor (VEGF). In fact, tumor recurrence, aggressive metastatic legions and patient mortality rates are known to be positively correlated with overexpression of these two proteins. The HIF-1α and VEGF …
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Development of Hif-1Α/Hif-1Β Heterodimerization Inhibitors Using A Novel Bioluminescence Reporter Assay System For In Vitro High Throughput Screening and In Vivo Imaging
… heterodimerization of hypoxia-inducible factor (HIF)-1α and HIF-1β, which subsequently upregulates the expression of several hypoxia-inducible genes, promotes cell survival and stimulates angiogenesis in the oxygen-deprived environment. Hypoxic tumor regions are often associated with resistance …
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Generation and Transcriptomic Analysis of HIF-1Alpha and HIF-2Alpha Knockout 5TGM1 Multiple Myeloma Cells
… are mediated through Hypoxia-Inducible Factor (HIF) signalling. The HIFs are heterodimeric transcription factors that activate the transcription of hundreds of target genes in response to hypoxia. In most solid tumours, HIF signalling is co-opted to contribute to tumour survival and progression. …
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Expression of Vascular Endothelial Growth Factor(VEGF), Vascular Endothelial Growth Factor Receptor-1(VEGFR-1), Hypoxic Induced Factor-1alpha(HIF-1α) mRNA in Papillary Thyroid Microcarcinoma(PTMC)
… hypoxic induced factor-1alpha(HIF-1α) mRNA expression in PTMC. MATERIALS & METHODS: VEGF, VEGFR-1, HIF-1α mRNA expression was examined by RT-PCR in 14 patients who had undergone thyroidectomy due to PTMC. The thyroid tumor tissue and adjacent normal thyroid tissue were collected …
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Normal Glycolytic Enzyme Activity Is Critical For Hypoxia Inducible Factor-1A Activity and Provides Novel Targets For Inhibiting Tumor Growth
… is Critical for Hypoxia Inducible Factor-1α Activity and Provides Novel Targets for Inhibiting Tumor Growth</p> <p>By Geoffrey Grandjean</p> <p>Advisory Professor: Garth Powis, D. Phil</p> <p>Unique to proliferating cancer cells is the observation that their increased need for energy is …
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An investigation into the molecular mechanisms of hyperbaric oxygen using a human dermal microvascular endothelial cell line and a porcine retinal explant model.
… signalling (hypoxia inducible factor type 1 (HIF-1)). In this study, HDMEC and porcine retinal explants (a novel explant model) were exposed to treatments simulating HBOT using a bespoke HBO chamber (≥95% oxygen at 2.2 absolute pressures (2.2ATA) for 105 mins), or hyperoxia alone (HYP) (≥95% …
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Inhibitors of tubulin, nitric oxide synthase, and HIF-1 alpha; synthesis, biological, and biochemical evaluation.
… to these areas. The transcription factor HIF-1α has been labeled as a primary target in treating the hypoxic areas of tumors. Drugs that are effective at inhibiting HIF-1α may be better suited for treating hypoxic tumor cells. Approximately 20 compounds were analyzed for their ability to …
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HIF, HAPE, and Hilltop rats: a paradox unfolding
… control Madison rats. Hypoxia Inducible Factor-1α (HIF-1α) is exquisitely coupled to cellular hypoxia, enhancing expression of erythropoietin (EPO), vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (NOS II), a potent generator of nitric oxide. Therefore, it was …
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The effect of hypoxia on ER-β expression in the lung and cultured pulmonary artery endothelial cells
… ERK1/2 signaling. Interestingly, HIF-1α accumulation was noted in lung tissue of hypoxic ER-βKO mice; consistent with previously reported negative feedback of ER-β on HIF-1α protein and transcriptional activation. In RAPECs, HIF-1 stabilization and overexpression did not replicate …
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Anti-Inflammatory Effect of Sulfur Dioxide and Sulfite on Cigarette Smoke Exposed Human Airway Smooth Muscle Cells
… suggested that the hypoxia inducible factor-1α (HIF-1α) may be involved in mediating the resulting inflammation. This also suggested that the effects of cigarette smoke and sulfur dioxide, two air pollutants commonly present in the industrial areas south of Houston, might be cumulative. This …
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