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Showing 1 to 18 of 18 for “"HGSOC"”.
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Investigating lipid metabolism and gene expression in High Grade Serous Ovarian Cancer (HGSOC) disease progression and chemoresistance
HGSOC is the most common and deadly form of ovarian cancer and is characterised by vague symptoms, late diagnosis and a high level of metastasis. While most patients initially respond well to the current standard of treatment – tumour debulking surgery and platinum/taxane combination chemotherapy – …
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The Role of Ifitm3 In The Immune Response of Brca-Deficient High Grade Serous Ovarian Carcinoma
… high grade serous ovarian carcinoma (HGSOC) had increased tumor infiltrating lymphocytes (TILs) compared to BRCA-wildtype (WT). To better understand the underlying immune mechanism in these tumors, a preliminary transcriptome analysis was performed on a set of microdissected HGSOC …
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Biomarkers of Genome Instability and Disease Progression in Ovarian Cancer
High grade serous ovarian carcinoma (HGSOC) is the most common subtype of ovarian cancer and the major cause of gynaecological cancer-related deaths in the Western world. Overall survival for HGSOC patients has not improved over the last two decades, and the progressive evolution of chemotherapy …
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Altered Ovarian Cancer Metabolism Increases Neuronal N-Acetylaspartate to Promote Tumor Growth
… high grade serous epithelial ovarian cancers (HGSOC) are unknown.</p> <p>Materials and Methods: Following IRB approval, metabolic profiling of 101 HGSOC patients and 15 normal ovaries were obtained using GC/LC mass spectrometry from 2 U.S. academic centers to identify highly up-regulated …
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Genomic aberrations as determinants of immune infiltrates in high grade serous ovarian carcinoma
… abundance in high grade serous ovarian cancer (HGSOC), mutational processes by which tumours gain immunogenicity or develop immune evasion are yet to be identified. Mutational processes that play a key role in HGSOC tumourigenesis leave imprints of copy-number aberrations (CNA) in the patient’s …
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Advancing Ovarian Cancer Diagnostics: Discovering Potential Protein Biomarkers in Extracellular Vesicles
High grade serous ovarian carcinoma (HGSOC) accounts for ~70% of ovarian cancer cases. Non-invasive, highly specific blood-based tests for pre-symptomatic screening in women are crucial to reducing the mortality associated with this disease. The goal of these studies was to uncover novel biomarkers …
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Improving earlier non-invasive diagnosis of high-grade serous ovarian cancer
… biomarker for high grade serous ovarian cancer (HGSOC), was to investigate low-cost high-throughput next generation sequencing assays in plasma samples collected from women with newly diagnosed OC. The secondary aim was to apply these methods to other non-invasive samples including cervical …
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ELUCIDATING THE IMPACT OF ASCITES ON HIGH GRADE SEROUS OVARIAN CANCER THROUGH MULTIPLE IN VITRO PATIENT-SPECIFIC MODELS
High-grade serous ovarian cancer (HGSOC) is a highly heterogeneous and aggressive malignancy characterized by marked inter-/intra-tumor variability and a dynamic tumor microenvironment (TME). The TME, and particularly ascitic fluid (AF), plays a critical role in OC progression by influencing tumor …
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Layer-by-Layer Nanoparticles for Targeted Delivery and Treatment of Ovarian Cancer
… late stage high grade serous ovarian cancer (HGSOC), which is highly metastatic. While many patients initially respond to treatment with debulking surgery and adjuvant chemotherapy, most will have residual disease and relapse. Depending on the extent of metastatic spread and the size of nodal …
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Influencing Pathways that Cause Metastasis and Stemness in Epithelial Ovarian Cancer
… of cases High Grade Serous Ovarian Carcinoma (HGSOC) is the most common type of ovarian cancer and causes 90% of ovarian cancer deaths. 80% of patients have reoccurrence within five years and only 15-30% of patients with recurrent metastatic ovarian cancer respond to current therapies, …
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Unravelling the Spatial and Temporal Heterogeneity of High-Grade Serous Ovarian Cancer Using Imaging-Based Biomarkers
High-Grade Serous Ovarian Cancer (HGSOC) is the most prevalent and lethal subtype of ovarian cancer, characterised by significant spatial and temporal heterogeneity, which has been linked to poor survival outcomes. In this challenging landscape, the quest to characterise heterogeneity through …
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Imaging Metabolic Signatures in High Grade Serous Ovarian Cancer
<p>High Grade Serous Ovarian Cancer (HGSOC) can be classified by gene copy number signatures into 7 subtypes that have differing prognoses and treatment sensitivities and that show differences in the activities of various signalling pathways. An ongoing clinical study has demonstrated the …
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Investigating the Role of RNA-Binding Proteins in Tumor Response to DNA Damage-Inducing Chemotherapy
… in high-grade serous ovarian carcinoma (HGSOC) we performed a targeted CRISPRi screen in vitro against 579 RBPs to identify those that cause sensitivity or resistance to cisplatin, oxaliplatin, paclitaxel, or olaparib. The screen implicated several known and novel RBPs in affecting …
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Phenotypic heterogeneity in high-grade serous ovarian cancer: evidence for a stochastic model of proliferation
High-grade serous ovarian cancer (HGSOC) represents the largest and most lethal subtype of ovarian cancers. Chemotherapy is effective at depleting these tumours, sometimes eliminating all visible disease, however the tumour invariably regrows from surviving tumour cells. Improving treatment depends …
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Tumour evolution in ovarian cancer using high-throughput genomics technologies
High-grade serous ovarian carcinoma (HGSOC) is characterised by genomic instability, ubiquitous TP53 loss, widespread disease at diagnosis and the frequent emergence of platinum resistance. This thesis explores the use of high-throughput genomics technologies to understand if resistance could be …
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UNCOVERING IMMUNE EVASION MECHANISMS FOR THE PROGNOSIS AND THERAPY OF ENDOMETRIAL AND OVARIAN CANCERS
… of stage I high-grade serous ovarian cancer (HGSOC) tumor microenvironment (TME), the most common subtype of OC, to assess the impact of the TME in OC progression and to identify potential immunotherapeutic targets. Within the HGSOC lesions we detected high enrichment of CD4 regulatory T cells …
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Analysing the relationship between immune infiltration and tissue architecture in high grade serous ovarian cancer
… them in high grade serous ovarian cancer (HGSOC). The quantitative distribution of three key immune infiltrates was initially assessed in the SEARCH cohort (n=332); CD8+ cytotoxic T-cells, CD45RO+ memory T-cells and CD68+ macrophages. The stromal infiltration of CD68+ (HR = 0.44, p = 3×10−4 …
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Development and evaluation of methodologies for analysis of CTC and ctDNA in patients with ovarian carcinoma
… patients with high grade serous ovarian cancer (HGSOC) enrolled in a neoadjuvant chemotherapy (NACT) plus immune checkpoint inhibitor clinical trial (iPRIME, ACTRN12618000109202) (Chapter 5). Cell free DNA (cfDNA) was sequenced using the Oncomine™ Breast cfDNA Research Assay V2, and selected …