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Showing 1 to 20 of 200 for “"HIF"”.

  1. The Mammalian Hypoxia Response Pathway: Regulation of HIF and HIF Prolyl Hydroxylases

    Ozer, Abdullah2007

    … factor called Hypoxia Inducible Factor (HIF). HIF is composed of an oxygen-sensitive alpha -, and an oxygen-insensitive beta -subunit (ARNT). The stability and transcriptional activity of HIF alpha are controlled by two different Fe(II)- and 2- oxoglutarate-dependent dioxygenases that …

    tdl Repository record

  2. Generation and Transcriptomic Analysis of HIF-1Alpha and HIF-2Alpha Knockout 5TGM1 Multiple Myeloma Cells

    Chey, Yu Chinn Joshua2019

    … are mediated through Hypoxia-Inducible Factor (HIF) signalling. The HIFs are heterodimeric transcription factors that activate the transcription of hundreds of target genes in response to hypoxia. In most solid tumours, HIF signalling is co-opted to contribute to tumour survival and progression. …

    adelaide Repository record

  3. HIF and NF-ĸB Crosstalk: The Role of HIF-1β as an Inducer of the Inflammatory Response

    D'Ignazio, LauraUniversity of Dundee2018

    … factors NF-kB and Hypoxia Inducible Factors (HIFs), respectively. However, over the past years, the inflammatory response has been associated with hypoxia both in immune cells and in cancer cells. The crosstalk between NF-kB and HIF is extensive, including shared activating stimuli and …

    dundee Repository record

  4. HIF, HAPE, and Hilltop rats: a paradox unfolding

    Engebretsen, Barbara J., author, Tucker, Alan, advisor, Miller, C. W., committee member, Gotshall, Robert, committee member, Cordain, Loren, committee memberColorado State University. Libraries2003

    … Madison rats. Hypoxia Inducible Factor-1α (HIF-1α) is exquisitely coupled to cellular hypoxia, enhancing expression of erythropoietin (EPO), vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (NOS II), a potent generator of nitric oxide. Therefore, it was …

    colostate Repository record

  5. Role of PBRM1 in regulation of the HIF pathway

    Shmakova, AlenaUniversity of Dundee2016

    … and an oxygen-independent β subunit. In normoxia HIFα is quickly degraded by a VHL-mediated mechanism whereas hypoxia stabilizes this subunit making it available to form an active complex and induce transcription of its target genes. Recently, it was shown that the SWI/SNF chromatin remodeling …

    dundee Repository record

  6. HIF-1alpha role in oxygen-dependent radio- and chemosensitivity

    Gebolys, KingaUniversity College Cork2014

    … stabilisation of hypoxia-inducible factor-1α (HIF-1α) leads to changes in expression of various genes associated with growth, vascularisation and metabolism. However whether HIF-1α plays a causal role in promoting hypoxic resistance to antitumour therapies remains unclear. In this study we used …

    cork Repository record

  7. Epigenetic Regulation Of The HIF Pathway And Novel Therapeutic Opportunities

    Ponnaluri, Venkata Krishna ChaithanyaUniversity of Missouri--Kansas City2014

    … understanding the epigenetic regulation of the HIF pathway and the efficacy of treatment for retinal diseases and hemangioblastomas using HIF pathway inhibitors. Jumonji domain containing proteins demethylate tri- and dimethylated histone lysines and regulate chromatin structure. Substrate …

    umkc Repository record

  8. DNMT3a Epigenetic Program Regulates the HIF-2alpha Oxygen Sensing Machinery

    Lachance, GabrielUniversité d'Ottawa / University of Ottawa2015

    … in the regulation of hypoxia-inducible factor (HIF) oxygen-sensing machinery. We show that DNA methyltransferase 3a (DNMT3a) methylates and silences the HIF-2alpha gene (EPAS1) in normal cells. Epigenetic silencing of EPAS1 prevents activation of the HIF-2alpha gene program associated with …

    ottawa-retro Repository record

  9. 유두상갑상선미세암에서혈관내피성장인자(VEGF),혈관내피성장인자수용체-1(VEGFR-1),저산소증유발인자(HIF-1a)의mRNA발현

    윤, 태일2011

    … 발현을 유도하는 저산소증 유발인자(Hypoxic induced factor 1α, HIF-1α), 각각의mRNA발현정도를 분석하여 신생혈관생성의 발현형의 변화여부를 확인하고 여러 임상 및 병리적 특징과 VEGF mRNA의 발현정도와의 상관관계를 분석 하기 위하여 시행되었다. 대상 및 방법: 유두상 갑성선암 진단 하에 갑상선절제술을 시행한 환자 중 종양의 크기가 10mm이하인14명의 환자를 대상으로 수술 중에 암종양조직과 동측의 정상갑상선조직을 채취하여 mRNA의 손상을 막기 위해 조직을 RNA later용액을 첨가하여 …

    ajou Repository record

  10. Development of Hif-1Α/Hif-1Β Heterodimerization Inhibitors Using A Novel Bioluminescence Reporter Assay System For In Vitro High Throughput Screening and In Vivo Imaging

    Chiang, Yun-Chen2014

    … heterodimerization of hypoxia-inducible factor (HIF)-1α and HIF-1β, which subsequently upregulates the expression of several hypoxia-inducible genes, promotes cell survival and stimulates angiogenesis in the oxygen-deprived environment. Hypoxic tumor regions are often associated with resistance …

    uthsc Repository record

  11. HIF-2: Standing Guard at the Crossroads of Stress and Aging

    Dioum, El Hadji Mamadou2010

    … α (alpha) subunit of Hypoxia inducible factors (HIF-1alpha and HIF-2 alpha). HIF-1 alpha and HIF-2 alpha have similar structural organization, and after forming an obligate heterodimer with the common partner ARNT/HIF-1 alpha, bind to the same recognition element located in target gene promoter …

    utswmed Repository record

  12. Evaluation Of HIF Inhibitors For The Treatment of Ocular Neovascular Diseases

    Vavilala, Divya TejaUniversity of Missouri--Kansas City2015

    Hypoxia-inducible-factor (HIF)-mediated expression of pro-angiogenic genes under hypoxia is the fundamental cause of pathological neovascularization in ocular diseases and cancers. Thus, the inhibitors of the HIF pathway or key regulators such as histone demethylases (KDMs), that amplify HIF …

    umkc Repository record

  13. Role of the NF-kappaB-HIF Crosstalk in Inflammation and Hypoxia

    Bandarra, DanielUniversity of Dundee2014

    … factor called Hypoxia Inducible Factor (HIF). HIF has recently been associated with a role in inflammation and immunity. Importantly, HIF-1alpha has shown to be regulated by the major inflammatory responsive transcription factor, NF-kappaB (nuclear factor kappaB). Here it is demonstrated …

    dundee Repository record

  14. A HIF-INDEPENDENT PROGRAM SUSTAINS TUMOR TREG FUNCTION IN OXYGEN-DEPRIVED ENVIRONMENTS

    ARRIGONI, JACOPOUniversità degli Studi di Milano2025

    … of Treg showed reduced hypoxia-inducible factor (HIF) signaling in TI- Treg, so we explored alternative responses. We performed time-course RNA-seq of Treg in either oxygen condition and analyzed transcription factor motifs in differential cis-regulatory elements, finding oxygen sensor RBPJ to be …

    milano Repository record

  15. Regulation of HIF-1α during Hypoxia by DAP5-Induced Translation of PHD2

    Bryant, Jeffrey2018

    … surge of hypoxia-inducible factor 1α (HIF-1α), the transcription factor and master switch of the hypoxia response. The hypoxia response is tempered through HIF-1α hydroxylation by the oxygen-sensing prolyl hydroxylase-domain protein 2 (PHD2), and subsequent ubiquitination and …

    duke Repository record

  16. Regulation of the hif-1-dependent hypoxic stress response by C. elegans

    Diehl, Calista SorineMassachusetts Institute of Technology2024

    … oxygen is both sensed and regulated by the HIF-1 (hypoxia inducible factor) transcription factor that is activated in periods of hypoxia and goes on to regulate hundreds of genes allowing for appropriate adaptations to hypoxia. HIF-1 activation results in changes at the cellular, tissue and …

    mit Repository record

  17. LSD1 metabolically integrates osteoclast differentiation and inflammatory bone resorption through HIF-1α and E2F1

    Doi, KoheiKyoto University2022

    kyoto Repository record

  18. Role of Fam60a in the Regulation of HIF-2α and Determination of Stem Cell Fate

    Biddlestone, JohnUniversity of Dundee2014

    … are sensed by the Hypoxia-Inducible Factors (HIFs). The HIFs are a family of transcription factors that are master regulators of over 100 genes and can effect changes in multiple cellular processes including migration, survival and differentiation. The broad nature of the response to hypoxia …

    dundee Repository record

  19. Inhibitors of tubulin, nitric oxide synthase, and HIF-1 alpha; synthesis, biological, and biochemical evaluation.

    Hall, John Jacobs.Baylor University.2008

    … to these areas. The transcription factor HIF-1α has been labeled as a primary target in treating the hypoxic areas of tumors. Drugs that are effective at inhibiting HIF-1α may be better suited for treating hypoxic tumor cells. Approximately 20 compounds were analyzed for their ability to …

    baylor Repository record

  20. Investigating the role of the UDP-galactose transporter SLC35A2 in the regulation of HIF signalling

    Greef, BasmaUniversity of Cambridge2023

    Background: <br>The hypoxia inducible factor (HIF) family of dimeric transcription factors play a vital role in the cellular response to low oxygen (hypoxia). HIF activation leads to the transcriptional upregulation of a range of genes that are involved in diverse physiological and …

    cambridge Repository record

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