Global ETD Search
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Showing 1 to 18 of 18 for “"HIF 2α"”.
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Role of Fam60a in the Regulation of HIF-2α and Determination of Stem Cell Fate
… are sensed by the Hypoxia-Inducible Factors (HIFs). The HIFs are a family of transcription factors that are master regulators of over 100 genes and can effect changes in multiple cellular processes including migration, survival and differentiation. The broad nature of the response to hypoxia …
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Dual Mechanisms Regulating Alpha Subunit-Specific Activity in Hypoxia-Inducible Factor Signaling
… decreased oxygen availability. Two homologues, HIF-1α and HIF-2α, have been extensively studied in this field. Though they have similar domain structures and amino acid sequences, display overlap in some gene targets, and share regulatory mechanisms, they also perform distinct roles. They differ …
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Hypoxic gene regulation and oncogenic pathways in neuroblastoma
… define a role for the hypoxia inducible factor-2α in neuroblastoma tumor progression. While HIF-1α was transiently stabilized at hypoxia (1% oxygen), HIF-2α was induced and regulated HIF-specific target genes, such as VEGF, at later time points. Furthermore, HIF-2α was stabilized and …
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Generation and Transcriptomic Analysis of HIF-1Alpha and HIF-2Alpha Knockout 5TGM1 Multiple Myeloma Cells
… are mediated through Hypoxia-Inducible Factor (HIF) signalling. The HIFs are heterodimeric transcription factors that activate the transcription of hundreds of target genes in response to hypoxia. In most solid tumours, HIF signalling is co-opted to contribute to tumour survival and progression. …
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HIF and NF-ĸB Crosstalk: The Role of HIF-1β as an Inducer of the Inflammatory Response
… factors NF-kB and Hypoxia Inducible Factors (HIFs), respectively. However, over the past years, the inflammatory response has been associated with hypoxia both in immune cells and in cancer cells. The crosstalk between NF-kB and HIF is extensive, including shared activating stimuli and …
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Translational Aspects of Erythropoietin Receptor and Hypoxia-Inducible Factors in Breast Cancer
… response are the hypoxia-inducible factors (HIFs) 1 & 2. We have investigated HIF-1α and HIF-2α expression in breast cancer and found a correlation between HIF-2α expression and distant metastasis and impaired prognosis, suggesting that HIF-2α has an important role in tumor progression. We …
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Organ-specific heterogeneity in the endothelial cell hypoxia response
… the two hypoxia inducible transcription factors HIF-1α and HIF-2α in the murine lung endothelium during cancer metastasis, and how the hypoxia response of the vascular endothelium remodels the lung pre-metastatic niche. Previous work had shown that lung endothelial-specific knockouts of HIF-1α …
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Hypoxia and Hypoxia-Inducible Factors in Normal and Malignant Breast Epithelium
… that hypoxia and hypoxia-inducible factors (HIF:s) contribute to tumor progression. We therefore set out to explore the impact of hypoxia on mammary epithelial differentiation and what consequences the hypoxic response might have on breast cancer development and behavior. We found that …
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Cellular Coping Mechanisms to Hypoxia in the Longhorn Sculpin (Myoxocephalus octodecemspinosus) Brain
… expression levels of hypoxia-response elements HIF-2α and Hsp70 were examined at the transcriptome level at each time point using RT-QPCR, and HIF-1α, active caspase 3, and survivin, were explored at the protein level using immunohistochemistry and fluorescence microscopy. HIF-2α mRNA levels …
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Identification of Novel HIF1A Target Genes That Regulate Tumor Progression and Metastasis
… The heterodimeric HypoxiaInducible Factor (HIF) transcription factors are the master regulators of this response. HIFs play key roles in many critical aspects of cancer biology including angiogenesis, stem cell maintenance, metabolic reprogramming, invasion, metastasis and resistance to …
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MEIS1: At the Crossroads Between Metabolic and Cell Cycle Regulation
… Furthermore, we demonstrate that Meis1 and Hif-1α are markedly enriched in HSCs and that Meis1 functions upstream of the two master redox regulators Hif-1α and Hif-2α, where loss of Meis1 results in a metabolic shift from glycolysis to mitochondrial oxidative metabolism, and increased …
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The effect of hypoxia on macrophage proteoglycans: potential role in atherosclerosis
… the hypoxia-inducible transcription factors HIF-1α and HIF-2α, and that HIF-1α and versican co-localized in macrophage-rich areas in human advanced atherosclerotic lesions. The negative charge of PG is on their attached glycosaminoglycans (GAG). We found that GAG secreted under hypoxic …
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Mechanisms of Synthetic Lethality in Renal Cell Carcinoma
… for targeting Hypoxia Inducible Factors (HIFs) for proteasomal degradation. Accumulation of the HIF-2α isoform, in particular, drives renal tumourigenesis. *VHL* loss occurs at an early stage of ccRCC development, often several years before the clinical manifestation of disease, and so is …
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Hypoxia signalling regulates human lung epithelial cell fates
… hillock-like cells. Hypoxia-inducible factors (HIFs) are the central regulators mediating cellular response to hypoxia. I found that the HIF pathway was rapidly activated upon exposure to hypoxia with a genetic HIF-DNA binding reporter. Chemical stabilisation of HIF-α subunits (HIF-1α and …
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Studies on renal progenitor cells and kidney cancer
… is affected by hypoxia inducible factor 2 alpha (HIF-2α), an important protein in the cellular oxygen sensing system, which is ubiquitously expressed in the constantly pseudohypoxic ccRCC tumors. We further demonstrate that hypoxia induces SLC6A3 expression in normal kidney cells, but not in cells …
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Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Carcinoma
… hypoxia, tumor cells induce a transcriptional shift which is mainly regulated by the transcription factors hypoxia-inducible factor (HIF)-1 and HIF-2. HIF proteins consist of two subunits, an oxygen-regulated α-subunit and a constitutively expressed β-subunit. Previous reports have shown that …
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Inhibition of Breast Cancer Angiogenesis and Metastasis ay Targeting Hypoxia-Inducible Factor-1α
… response to proliferation. In animal models, HIF-1 (a heterodimer composed of one of the three alpha subunits-HIF-1α, HIF-2α or HIF-3α- and one constitutively expressed HIF-1β subunit) overexpression is associated with increased tumor growth, vascularization, and metastasis. The goal of this …
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Investigating the role of the UDP-galactose transporter SLC35A2 in the regulation of HIF signalling
Background: <br>The hypoxia inducible factor (HIF) family of dimeric transcription factors play a vital role in the cellular response to low oxygen (hypoxia). HIF activation leads to the transcriptional upregulation of a range of genes that are involved in diverse physiological and …