Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 70 for “"HIF-1"”.
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Regulation of the hif-1-dependent hypoxic stress response by C. elegans
… oxygen is both sensed and regulated by the HIF-1 (hypoxia inducible factor) transcription factor that is activated in periods of hypoxia and goes on to regulate hundreds of genes allowing for appropriate adaptations to hypoxia. HIF-1 activation results in changes at the cellular, tissue and …
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Inhibitors of tubulin, nitric oxide synthase, and HIF-1 alpha; synthesis, biological, and biochemical evaluation.
… to these areas. The transcription factor HIF-1α has been labeled as a primary target in treating the hypoxic areas of tumors. Drugs that are effective at inhibiting HIF-1α may be better suited for treating hypoxic tumor cells. Approximately 20 compounds were analyzed for their ability to …
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The Role of Secondary and Tertiary Structure in the Cap-Independent Translation of FGF-9 and HIF-1-alpha
… IRES-like translational enhancer, and the HIF-1-alpha 5’ UTR RNA, an oncogenic CITE-like translational enhancer, take on complex, distinct secondary structures. Protein toeprinting, DAP5 SHAPE footprinting, and UV crosslinking were used to map the binding sites of DAP5 along the FGF-9 and …
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The role of HIF-1 alpha in the localization of embryonic stem cells with respect to hypoxia within teratomas
… the hypoxia-inducible transcription factor, HIF- 1[alpha], has been shown to be a tumor suppressor, and HIF-1[alpha]-expressing cells have been shown to localize preferentially in vivo to regions near tumor vasculature. These differences were proposed to be due to increased hypoxia-induced …
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Influence of Preoperative Transcatheter Arterial Chemoembolization on Gene Expression in the HIF-1α Pathway in patients with Hepatocellular Carcinoma
… in tumors, hypoxia-inducible factor 1α (HIF-1α) could critically affect biology in residual tumors after TACE treatment and subsequent prognosis. However, HIF-1α and its prognostic relevance in TACE have rarely been examined in human specimens. In the current study, we …
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BRAZILIAN PROPOLIS: A MULTIFACETED NATURAL PRODUCT WITH HEALING PROPERTIES - A COMPREHENSIVE STUDY ON THE ABILITY TO IMPROVE CUTANEOUS WOUND HEALING THROUGH HIF-1 MODULATION
… di ossigeno, i fattori indotti da ipossia (HIF) svolgono un ruolo preminente nell’espressione di numerosi geni coinvolti nel processo di guarigione. Recenti scoperte suggeriscono inoltre che la stabilizzazione farmacologica di HIF-1α, indipendentemente dalla presenza di ipossia, possa …
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Transcriptional Regulation of human Plasminogen Activator Inhibitor-1 Gene Expression by Insulin-like Growth Factor-1, Insulin and Upstream Stimulatory Factor-2
… welches den Hypoxie-induzierbaren Faktor-1 (HIF-1) binden kann, hat die IGF-1- und Insulin-abhängige PAI-1-Promotor-Aktivität fast vollständig aufgehoben. Mutationen von E4 und E5 hatten keinen Einfluss auf die IGF-1-abhängige Induktion des PAI-1-Promotor-Konstrukts unter Normoxie; unter …
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Discovery of small-molecule natural products that target cellular bioenergetics
… of solid tumors and hypoxia-inducible factor-1 (HIF-1) represents an important antitumor target. Bioenergetic homeostasis is typically altered in tumor cells and HIF-1 plays an important role to produce a glycolytic phenotype. Glycolysis inhibitors are an emerging class of potential …
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Inhibition of progestin-induced VEGF in mammary cancer by curcumin and 2-methoxy estradiol and their potential role as anti-angiogenic & chemopreventive compounds
… inhibits hypoxia inducible factor -1{alpha} (HIF-1[alpha]) and also prevents progestin-dependent VEGF release from tumor cells, suggesting that HIF-1[alpha] is an essential transcription factor for mediating the effects of progestins on VEGF elaboration. YC-1, a specific HIF-1[alpha] …
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Mechanisms of Neonatal Brain Injury in a Rat Pup Hypoxic-Ischemic Model
… treatments.</p> <p>Hypoxic inducible factor 1 (HIF-1) is a transcription factor which is stabilized and activated by hypoxia. It is the most important factor involved in the cellular response to hypoxia. However, the role of HIF-1 in the central nervous system is unclear, which has been …
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Different Effect of 5-Fluorouracil on Expression of Genes Related to Aerobic Glycolysis According to Chemoresponsiveness in Gastric Cancer Cells
… on the hypoxia-inducible factor 1α (HIF 1α). I investigated HIF1α expression and responsiveness to 5-FU in two different types of gastric cancer cells (MKN45, SNU216). In addition, we checked the change of the expressions of aerobic glycolysis related genes (GLUT1, PGK1 …
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Role of cyclin D1 as an estrogen receptor cofactor and the influence of hypoxia on estrogen receptor regulation, with focus on prognositic and treatment predictive features in breast cancer
… Hypoxia and hypoxia inducible factor-1? (HIF-1) expression has been correlated to loss of ER in breast tumors. Cyclin D1, initially described as a cell cycle regulator, might also function as a cofactor to ER inducing ligand independent activation of the receptor. We therefore determined …
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HIF, HAPE, and Hilltop rats: a paradox unfolding
… Madison rats. Hypoxia Inducible Factor-1α (HIF-1α) is exquisitely coupled to cellular hypoxia, enhancing expression of erythropoietin (EPO), vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (NOS II), a potent generator of nitric oxide. Therefore, it was …
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HYPOXIA-REGULATED EXPRESSION OF GLUT-1 IN GBM CELL LINES
… transcription factor hypoxia inducible factor 1 (HIF-1). HIF-1 is thought to directly affect glucose transporter 1 (GLUT1) expression levels in hypoxic conditions. This study sought to determine the relationship between HIF-1 and GLUT1 expression levels within normoxic and hypoxic environments …
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The multifactorial nature of hypoxia-induced drug resistance in cancer: involvement of hypoxia-inducible factor 1
… have identified hypoxia-inducible factor 1 (HIF-1), a master transcriptional regulator of oxygen homeostasis, as an important mediator of hypoxia-induced chemoresistance in cancer cells. The research described in this thesis confirms these findings and demonstrates HIF-1 is required for …
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Tumor Angiogenesis is all Tied up in Tie2-Expressing Macrophages
… under hypoxia and that macrophage knockout of, HIF-1¿¿, inhibits Tie2 receptor expression at both the protein and mRNA levels. Given this data and that hypoxia commonly occurs during the tumor development, we next investigated the effect of macrophage-specific deletion of HIF-1¿¿ in a PyMT mouse …
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AMBIENT OXYGEN AVAILABILITY MODULATES EXPRESSION OF VASCULAR ANGIOGENIC FACTORS AND CAPILLARY REMODELING (ANGIOPLASTICITY) IN THE MOUSE BRAIN
… expressions of hypoxia inducible factor-1¿¿ (HIF-1¿¿), vascular endothelial growth factor (VEGF) and erythropoietin (EPO) were increased during hypoxic exposure and diminished during subsequent re-oxygenation. However, expressions of cyclooxygenase-2 (COX-2) and angiopoietin-2 (Ang-2) were …
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Identifying a Target Protein and Ligands for Autoimmune Disorders
… an overexpression of master regulatory protein HIF-1 HIF-1is a transcription factor for pro-inflammatory cytokine interleukin-17A (IL-17A), which is highly involved in inflammatory reactions within the body. To search for a treatment for SLE, computer aided drug discovery techniques were …
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Hypoxia regulated pathways in urological malignancies
… elucidated. Hypoxia inducible factor isoforms, HIF-1 and<br/>HIF-2, are constitutively expressed in many clear-cell RCCs due to loss of pVHL tumour<br/>suppressor function within the tumour. In vitro, HIF-1 and HIF-2 regulate a differential set of<br/>target genes, although their expression in …
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