Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 71 for “"HGF"”.
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Activation of HGF/Met Signaling Induces Delayed STAT3 Phosphorylation
… by its ligand, hepatocyte growth factor (HGF, also known as scatter factor). Activation of HGF-Met signaling is known to play potentially important roles in tumorigenesis. STATs mediate many of the cellular responses that occur following cytokine, growth factor, and hormone stimulation. …
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Expression of E-cadherin and HGF in Hypopharyngeal Cancer
… cohesion and hepatocyte growth factor(HGF), a potent stimulator of hepatocyte growth, stimulates motility, invasiveness, proliferation, and morphogenesis of epithelium, and also may be involved in tumor invasion. So we examined the role of the E-cadherin/HGF on invasion and metastasis …
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caffeine에 의한 HGF-induced G2 delay 촉진효과 확인 및 기전분석
… the role of caffeine in G2 delay induced by HGF. Previously, we have shown that HGF induced transient G2 delay via ERK pathway. To address the involvement of ATM/ATR kinases in HGF-induced G2 delay, caffeine was used as an inhibitor. Interestingly, caffeine couldn't inhibit the HGF-induced G2 …
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The role of PAK6 in HGF-induced prostate cancer cell migration
… migratory morphology. Hepatocyte growth factor (HGF) signalling is known to induce cell-cell dissociation and is associated with prostate carcinoma progression. HGF-induced cell-cell dissociation and migration require the activity of the Rho family GTPases Rho A, Racl and Cdc42 and their effector …
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Regulation of Hgf Expression By Δegfr-Mediated C-Met Activation In Glioblastoma Cells
… and its ligand, the hepatocyte growth factor (HGF), and a constitutively active mutant of the epidermal growth factor receptor (∆EGFR/EGFRvIII), occur frequently in glioblastoma. c-Met is activated in a ligand-dependent manner by HGF or in a ligand-independent manner by ∆EGFR. Dysregulated …
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Synthesis of small-molecule HGF-Met inhibitors for use in preventing cell motility
… motility through competitive inhibition of the HGF-Met pathway. This pathway is extremely important in various cellular processes including cancer development, metastasis, tissue regeneration, damage and cell motility. This project aimed to synthesise a series of easily prepared (3 step) mono, …
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HGF als anti-fibrotisches Agens: Effekte der Überexpression in renalen Fibroblasten und Tubulusepithelzellen
… dem potentesten profibrogen wirkenden Zytokin. HGF ist ein endogenes Zytokin, mit renoprotektiven Fähigkeiten. Es besitzt als Antagonist von TGF-β1 ein hohes antifibrotisches Potential.In der vorliegenden Arbeit wurden die Effekte einer HGF-Überexpression an murinen Tubulusepithelzellen (NP1) …
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Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma
Understanding the function of the HGF-Met signalling axis could present opportunities for new therapeutic treatments for cancer patients. The brain tumour Medulloblastoma is the leading cause of cancer-related death in children and infants meaning research into better treatment of this cancer is …
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Activation of Ca<sup>2+</sup>-activated K<sup>+</sup> Channels and Cell Migration by Hepatocyte Growth Factor/Scatter Factor in Madin-Darby Canine Kidney Cells.
<p>Hepatocyte Growth Factor/Scatter Factor (HGF/SF) stimulates migration of various cells and has been linked via Met tyrosine kinase signaling to transformation and the metastatic phenotype. HGF/SF-Met signaling also plays a role in malignancy. Migration of transformed MDCK-F cells depends on …
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hepatocyte growth factor inhibits glial scar formation and
… spinal cord injury. Hepatocyte growth factor (HGF), which was originally identified as a mitogen for hepatocytes, has been shown to strongly suppress fibrosis of internal organs such as liver and kidney. However, its role in the regulation of CNS glial scars has not been studied. The purpose of …
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Immunomodulation in Adenovirus-Induced Viral Hepatitis
… 33 (IL-33) and hepatocytes growth factor (HGF) have great potential for developing therapeutic strategies. The liver produces and releases IL-33 and HGF upon viral infection, two molecules that favor hepatocyte survival by up-regulating bcl-2 gene, which have also immune regulatory …
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Green Tea Polyphenol Epigallocatechin-3-gallate Inhibits Hepatocyte Growth Factor-Induced Tumor Cell Migration and Invasion In Vitro and In Vivo
" 간세포성장인자(hepatocyte growth factor,HGF)와 그 수용체인 Met의 과 활성화는 많은 종류의 종양의 발생과 진행에 관여하는 것으로 알려져 있다. 본 연구에서는 HGF/Met 신호전달체계를 효과적으로 억제하는 물질을 찾아보고자하였고 녹차의 성분 중 생체에 영향을 주는 중요한 polyphenol인 Epigallocathechin-3-gallate(EGCG)가 HGF/Met 신호체계를 효과적으로 억제할 수 있다는 것을 발견하였다. EGCG는 HGF에 의한 Met의 활성 방식이 autocrine이든 …
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Up-modulation of Hepatocyte Growth Factor/ c-Met Signaling by Protein Kinase C-g and its Mechanism
… the receptor for hepaotcyte growth factor (HGF). However, specified roles by PKC isoenzymes on the regulation of HGF/c-Met signaling have never been addressed yet. In this study, attempts have been made to investigate the effect of PKC-γ, an isoenzyme of PKC, on the HGF/c-Met signaling and …
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Interaction of Human umbilical vein endothelial cells and human hepatocytes celline on Gelatin-VEGF Microspheres and PHBV-HGF Microspheres in co-culture
This research focused on the fabrication of HGF encapsulated PHBV microspheres and VEGF encapsulated gelatin microspheres to ensure controlled release of growth factors as the microspheres degrade during cell culture. Blank microspheres and 2D cell cultures were used as controls. Characterization …
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The Role and Mechanism of Enhanced Met Expression in Pancreatic Cancer
… their mechanisms of action be understood. The HGF/Met signaling axis has been implicated in pancreatic cancer due to increased protein expression of HGF and Met. In this dissertation, I tested the hypothesis that Met signaling promotes pancreatic tumor growth using shRNA mediated knock down of …
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Molecular Insights and Physiological Consequences of Aryl Hydrocarbon Receptor Regulated Plasminogen Activator Inhibitor-1 Expression
… and activation of hepatocyte growth factor (HGF) from its latent form in the extracellular matrix. Once activated, HGF signalling through its receptor cMet is a crucial component early in regeneration. Recent studies identified a sequence distinct from the canonical AhR binding site, the …
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A Novel Function For 12-Lipoxygenase In C-Met And Integrin β4 Axis Crosstalk
… in a cell type and condition specific manner. HGF treatment led to beta4 phosphorylation, disruption of the c-Met interaction, and concomitant 12-LOX recruitment. However, despite 12-LOX recruitment, LC-MS analyses showed that HGF stimulation did not lead to increased 12(S)-HETE production. …
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