Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"HGPS"”.
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The Convergence of Accelerated and Physiological Vascular Ageing: A Multi-Omic Analysis of 2D and 3D in vitro models of Progeria
… disease, Hutchinson Gilford Progeria Syndrome (HGPS), provide an indefinite source of human cells which recapitulate several hallmarks of ageing. Furthermore, the cardiovascular pathology of HGPS closely resembles that of elderly individuals, with patients showing severe vascular stiffening and …
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The Application of a Statistical Model Investigating Reactive Oxygen Species in Premature Ageing Syndromes
… syndromes Hutchison-Gilford Progeria Syndrome (HGPS) and Restrictive Dermopathy (RD) are rare genetic disorders that result in greatly accelerated ageing. RD is neonatal fatal, whereas children suffering from HGPS age approximately 8 times faster than normal individuals and die during their …
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1, Structural and Functional Studies of Human Replication Protein A; 2 DNA Damage Responses and DNA Repair Defects in Laminopathy-Based Premature Aging.
… aging. In Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD), premature aging is caused by defective maturation of lamin A and linked to accumulation of DNA double-strand breaks (DSBs). However, how lamin A dysfunction leads to genome instability and premature aging is …
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Characterization of the Dunkin Hartley guinea pig as a non-transgenic and multimorbid model of brain aging
… Hartley guinea pig (HGP) may address this need. HGPs are known to develop systemic inflammation and progressive age-related comorbidities characteristic of human aging. The presence of this whole-body aging phenotype prompted investigation into the brain. Genetic and transcriptomic analyses found …
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Neuronal regulation of haematopoietic stem cell ageing and age-related blood disorders through the microenvironment
… in Hutchinson-Gilford progeria syndrome (HGPS). Chronic treatment of β3-AR agonist partially rejuvenates premature haematopoietic ageing in HGPS and restores exacerbated megakaryopoiesis in myeloproliferative neoplasms (MPNs). In summary, these results suggest that HSC niche remodelling …
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Mechano-sensitivity of nuclear lamin proteins in endothelial cells
… between Hutchinson Gilford Progeria Syndrome (HGPS) cells and aging cells, implicating dysfunctions of lamin A/C in aging process and atherosclerosis, as HGPS is caused by a mutated form of lamin A/C. Blood flow in arteries is generating shear stress that is mostly applied on endothelial cells …
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Novel functions of N-acetyltransferase 10 (NAT10) in DNA repair and replication with potential implications for premature ageing syndromes
Hutchinson-Gilford Progeria Syndrome (HGPS) is an invariably fatal disease with a range of diverse symptoms that are normally associated with those of advanced age. In recent decades, clinicians and scientists together have made great progress in deriving the mechanisms of disease initiation and …
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New biological mechanisms and intervention strategies in aging and cancer
… causante del síndrome de Hutchinson-Gilford (HGPS). Estos ratones recapitulan fielmente las alteraciones genéticas y fenotípicas presentes en este síndrome, lo cual nos ha permitido desarrollar una estrategia terapeútica basada en la administración de oligonucleótidos antisentido y dirigida a …
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Analysis of the immune function and its relevance in mouse models of premature aging
… del Síndrome de Progeria de Hutchinson-Gilford (HGPS), LmnaG609G/G609G y Zmpste24-/-, con el objetivo de identificar nuevos factores que promueven el envejecimiento prematuro y su similitud con el envejecimiento fisiológico. Para este fin, realizamos un análisis global del proteoma del plasma en …
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Functional gene analysis in cultured vertebrate cells using siRNA mediated gene silencing
… mit dem Hutchinson Gilford Progeria Syndrom (HGPS) in Verbindung steht, das humane Protein Astrin, sowie Proteine der Kinetochore (scc1, smc1, smc3, securin und separase) und Kinesin verwandte Motorproteine (MCAK, TPX2, HSET, KIA0622).Die Zinkfinger Metallprotease prozessiert das …
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Estimativa da resolução de modelos geoidais globais obtidos de missões satelitais e gravimétricos regionais para o estado do Paraná com base em observações GPS sobre RNs
… GPS/Niv, utilizando-se as diferenças NGPS = hGPS -HRN. O primeiro modelo geoidal local considerado foi criado por GOLDANI (2006) com o emprego da técnica Remove-Restore, usando a decomposição das diferentes contribuições espectrais da altura geoidal, com a Transformada Rápida Fourier (FFT). …
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Studies of TeV Gamma-Ray Sources in the Hydrogen-Alpha Optical Line
… as well as the HESS galactic plane survey (HGPS), looking for attributes that may link the two emission channels. Moreover, other radio and X-ray surveys are used with some HESS candidates to provide more evidence in different electromagnetic wavelengths. A model is used to calculate the SNR …
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Single-Objective Tilted Light Sheet Illumination with Exchange-PAINT and Deep Learning for Fast, Accurate, and Precise 3D Single-Molecule Super-Resolution Imaging in Mammalian Cells
… in Hutchinson-Gilford Progeria Syndrome (HGPS), a disorder caused by a mutation in the LMNA gene.